Significant CSF Brain Protein Changes in first-attack CIS-MS vs. established RR-MS and Controls Increased in first attack CIS-MS vs. established RR-MS, Controls.

<p>Significant CSF Brain Protein Changes in first-attack CIS-MS vs. established RR-MS and Controls Increased in first attack CIS-MS vs. established RR-MS, Controls.</p

Increased in first-attack CIS-MS vs established RR-MS, but Decreased in first-attack CIS-MS vs Controls.

<p>Increased in first-attack CIS-MS vs established RR-MS, but Decreased in first-attack CIS-MS vs Controls.</p

In-depth off-line 2D-LC-<i>MS/MS</i> analysis of the CSF proteome of a pooled sample composed of CSF from all MS patients resulted in the identification of 2820 proteins, and the comparison to previous results obtained from analyses of healthy normals [8] and other neurologic disease (OND) [9].

<p>In-depth off-line 2D-LC-<i>MS/MS</i> analysis of the CSF proteome of a pooled sample composed of CSF from all MS patients resulted in the identification of 2820 proteins, and the comparison to previous results obtained from analyses of healthy normals <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066117#pone.0066117-Schutzer1" target="_blank">[8]</a> and other neurologic disease (OND) <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066117#pone.0066117-Schutzer2" target="_blank">[9]</a>.</p

Decreased in first-attack CIS-MS vs established RR-MS and controls.

<p>Decreased in first-attack CIS-MS vs established RR-MS and controls.</p