1,897 research outputs found
A response to high-dose estrogen for tamoxifen, aromatase inhibitor and trastuzumab refractory HER2+ and ER+ advanced breast cancer
A low-power, radiation-hard gigabit serializer for use in the CMS electromagnetic calorimeter
An integrated fiber-optic bit serializer and VCSEL driver has been constructed in radiation-hard complementary heterostructure GaAs FET (CHFET) technology. The serializer, which converts 20 parallel inputs into a high-speed serial output, consumes 60 mW at nominal supply voltage when operating at the Large Hadron Collider word rate of 40 MHz (0.8-GB/s serial rate). The integrated driver directly drives a VCSEL and provides 10-mA switched current and 5 mA of prebias. The complete digital optical link thus consumes 90 mW. (6 refs)
Light-to-light readout system of the CMS electromagnetic calorimeter
For the Compact Muon Solenoid (CMS) experiment at the Large Hadron Collider (LHC) at CERN, an 80,000-crystal electromagnetic calorimeter will measure electron and photon energies with high precision over a dynamic range of roughly 16 bits. The readout electronics will be located directly behind the crystals, and must survive a total dose of up to 2Ă—104 Gy along with 5Ă—1013 n/cm 2. A readout chain consisting of a custom wide-range acquisition circuit, commercial ADC and custom optical link for each crystal is presently under construction. An overview of the design is presented, with emphasis on the large-scale fiber communication syste
Cross-linguistic study of vocal pathology: perceptual features of spasmodic dysphonia in French-speaking subjects
Clinical characterisation of Spasmodic Dysphonia of the adductor type (SD) in French speakers by Klap and colleagues (1993) appears to differ from that of SD in English. This perceptual analysis aims to describe the phonetic features of French SD. A video of 6 French speakers with SD supplied by Klap and colleagues was analysed for frequency of phonatory breaks, pitch breaks, harshness, creak, breathiness and falsetto voice, rate of production, and quantity of speech output. In contrast to English SD, the French speaking SD patients demonstrated no evidence pitch breaks, but phonatory breaks, harshness and breathiness were prominent features. This verifies the French authors’ (1993) clinical description. These findings suggest that phonetic properties of a specific language may affect the manifestation of pathology in neurogenic voice disorders
The 3D Kinematics of Gas in the Small Magellanic Cloud
We investigate the kinematics of neutral gas in the Small Magellanic Cloud
(SMC) and test the hypothesis that it is rotating in a disk. To trace the 3D
motions of the neutral gas distribution, we identify a sample of young, massive
stars embedded within it. These are stars with radial velocity measurements
from spectroscopic surveys and proper motion measurements from Gaia, whose
radial velocities match with dominant HI components. We compare the observed
radial and tangential velocities of these stars with predictions from the
state-of-the-art rotating disk model based on high-resolution 21 cm
observations of the SMC from the Australian Square Kilometer Array Pathfinder
telescope. We find that the observed kinematics of gas-tracing stars are
inconsistent with disk rotation. We conclude that the kinematics of gas in the
SMC are more complex than can be inferred from the integrated radial velocity
field. As a result of violent tidal interactions with the LMC, non-rotational
motions are prevalent throughout the SMC, and it is likely composed of distinct
sub-structures overlapping along the line of sight.Comment: 9 pages, 5 figures, 1 Appendix; ApJ accepte
Total dose effects on deep-submicron SOI technology for Monolithic Pixel Sensor development
We developed and characterized Monolithic pixel detectors in deep-submicron Fully Depleted (FD) Silicon On Insulator (SOI) technology. This paper presents the first studies of total dose effects from ionizing radiation performed on single transistor test structures. This work shows how the substrate bias condition during irradiation heavily affects the resulting radiation damage
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