507 research outputs found
I-fibrinogen as an oncophilic radiodiagnostic agent: distribution kinetics in tumour-bearing mice.
Fibrinogen radioiodinated by the iodine monochloride method was tested as a tumour radiodiagnostic agent in mice. The I-fibrinogen cleared from the blood of tumour-bearing mice more rapidly than from that of normal mice, but it cleared from the whole body more slowly, suggesting it accumulated in a substantial tumour-related compartment in the abnormal mice. The tumour concentration steadily increased for 4 h after injection, at which time it reached a peak concentration of 11-4% of the injected dose/g. This concentration was higher than the peak concentration for Ga-citrate (not reached until 24 h) or any other oncophilic radiopharmaceutical tested in this tumour model. The early accumulation is consistent with the use of 123I as a tracer label for fibrinogen. A combination of the large tumour concentration of I-fibrinogen, an increased catabolic rate induced by chemical modification, and the exceptional nuclear properties of 123I for scintigraphic imaging, could lead to a very useful radiodiagnostic procedure for cancer
Black Hole Evaporation in an Expanding Universe
We calculate the quantum radiation power of black holes which are asymptotic
to the Einstein-de Sitter universe at spatial and null infinities. We consider
two limiting mass accretion scenarios, no accretion and significant accretion.
We find that the radiation power strongly depends on not only the asymptotic
condition but also the mass accretion scenario. For the no accretion case, we
consider the Einstein-Straus solution, where a black hole of constant mass
resides in the dust Friedmann universe. We find negative cosmological
correction besides the expected redshift factor. This is given in terms of the
cubic root of ratio in size of the black hole to the cosmological horizon, so
that it is currently of order but could have been significant at the formation epoch of
primordial black holes. Due to the cosmological effects, this black hole has
not settled down to an equilibrium state. This cosmological correction may be
interpreted in an analogy with the radiation from a moving mirror in a flat
spacetime. For the significant accretion case, we consider the Sultana-Dyer
solution, where a black hole tends to increase its mass in proportion to the
cosmological scale factor. In this model, we find that the radiation power is
apparently the same as the Hawking radiation from the Schwarzschild black hole
of which mass is that of the growing mass at each moment. Hence, the energy
loss rate decreases and tends to vanish as time proceeds. Consequently, the
energy loss due to evaporation is insignificant compared to huge mass accretion
onto the black hole. Based on this model, we propose a definition of
quasi-equilibrium temperature for general conformal stationary black holes.Comment: Accepted for publication in Class.Quant.Grav., 18 pages and 3 figure
One-Loop Renormalization of a Self-Interacting Scalar Field in Nonsimply Connected Spacetimes
Using the effective potential, we study the one-loop renormalization of a
massive self-interacting scalar field at finite temperature in flat manifolds
with one or more compactified spatial dimensions. We prove that, owing to the
compactification and finite temperature, the renormalized physical parameters
of the theory (mass and coupling constant) acquire thermal and topological
contributions. In the case of one compactified spatial dimension at finite
temperature, we find that the corrections to the mass are positive, but those
to the coupling constant are negative. We discuss the possibility of
triviality, i.e. that the renormalized coupling constant goes to zero at some
temperature or at some radius of the compactified spatial dimension.Comment: 16 pages, plain LATE
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SPLENIC VOLUME CHANGE AND THERAPUETIC RESPONSE IN PATIENTS TREATED WITH RADIOMMUNOCONJUGATES
Splenomegaly is frequently found in non-Hodgkin's lymphoma (NHL) patients. This study evaluated the implications of splenic volume change in response to radioimmunotherapy (RIT). Twenty-nine NHL patients treated with radiolabeled-Lym-1 and 9 breast cancer patients (reference group) treated with radiolabeled-ChL6, BrE-3 or m170 were analyzed using CT splenic images obtained before and after RIT. Patient-specific radiation doses to spleen were determined using actual splenic volume determined by CT and body weight. In 13 of 29 NHL patients who had splenic volume {le} 310 ml, there was no or small change (-23 to 15 mL) in splenic volume, despite splenic doses as high as 14.4 Gy. Similarly, in a reference group of 9 breast cancer patients, there was no or small change (-5 to 13 mL), despite splenic doses as high as 11.4 Gy. In contrast, 13 of 29 NHL patients who had splenic volume 380-1400 mL, splenic volume decreased by 68 to 548 mL despite splenic doses as low as 1.40 Gy. Ten of 29 NHL patients with greater than a 15% decrease in splenic volume after RIT had nodal tumor regression (5 CR, 5 PR). In the remaining 19 NHL patients with less than a 15% decrease in splenic volume after RIT, there were 7 non-responders (5 CR and 7 PR). Splenic volume changes were found in NHL patients with splenomegaly. These splenic volume changes is likely due to therapeutic effect on malignant lymphocytes associated with splenomegaly. Nodal tumor response was more likely when splenomegaly decreased after RIT
Coarse-Graining and Renormalization Group in the Einstein Universe
The Kadanoff-Wilson renormalization group approach for a scalar
self-interacting field theor generally coupled with gravity is presented. An
average potential that monitors the fluctuations of the blocked field in
different scaling regimes is constructed in a nonflat background and explicitly
computed within the loop-expansion approximation for an Einstein universe. The
curvature turns out to be dominant in setting the crossover scale from a
double-peak and a symmetric distribution of the block variables. The evolution
of all the coupling constants generated by the blocking procedure is examined:
the renormalized trajectories agree with the standard perturbative results for
the relevant vertices near the ultraviolet fixed point, but new effective
interactions between gravity and matter are present. The flow of the conformal
coupling constant is therefore analyzed in the improved scheme and the infrared
fixed point is reached for arbitrary values of the renormalized parameters.Comment: 18 pages, REVTex, two uuencoded figures. (to appear in Phys. Rev.
D15, July) Transmission errors have been correcte
Effective Lagrangian for self-interacting scalar field theories in curved spacetime
We consider a self-interacting scalar field theory in a slowly varying
gravitational background field. Using zeta-function regularization and
heat-kernel techniques, we derive the one-loop effective Lagrangian up to
second order in the variation of the background field and up to quadratic terms
in the curvature tensors. Specializing to different spacetimes of physical
interest, the influence of the curvature on the phase transition is considered.Comment: 14 pages, LaTex, UTF 29
Oncogenic Kras-mediated cytokine CCL15 regulates pancreatic cancer cell migration and invasion through ROS
Pancreatic ductal adenocarcinoma (PDAC) is well known for its high death rate due to prompt cancer metastasis caused by cancer cell migration and invasion within the early stages of its development. Here, we reveal a new function of cytokine CCL15, namely the upregulation of PDAC cell migration and invasion. We showed increased levels of CCL15 transcripts and protein expressions in human PDAC tissue samples, as well as in cultured cell lines. Furthermore, PDAC cells also expressed CCL15 receptors, including CCR1 and CCR3. Murine PDAC cell lines and tissues strengthened this finding. The manipulation of CCL15 in metastatic Panc-1 cells through CCL15 knockdown or CCL15 neutralization decreased Panc-1 cell motility and invasiveness. In addition, treating non-metastatic BxPC-3 cells with recombinant CCL15 accelerated the cell migration of BxPC-3. A reduction in the levels of reactive oxygen species (ROS) by either N-Acetyl-L-Cysteine treatment or p22phox knockdown led to a decrease in Panc-1 cell migration and a reversed effect on recombinant CCL15-promoted BxPC-3 cell movement. Importantly, the knockdown of oncogenic Kras in Panc-1 cells abolished CCL15 protein expression and impeded cell migration without affecting PDAC cell growth. Altogether, our work elucidates an additional molecular pathway of oncogenic Kras to promote PDAC metastasis through the upregulation of cell migration and invasion by the Kras downstream CCL15, a lesser-known cytokine within the cancer research field
Some general properties of the renormalized stress-energy tensor for static quantum states on (n+1)-dimensional spherically symmetric black holes
We study the renormalized stress-energy tensor (RSET) for static quantum
states on (n+1)-dimensional, static, spherically symmetric black holes. By
solving the conservation equations, we are able to write the stress-energy
tensor in terms of a single unknown function of the radial co-ordinate, plus
two arbitrary constants. Conditions for the stress-energy tensor to be regular
at event horizons (including the extremal and ``ultra-extremal'' cases) are
then derived using generalized Kruskal-like co-ordinates. These results should
be useful for future calculations of the RSET for static quantum states on
spherically symmetric black hole geometries in any number of space-time
dimensions.Comment: 9 pages, no figures, RevTeX4, references added, accepted for
publication in General Relativity and Gravitatio
TAML/H2O2 oxidative degradation of metaldehyde: Pursuing better water treatment for the most persistent pollutants.
The extremely persistent molluscicide, metaldehyde, widely used on farms and gardens, is often detected in drinking water sources of various countries at concentrations of regulatory concern. Metaldehyde contamination restricts treatment options. Conventional technologies for remediating dilute organics in drinking water, activated carbon and ozone, are insufficiently effective against metaldehyde. Some treatment plants have resorted to effective, but more costly UV/H2O2. Here we have examined if TAML/H2O2 can decompose metaldehyde under laboratory conditions to guide development of a better real world option. TAML/H2O2 slowly degrades metaldehyde to acetaldehyde and acetic acid. Nuclear magnetic resonance spectroscopy ((1)H NMR) was used to monitor the degradation-the technique requires a high metaldehyde concentration (60 ppm). Within the pH range of 6.5-9, the reaction rate is greatest at pH 7. Under optimum conditions, one aliquot of TAML 1a (400 nM) catalyzed 5% degradation over 10 hours with a turnover number of 40. Five sequential TAML aliquots (2 ÎŒM overall) effected a 31% removal over 60 hours. TAML/H2O2 degraded metaldehyde steadily over many hours, highlighting an important long-service property. The observation of metaldehyde decomposition under mild conditions provides a further indication that TAML catalysis holds promise for advancing water treatment. These results have turned our attention to more aggressive TAML activators in development, which we expect will advance the observed technical performance
Poincare gauge invariance and gravitation in Minkowski spacetime
A formulation of Poincare symmetry as an inner symmetry of field theories
defined on a fixed Minkowski spacetime is given. Local P gauge transformations
and the corresponding covariant derivative with P gauge fields are introduced.
The renormalization properties of scalar, spinor and vector fields in P gauge
field backgrounds are determined. A minimal gauge field dynamics consistent
with the renormalization constraints is given.Comment: 36 pages, latex-fil
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