EFFECT OF SOME MAJOR ELEMENTS ON GROWTH PERFORMANCE AND BLOOD PARAMETERS IN FISH

he present experiment was conducted to determine the optimal source and level of phosphorus supplementation in commercial feeds with the highest growth rate and the lowest releasing in environmental and protect water quality of Nile Juveniles tilapia (Oreochromis niloticus). Fish were divided into twelve groups (groups) each group was stocked into two aquaria each contains 10 fish.  Fish were fed diet contained different levels of phosphorus (0.005, 0.007, 0.009 and 0.011%Kg diet phosphorus) from   three different sources of phosphorus (mono calcium phosphate, mono potassium phosphate and mono sodium phosphate) for a period of 12 weeks. Results showed that average daily gain, specific growth rate, protein efficiency ratio and feed conversation ratio were significantly improved at (p) 1.1% dietary phosphorus level with mono sodium phosphate as the source of phosphorus, mono calcium phosphate represented the highest significant (P<0.05) value of growth and blood parameters (Packed cell volume (PCV), Hemoglobein(Hb) ,red blood cell(RBC) and white blood cell(WBC) in Oreochromis niloticus .  Concerning levels of phosphorus the result clearly indicated that the 0.9% phosphorus level recorded the significant (P<0.05) highest growth and blood parameters in Oreochromis niloticus. Body composition analysis showed that the whole body protein and ash content were increased linearly but lipid was decreased (P<0.05) with increasing dietary of phosphorus

Revue systématique sur le taux de survie des implants en zircone

Le but de ce travail était de pouvoir évaluer à la fois les taux de succès et de survie des implants céramiques en zircone une année après leur mise en charge et de juger en fonction de l'évidence scientifique si ceux-ci peuvent être considérés comme une alternative aux implants en titane. Une recherche électronique dans plusieurs bases de données a permis d'identifier 1519 articles initialement. Cependant, seuls 14 d'entre eux ont été retenus. Après une année de fonction, le taux de survie global des implants en zircone une et deux pièces a été calculé à 92%. L'analyse détaillée des études sélectionnées a mis en évidence considérable hétérogénéité concernant les taux de survie. Il a été conclu que les implants en zircone pourraient représenter une alternative au titane afin de proposer une solution « sans–métal ». Néanmoins, des résultats à long terme sont nécessaires afin de justifier leur utilisation

A comprehensive review of peri-implantitis risk factors

Purpose of Review: This is a comprehensive narrative review aimed at identifying relevant risk factors associated with peri-implantitis. Recent Findings: Recent studies suggest that water pipes and electronic cigarettes present potentially significant risk factors for peri-implantitis. In addition, we have recently appreciated that the release of titanium particles into the peri-implant tissues is associated with inflammation and disease progression. Yet the question remains as to whether these factors could be sole or major causes of peri-implantitis, or merely additional factors contributing to the aggravation of the disease. Furthermore, the use of zirconia implants does not prevent the development of peri-implantitis, but it has been associated with lower inflammation and marginal bone resorption. Summary: Established peri-implantitis risk factors include periodontal disease, lack of maintenance, cigarette and smokeless tobacco use, hyperglycaemia and obesity. Local risk factors include inadequate plaque control, mucositis, implant’s malposition and poorly designed prostheses or presence of excess cement. Potential risk factors requiring additional research include genetic and systemic conditions, high doses of bisphosphonates and hormonal replacement therapy. Occlusal overload, lack of keratinised tissue and local presence of titanium particles seem to aggravate peri-implant disease, but studies are still required prior to drawing definitive conclusions

Zirconia dental implants: where are we now, and where are we heading?

Despite decades of titanium as the gold standard in oral implantology, the search for alternatives has been growing. High esthetic standards and increasing incidence of titanium allergies, along with a rising demand for metal-free reconstructions, have led to the proposal of ceramics as potential surrogates. Following numerous experimental studies, zirconium dioxide (zirconia) has earned its place as a potential substitute for titanium in implantology. Yet, despite zirconia's excellent biocompatibility and tissue integration, low affinity to plaque and favorable biomechanical properties, early failures were significantly higher for zirconia implants than for titanium implants. Technical failure as a result of fracture of the material is also a major concern. So far, zirconia implants have been mainly manufactured as one-piece implant systems because of the material's limitations. Nevertheless, various two-piece systems have been progressively emerging with promising results. Screw-retained abutments are desirable but present a major technical challenge. Innovation and technical advances will undoubtedly lead to further improvement in the reliability and strength of zirconia implants, allowing for novel designs, connections and reconstructions. Additional clinical studies are required to identify all relevant technical and biological factors affecting implant success and patients' satisfaction. However, the evidence for a final verdict is, at present, still incomplete

The diagnosis of peri-implantitis: A systematic review on the predictive value of bleeding on probing

Bleeding on gentle probing (BOP) is the key parameter to the diagnosis of mucositis, while changes in crestal bone levels, along with clinical signs of inflammation, are required for the diagnosis of peri-implantitis. This systematic review and meta-analysis focused on the evaluation of BOP as a predictive measure for peri-implantitis

A systematic review of the clinical survival of zirconia implants

OBJECTIVES: The aim of this review was to evaluate the clinical success and survival rates of zirconia ceramic implants after at least 1 year of function and to assess if there is sufficient evidence to justify using them as alternatives to titanium implants. MATERIALS AND METHODS: An electronic search in MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Clinical Trials (CENTRAL) databases was performed in April 2015 by two independent examiners to retrieve clinical studies focusing on the survival rate of zirconia implants after at least 1 year of function. Implant survival was estimated using the overall proportion reported in the studies with a Clopper-Pearson 95 % confidence interval (random effect model with a Der-Simonian Laird estimate). RESULTS: Fourteen articles were selected out of the 1519 titles initially screened. The overall survival rate of zirconia one- and two-piece implants was calculated at 92 % (95 % CI 87-95) after 1 year of function. The survival of implants at 1 year for the selected studies revealed considerable heterogeneity. CONCLUSIONS: In spite of the unavailability of sufficient long-term evidence to justify using zirconia oral implants, zirconia ceramics could potentially be the alternative to titanium for a non-metallic implant solution. However, further clinical studies are required to establish long-term results, and to determine the risk of technical and biological complications. Additional randomized controlled clinical trials examining two-piece zirconia implant systems are also required to assess their survival and success rates in comparison with titanium as well as one-piece zirconia implants. CLINICAL RELEVANCE: Zirconia implants provide a potential alternative to titanium ones. However, clinicians must be aware of the lack of knowledge regarding long-term outcomes and specific reasons for failure

Quantification of titanium and zirconium elements in oral mucosa around healthy dental implants : a case-control pilot study

Objectives: Metallic particles are detected in different sites of the oral cavity, mainly in patients with peri-implantitis lesions. The aim of this pilot study was to analyze the levels of titanium and zirconium elements in the oral mucosa around healthy implants and to investigate the impact of titanium exogenous contamination on the measurements. Materials and methods: Forty-one participants were included in this three-phase study. Two groups of subjects were defined according to presence of titanium or zirconia implants (n: 20) or without any implants nor metallic restorations (n:21). Thirteen patients (n: 5 with zirconia implant; n: 3 with titanium implants; n: 5 control group) took part to the first part designed to optimize and validate the method of detecting titanium (Ti) and zirconium (Zr) elements in the oral mucosa and gingival tissues by the Inductively Coupled Plasma Mass Spectrometry (ICPMS). The second phase compared the levels of Ti and Zr concentrations in patients with implants (n: 12) and without implants (n: 6) who were controlled for their intake of titanium dioxide (TiO2). The last step included ten control subjects without any metallic devices to measure the concentration of Ti and Zr before and after having candies containing TiO2. Results: In the first phase, concentrations of Ti and Zr were below the limit of detection (LOD) in most cases, 0.18 μg/L and 0.07 μg/L respectively. In the titanium group, two out of three subjects displayed concentrations above the LOD, 0.21 μg/L and 0.66 μg/L. Zr element was only found in patients with zirconia implants. After controlling the intake of TiO2, all concentrations of Ti and Zr were below the limit of quantification (LOQ). Moreover, in patients with no implants, the Ti concentration in gingiva cells was superior for 75% of the samples after having a TiO2 diet. Conclusions: Zirconium was only found in patients with zirconia implants, whereas titanium was detected in all groups even in subjects with no titanium implants. Zirconium and titanium elements were not detected in patients who were controlled for their intake of food and their use of toothpaste irrespective of the presence of implants or not. For 70% of the patients, the titanium detection was directly influenced by the intake of TiO2 contained candies. Clinical relevance: When analyzing titanium particles, it is necessary to pay attention to the risk of contamination bias brought by external products. When this parameter was controlled, no titanium particles were detected around clinically healthy implants.</p

Pro-inflammatory cytokines at zirconia implants and teeth. A cross-sectional assessment

OBJECTIVES: The aim of this study was to compare the expression of host-derived markers in peri-implant/gingival crevicular fluid (PCF/GCF) and clinical conditions at ceramic implants and contralateral natural teeth. As a secondary objective, we compared zirconia implants with titanium implants. METHODS: One zirconia implant (ZERAMEX(R) Implant System) and one contralateral natural tooth were examined in 36 systemically healthy subjects (21 males, 15 females, mean age 58). The levels of Il-1beta, Il-1RA, Il-6, Il-8, Il-17, b-FGF, G-CSF, GM-CSF, IFN, MIP-1beta, TNF-alpha, and VEGF were assessed in PCF/GCF using the Bio-Plex 200 Suspension Array System. The plaque index (PI), gingival index (GI), probing depth (PD), and bleeding on probing (BOP) were assessed at six sites around each implant or tooth. Titanium implants were also assessed when present (n = 9). RESULTS: The zirconia implants were examined after a loading period of at least 1.2 years (average 2.2 years). The mean PI was significantly lower at zirconia implants compared to teeth (p = 0.003), while the mean GI, PD, and BOP were significantly higher (p < 0.001). A correlation was found in the expression of Il-1RA, Il-8, G-CSF, MIP-1beta, and TNF-alpha at zirconia implants and teeth. The levels of IL-1beta and TNF-alpha were significantly higher at zirconia implants than at teeth. No significant differences were found between zirconia and titanium implants. A correlation was found between the levels of IL-1RA, IL-8, GM-CSF, and MIP-1beta at zirconia and titanium implants. CONCLUSIONS: The correlation in the expression of five biomarkers at zirconia implants and teeth, and of four biomarkers at zirconia and titanium implants, is compatible with the existence of a patient-specific inflammatory response pattern. Higher mean GI, PD, and BOP around implants suggests that the peri-implant mucosa may be mechanically more fragile than the gingiva. CLINICAL RELEVANCE: Similar expression of selected biomarkers at zirconia implants and teeth and at zirconia and titanium implants reflects existence of patient-specific inflammatory response patterns

Group 4 ITI Consensus Report: Risks and biologic complications associated with implant dentistry.

OBJECTIVES The aim of Working Group 4 was to address topics related to biologic risks and complications associated with implant dentistry. Focused questions on (a) diagnosis of peri-implantitis, (b) complications associated with implants in augmented sites, (c) outcomes following treatment of peri-implantitis, and (d) implant therapy in geriatric patients and/or patients with systemic diseases were addressed. MATERIALS AND METHODS Four systematic reviews formed the basis for discussion in Group 4. Participants developed statements and recommendations determined by group consensus based on the findings of the systematic reviews. These were then presented and accepted following further discussion and modifications as required by the plenary. RESULTS Bleeding on probing (BOP) alone is insufficient for the diagnosis of peri-implantitis. The positive predictive value of BOP alone for the diagnosis of peri-implantitis varies and is dependent on the prevalence of peri-implantitis within the population. For patients with implants in augmented sites, the prevalence of peri-implantitis and implant loss is low over the medium to long term. Peri-implantitis treatment protocols which include individualized supportive care result in high survival of implants after 5 years with about three-quarters of implants still present. Advanced age alone is not a contraindication for implant therapy. Implant placement in patients with cancer receiving high-dose antiresorptive therapy is contraindicated due to the associated high risk for complications. CONCLUSIONS Diagnosis of peri-implantitis requires the presence of BOP as well as progressive bone loss. Prevalence of peri-implantitis for implants in augmented sites is low. Peri-implantitis treatment should be followed by individualized supportive care. Implant therapy for geriatric patients is not contraindicated; however, comorbidities and autonomy should be considered