Communications Biophysics

Contains reports on four research projects.National Institutes of Health (Grant 1 P01 GM-14940-01)Joint Services Electronics Programs (U.S. Army, U.S. Navy, and U.S. Air Force) under Contract DA 28-043-AMC-02536(E)National Aeronautics and Space Administration (Grant NsG-496)National Institutes of Health (Grant 1 TO1 GM-01555-01

Application of the Thermal Flash Technique for Low Thermal Diffusivity Micro/Nanofibers

The thermal flash method was developed to characterize the thermal diffusivity of micro/nanofibers without concern for thermal contact resistance, which is commonly a barrier to accurate thermal measurement of these materials. Within a scanning electron microscope, a micromanipulator supplies instantaneous heating to the micro/nanofiber, and the resulting transient thermal response is detected at a microfabricated silicon sensor. These data are used to determine thermal diffusivity. Glass fibers of diameter 15 mu m had a measured diffusivity of 1.21x10(-7) m(2)/s; polyimide fibers of diameters 570 and 271 nm exhibited diffusivities of 5.97x10(-8) and 6.28x10(-8) m(2)/s, respectively, which compare favorably with bulk values

Cryogenic System for a High Temperature Superconducting Power Transmission Cable

High-temperature superconducting (HTS) cable systems for power transmission are under development that will use pressurized liquid nitrogen to provide cooling of the cable and termination hardware. Southwire Company and Oak Ridge National Laboratory have been operating a prototype HTS cable system that contains many of the typical components needed for a commercial power transmission application. It is being used to conduct research in the development of components and systems for eventual commercial deployment. The cryogenic system was built by Air Products and Chemicals, Allentown, Pennsylvania, and can circulate up to 0.35 kg/s of liquid nitrogen at temperatures as low as 67 K at pressures of 1 to 10 bars. Sufficient cooling is provided for testing a 5-m-long HTS transmission cable system that includes the terminations required for room temperature electrical connections. Testing of the 5-m HTS transmission cable has been conducted at the design ac conditions of 1250 A and 7.5 kV line to ground. This paper contains a description of the essential features of the HTS cable cryogenic system and performance results obtained during operation of the system. The salient features of the operation that are important in large commercial HTS cable applications will be discussed

Communications Biophysics

Contains reports on five research projects.National Institutes of Health (Grant 5 P01 GM14940-03)National Institutes of Health (Grant 5 TOl GM01555-03)National Aeronautics and Space Administration (Grant NGL 22-009-304

Test of two prototype high-temperature superconducting transmission cables

Two 500-A class prototype high-temperature superconducting cables have been constructed by Southwire Company and tested at Oak Ridge National Laboratory (ORNL). In the first cable, no insulation was used to separate the individual HTS tapes. In the second cable, Kapton tape was used to insulate the HTS tapes between successive layers for the study of AC loss and current distribution. The cables were tested with both DC and AC currents in liquid nitrogen from 77 to 69 K. Both cables achieved DC critical current, I{sub c} greater than 500 A. A calorimetric technique that measures the cable temperature rise under ac currents was used to measure the ac loss of the cables. The un-insulated cable showed a cryoresistive behavior under the 60 Hz AC currents. The insulated cable started to show measurable loss at current where there was corresponding resistive loss

Making Almost Commuting Matrices Commute

Suppose two Hermitian matrices $A,B$ almost commute ($\Vert [A,B] \Vert \leq \delta$). Are they close to a commuting pair of Hermitian matrices, $A',B'$, with $\Vert A-A' \Vert,\Vert B-B'\Vert \leq \epsilon$? A theorem of H. Lin shows that this is uniformly true, in that for every $\epsilon>0$ there exists a $\delta>0$, independent of the size $N$ of the matrices, for which almost commuting implies being close to a commuting pair. However, this theorem does not specify how $\delta$ depends on $\epsilon$. We give uniform bounds relating $\delta$ and $\epsilon$. We provide tighter bounds in the case of block tridiagonal and tridiagonal matrices and a fully constructive method in that case. Within the context of quantum measurement, this implies an algorithm to construct a basis in which we can make a {\it projective} measurement that approximately measures two approximately commuting operators simultaneously. Finally, we comment briefly on the case of approximately measuring three or more approximately commuting operators using POVMs (positive operator-valued measures) instead of projective measurements.Comment: 22 pages; tighter bounds; Note: fixed mistake in proof pointed out by Filonov and Kachkovski

Communications Biophysics

Contains research objectives, summary of research and reports on three research projects.National Institutes of Health (Grant 5 PO1 GM14940-04)National Institutes of Health (Grant 5 TOl GM01555-04)National Aeronautics and Space Administration (Grant NGL 22-009-304

Impact of high-risk prenatal screening results for 22q11.2 deletion syndrome on obstetric and neonatal management: Secondary analysis from the SMART study

Objective One goal of prenatal genetic screening is to optimize perinatal care and improve infant outcomes. We sought to determine whether high-risk cfDNA screening for 22q11.2 deletion syndrome (22q11.2DS) affected prenatal or neonatal management. Methods This was a secondary analysis from the SMART study. Patients with high-risk cfDNA results for 22q11.2DS were compared with the low-risk cohort for pregnancy characteristics and obstetrical management. To assess differences in neonatal care, we compared high-risk neonates without prenatal genetic confirmation with a 1:1 matched low-risk cohort. Results Of 18,020 eligible participants enrolled between 2015 and 2019, 38 (0.21%) were high-risk and 17,982 (99.79%) were low-risk for 22q11.2DS by cfDNA screening. High-risk participants had more prenatal diagnostic testing (55.3%; 21/38 vs. 2.0%; 352/17,982, p < 0.001) and fetal echocardiography (76.9%; 10/13 vs. 19.6%; 10/51, p < 0.001). High-risk newborns without prenatal diagnostic testing had higher rates of neonatal genetic testing (46.2%; 6/13 vs. 0%; 0/51, P < 0.001), echocardiography (30.8%; 4/13 vs. 4.0%; 2/50, p = 0.013), evaluation of calcium levels (46.2%; 6/13 vs. 4.1%; 2/49, P < 0.001) and lymphocyte count (53.8%; 7/13 vs. 15.7%; 8/51, p = 0.008). Conclusions High-risk screening results for 22q11.2DS were associated with higher rates of prenatal and neonatal diagnostic genetic testing and other 22q11.2DS-specific evaluations. However, these interventions were not universally performed, and >50% of high-risk infants were discharged without genetic testing, representing possible missed opportunities to improve outcomes for affected individuals