Examination of the Relationship between Umbilical Cord Blood Gas Values and Hearing Function in Neonates

Objective: The aim of the present study was to examine the relationship between the results of the transient otoacoustic emission (TEOAE) test used in neonatal hearing screening and the results of the umbilical cord blood (UCB) analysis in neonates.Methods: This retrospective study included 209 neonates born in the obstetric unit at the 37th gestational week. Based on the results of the TEOAE test, the neonates included in the study were divided into two groups as the study group composed of those “REFER” (n=141) and the control group consisting those “PASS” (n=68) the test. The UCB sampling procedure was performed on all neonates. In the blood samples, the pH parameters were evaluated by using glass electrodes, and the pCO2 and pO2 parameters were evaluated directly by using sensitive electrodes.Results: When the additional maternal diseases were compared with the TEOAE results, the ratio of hypothyroidism was found to be statistically higher in the study group (p0.05).Conclusion: The results of the present study showed that there was no statistically significant difference between the results of UCB analysis and the TEOAE test. However, we believe that conducting a larger study evaluating other parameters and employing UCB analysis would be useful, and UCB evaluation, which is an inexpensive, easy and effective method in determining hypoxia in neonates, might be a significant marker in cases at risk of hearing loss

Kardiyovasküler Cerrahi Sonrası Gelişen Akut Böbrek Yetmezliğinin Tanısında Kullanılan Erken Dönem Belirteçler

Kalp cerrahisinde en önemli postoperatif sorunlardan biri akut böbrek yetmezliğidir (ABY). Özellikle erken dönem gelişen ABY hasta mortalite ve morbiditesi üzerinde etkilidir. Rutinde kullanılan serum üre ve kreatinin değerlerinin böbrek hasarından 24-72 saat sonra yükselmesi nedeniyle; bir çok araştırmacı ABY’nin daha erken teşhis edilebilmesi için, yeni belirteçler araştırmaktadır. Bu çalışmanın amacı kalp cerrahisi sonrası gelişen ABY’nin erken tanısında kullanılabilecek biyobelirteçleri güncel literatür ışığında tartışmaktır

Prognostic role of soluble suppression of tumorigenicity-2 on cardiovascular mortality in outpatients with heart failure

Objective: Soluble suppression of tumorigenicity-2 (sST2), a member of the interleukin 1 receptor family, is increased in mechanical stress conditions and is produced by cardiomyocytes and cardiac fibroblasts. Elevated sST2 level is associated with the prognosis of acute coronary syndrome, pulmonary arterial hypertension, and acute and chronic heart failure (HF). In this study, we aimed to investigate the relationship between sST2 levels and cardiovascular mortality in outpatients with HF

Evaulation of Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 Levels in Acute and Subacute Periods of Ischemic Stroke

Objective: Atherosclerosis and inflammatory mechanisms play an important role in the pathogenesis of cerebral isch­emia. The activity of Matrix metalloproteinases (MMP) is essential for many of the processes involved in atherosclerotic plaque formation, such as infiltration of inflammatory cells, smooth muscle cell migration and proliferation. There are a few studies referring to the importance of MMP-2 and MMP-9 levels for the stroke severity and prognosis in acute ischemic stroke In this study, MMP-2 and MMP-9 levels in acute and subacute periods and the relationship between Glasgow coma scale (GCS) will was assessed. Methods: Seventy ischemic stroke patients who fulfilled the study criteria are included to our study prospectively. Serum MMP-2 and MMP-9 antibody levels calculated by ELISA method at period of the acute and subacute ischemic stroke. Results: Average serum MMP2 antibody levels are 4.28 ± 3.36 acute period and 2.27 ± 2.62 (p˂0.05) in subacute period. Also average serum MMP9 antibody levels are 4.28 ± 3.36 acute period and 2.83 ± 3.83 (p˂0.05). It was not observed correlation between MMP-2 and MMP-9 levels and GCS. Conclusion: These results suggest that MMP-2 levels in the patients with ischemic stroke show a statistically significant difference when compared acute and subacute period. We conclude that MMP-2 may important role on the ischemic stroke