Effectiveness Study On longitudinal Laboratory monitoring Of the INR in Patients Receiving Vitamin-K Antagonist For Atrial Fibrilation in R.Macedonia

Atrial fibrillation is preventable cause for ischemic stroke and various other thrombo-embolic events. One of the main agents used in the prevention of the consequences are the vitamin-K antagonists. Although efficacy is proven, studies have questioned their efficiency in this setting. Various factors contribute to variations of their efficiency, which is still underinvestigated in many health systems. Few studies have shown varied estimates and cited different reasons for its effectiveness, ranging from subtle differences in diet, concurrent medications use, variable level of enzyme activity to age and compliance of users, which can vary unexpectedly. The aim of the present study of effectiveness is to describe how often patients that use VKA achieve the targeted values for INR. The population consists of the hospital reach area of Clinical Hospital Tetovo, observed for 6 months with routine laboratory investigation for the values of INR. Our study reveals that 57.4% of all measurements of INR where within the target values between 2-3, while 9.7% of all measurements revealed extreme values that can put patients at risk for further thrombo-embolic events or catastrophic hemorrhagic events