Hybrid Graphene Oxide Based Plasmonic-Magnetic Multifunctional Nanoplatform for Selective Separation and Label-Free Identification of Alzheimer’s Disease Biomarkers

Despite intense efforts, Alzheimer’s disease (AD) is one of the top public health crisis for society even at 21st century. Since presently there is no cure for AD, early diagnosis of possible AD biomarkers is crucial for the society. Driven by the need, the current manuscript reports the development of magnetic core-plasmonic shell nanoparticle attached hybrid graphene oxide based multifunctional nanoplatform which has the capability for highly selective separation of AD biomarkers from whole blood sample, followed by label-free surface enhanced Raman spectroscopy (SERS) identification in femto gram level. Experimental ELISA data show that antibody-conjugated nanoplatform has the capability to capture more than 98% AD biomarkers from the whole blood sample. Reported result shows that nanoplatform can be used for SERS “fingerprint” identification of β-amyloid and tau protein after magnetic separation even at 100 fg/mL level. Experimental results indicate that very high sensitivity achieved is mainly due to the strong plasmon-coupling which generates huge amplified electromagnetic fields at the “hot spot”. Experimental results with nontargeted HSA protein, which is one of the most abundant protein components in cerebrospinal fluid (CSF), show that multifunctional nanoplatform based AD biomarkers separation and identification is highly selective

FAPbI\u3csub\u3e3\u3c/sub\u3e Perovskite Films Prepared by Solvent Self-Volatilization for Photovoltaic Applications

Developing a simple method to synthesize the perovskite layer without the antisolvent technique can facilitate the industrial production of perovskite solar cells (PSCs). Limited progress has been made for the antisolvent-free method on formamidinium lead triiodide perovskite layers because of the phase stability issue. Here, we use N-methyl pyrrolidone (NMP) as an additive to inhibit the nonperovskite phase of FAPbI3 to fabricate the formamidinium iodide (FAI)–PbI2–NMP intermediate phase via the self-volatilization of volatile solvent 2-methoxyethanol instead of the traditional antisolvent method. The high-quality pure α phase of FAPbI3 films is obtained by phase transition via annealing. The photovoltaic properties of the perovskite films affected by different NMP amounts are studied. The corresponding PSCs show a PCE of 20.1% compared to 15.6% for the PSCs fabricated with the classical antisolvent technique. The unencapsulated devices exhibit ∼75% efficiency of their initial PCE values after 35 days of storage. This method can be used in the scalable production of PSCs because of high reproducibility and easy operation