Mitochondrial fission regulates germ cell differentiation by suppressing ROS-mediated activation of Epidermal Growth Factor Signaling in the Drosophila larval testis.

Mitochondria are essential organelles that have recently emerged as hubs for several metabolic and signaling pathways in the cell. Mitochondrial morphology is regulated by constant fusion and fission events to maintain a functional mitochondrial network and to remodel the mitochondrial network in response to external stimuli. Although the role of mitochondria in later stages of spermatogenesis has been investigated in depth, the role of mitochondrial dynamics in regulating early germ cell behavior is relatively less-well understood. We previously demonstrated that mitochondrial fusion is required for germline stem cell (GSC) maintenance in the Drosophila testis. Here, we show that mitochondrial fission is also important for regulating the maintenance of early germ cells in larval testes. Inhibition of Drp1 in early germ cells resulted in the loss of GSCs and spermatogonia due to the accumulation of reactive oxygen species (ROS) and activation of the EGFR pathway in adjacent somatic cyst cells. EGFR activation contributed to premature germ cell differentiation. Our data provide insights into how mitochondrial dynamics can impact germ cell maintenance and differentiation via distinct mechanisms throughout development

Strongly interacting bosons in a disordered optical lattice

Disorder, prevalent in nature, is intimately involved in such spectacular effects as the fractional quantum Hall effect and vortex pinning in type-II superconductors. Understanding the role of disorder is therefore of fundamental interest to materials research and condensed matter physics. Universal behavior, such as Anderson localization, in disordered non-interacting systems is well understood. But, the effects of disorder combined with strong interactions remains an outstanding challenge to theory. Here, we experimentally probe a paradigm for disordered, strongly-correlated bosonic systems-the disordered Bose-Hubbard (DBH) model-using a Bose-Einstein condensate (BEC) of ultra-cold atoms trapped in a completely characterized disordered optical lattice. We determine that disorder suppresses condensate fraction for superfluid (SF) or coexisting SF and Mott insulator (MI) phases by independently varying the disorder strength and the ratio of tunneling to interaction energy. In the future, these results can constrain theories of the DBH model and be extended to study disorder for strongly-correlated fermionic particles.Comment: 15 pages, 4 figures updated to correct errors in referencing previous wor

A seed specific dose kernel method for low-energy brachytherapy dosimetry.

We describe a method for independently verifying the dose distributions from pre- and post-implant brachytherapy source distributions. Monte Carlo calculations have been performed to characterize the three-dimensional dose distribution in water phantom from a low-energy brachytherapy source. The calculations are performed in a voxelized, Cartesian coordinate geometry and normalized based upon a separate Monte Carlo calculation for the seed specific air-kerma strength to produce an absolute dose grid with units of cGy hr(-1) x U(-1). The seed-specific, three-dimensional dose grid is stored as a text file for processing using a separate visual basic program. This program requires the coordinate positions of each seed in the pre- or post-plan and sums the kernel file for a three-dimensional composite dose distribution. A kernel matrix size of 81x81x81 with a voxel size of 1.0x1.0x1.0 mm3 was chosen as a compromise between calculation time, kernel size, and truncation of the stored dose distribution as a function of radial distance from the midpoint of the seed. Good agreement is achieved for a representative pre- and post-plan comparison versus a commercial implementation of the TG-43 brachytherapy dosimetry protocol

Limits to Sympathetic Evaporative Cooling of a Two-Component Fermi Gas

We find a limit cycle in a quasi-equilibrium model of evaporative cooling of a two-component fermion gas. The existence of such a limit cycle represents an obstruction to reaching the quantum ground state evaporatively. We show that evaporatively the \beta\mu ~ 1. We speculate that one may be able to cool an atomic fermi gas further by photoassociating dimers near the bottom of the fermi sea.Comment: Submitted to Phys. Rev

Rapidly Rotating Fermi Gases

We show that the density profile of a Fermi gas in rapidly rotating potential will develop prominent features reflecting the underlying Landau level like energy spectrum. Depending on the aspect ratio of the trap, these features can be a sequence of ellipsoidal volumes or a sequence of quantized steps.Comment: 4 pages, 1 postscript fil

Low energy collective excitations in a superfluid trapped Fermi gas

We study low energy collective excitations in a trapped superfluid Fermi gas, that describe slow variations of the phase of the superfluid order parameter. Well below the critical temperature the corresponding eigenfrequencies turn out to be of the order of the trap frequency, and these modes manifest themselves as the eigenmodes of the density fluctuations of the gas sample. The latter could provide an experimental evidence of the presence of the superfluid phase.Comment: 5 pages, REVTeX, referencies correcte

Collective Modes in a Dilute Bose-Fermi Mixture

We here study the collective excitations of a dilute spin-polarized Bose-Fermi mixture at zero temperature, considering in particular the features arising from the interaction between the two species. We show that a propagating zero-sound mode is possible for the fermions even when they do not interact among themselves.Comment: latex, 6 eps figure

Evaporative Cooling of a Two-Component Degenerate Fermi Gas

We derive a quantum theory of evaporative cooling for a degenerate Fermi gas with two constituents and show that the optimum cooling trajectory is influenced significantly by the quantum statistics of the particles. The cooling efficiency is reduced at low temperatures due to Pauli blocking of available final states in each binary collision event. We compare the theoretical optimum trajectory with experimental data on cooling a quantum degenerate cloud of potassium-40, and show that temperatures as low as 0.3 times the Fermi temperature can now be achieved.Comment: 6 pages, 4 figure