Sotalol poisoning associated with asystole

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Hyponatremia and atrial natriuretic peptide secretion in patients with vasopressin-induced natriuresis

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The reply

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Psychosis and water metabolism

To the Editor: Goldman et al. (Feb. 18 issue)1 report new and important information about psychosis and water metabolism. The focus of their paper was on altered thirst and osmotic regulation. In a previous study, these investigators demonstrated a correlation between changes in serum sodium levels and changes in body weight (r = -0.74) among patients with chronic psychosis who were subject to water intoxication.2 We (r = -0.95),3 Koczapski et al. (r = -0.89),4 and Delva and Crammer (r between -0.65 and -0.99)5 have also found strong correlations between changes in serum sodium levels and body weight. However, the. © 1988, Massachusetts Medical Society. All rights reserved.LetterSCOPUS: le.jinfo:eu-repo/semantics/publishe

Involvement of atrial natriuretic factor and natriuresis in the volume adjustment to acute water intake in man

33rd International Henri-Pierre Klotz Days of Clinical Endocrinology (Paris, Mai 1990)info:eu-repo/semantics/publishe

Water induced natriuresis and atrial natriuretic factor secretion in healthy humans: modulation by the sodium intake

23rd Annual Scientific Meeting of the European Society for Clinical Investigation (Athens, Greece, April 1989)info:eu-repo/semantics/publishe

Lung abscess due to Eikenella corrodens: Three cases and review [2]

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Disposition of liposomal gentamicin following intrabronchial administration in rabbits.

Use of liposomes as carriers of gentamicin for intrabronchial pulmonary delivery was investigated in rabbits. Gentamicin, in isotonic glutamic acid buffer, pH 4.5, was encapsulated in multilamellar vesicles (MLVs) and administered intrabronchially. Higher drug concentrations were found at the pulmonary site of liposome instillation for 1 day as compared with free unencapsulated antibiotic. When time-course distributions of gentamicin given in the liposomal or free form were measured in bronchoalveolar lavages (BAL), similar accumulations were observed up to 4 h, but the drug remained longer (24 h) after administration of the liposomal formulation. Higher amounts of antibiotic were detected in BAL supernatant 1 h after instillation of plain gentamicin; this difference stopped being significant after 4 h. A microbiological assay outlined the bacteriostatic activity of gentamicin released from MLVs and recovered in BAL supernatant. Liposomal gentamicin accumulated in the BAL cell pellet 1 h after intrabronchial instillation; it decreased progressively but minute amounts were still detected after 1 day. On the contrary, no gentamicin was found in the pellet at any time after free drug administration. Comparison of aminoglycoside concentrations in plasma and kidneys indicated lower and constant levels when the liposomal form was instilled. Liposome encapsulation altered the disposition of gentamicin in a way suggesting improved pulmonary concentration and lower systemic toxicity.Journal ArticleResearch Support, Non-U.S. Gov'tSCOPUS: ar.jinfo:eu-repo/semantics/publishe