174 research outputs found
Do radiolucent lines and stress shielding of the humeral shaft really matter in shoulder arthroplasty?
The purpose of this study is to evaluate at a mid-term follow up, the radiological survival of an
uncemented humeral stem in shoulder arthroplasty. One hundred and twenty-six replacements
including hemi (HA), total (TSA) and reverse (RSA) implanted from 1999 to 2008 were reviewed at
a mean follow up of 7.2 years (48-144 months). The same uncemented triconical stem (SMR, Lima
Corporate) was implanted. There were: 23 HSA, 43 TSA, 60 RSA. An independent observer evaluated
all the patients with Constant Score. A radiologic analysis by an expert radiologist and an orthopaedic
surgeon was performed: humeral component-bone interface was divided in seven zones. They judged
a mobilisation if a migration or tilt of the humeral implant or if≥ 2 mm radiolucent line in at least
three zones was present. Chi-squared test, Fisher test and analysis of variance were performed and
a p<0.05 was considered statistically significant. No major radiological signs of loosening and no tilt
or migration of the humeral component were found. Only 23 (18.2%) patients had no RL around the
humeral implant. In the remaining 103 (81.7%) implants: 96 (76.1%) presented RL less than 2 mm,
particularly 75 (59.5%) in less than 3 zones and 21 (16.6%) in more than 3 zones. Of the remaining 7
(5.5%) implants the presence of RL of 2 mm or greater in only one zone was seen. Apart from sepsis
no revision was performed for humeral component loosening. Although a high rate of RL, uncemented
humeral stem has an excellent survivorship at a mid-term follow up. Relationship between presence,
position and depth of RL and internal stress shielding is commonly observed but does not appear t
Risk factors for recurrence in patients with Clostridium difficile infection due to 027 and non-027 ribotypes
Objectives: Our objective was to evaluate factors associated with recurrence in patients with 027+ and 027– Clostridium difficile infection (CDI). Methods: Patients with CDI observed between January and December 2014 in six hospitals were consecutively included in the study. The 027 ribotype was deduced by the presence of tcdB, tcdB, cdt genes and the deletion Δ117 in tcdC (Xpert® C. difficile/Epi). Recurrence was defined as a positive laboratory test result for C. difficile more than 14 days but within 8 weeks after the initial diagnosis date with reappearance of symptoms. To identify factors associated with recurrence in 027+ and 027– CDI, a multivariate analysis was performed in each patient group. Subdistributional hazard ratios (sHRs) and 95% confidence intervals (95%CIs) were calculated. Results: Overall, 238 patients with 027+ CDI and 267 with 027– CDI were analysed. On multivariate analysis metronidazole monotherapy (sHR 2.380, 95%CI 1.549–3.60, p <0.001) and immunosuppressive treatment (sHR 3.116, 95%CI 1.906–5.090, p <0.001) were factors associated with recurrence in patients with 027+ CDI. In this patient group, metronidazole monotherapy was independently associated with recurrence in both mild/moderate (sHR 1.894, 95%CI 1.051–3.410, p 0.033) and severe CDI (sHR 2.476, 95%CI 1.281–4.790, p 0.007). Conversely, non-severe disease (sHR 3.704, 95%CI 1.437–9.524, p 0.007) and absence of chronic renal failure (sHR 16.129, 95%CI 2.155–125.000, p 0.007) were associated with recurrence in 027– CDI. Conclusions: Compared to vancomycin, metronidazole monotherapy appears less effective in curing CDI without relapse in the 027+ patient group, independently of disease severity
Microbiologic characteristics and predictors of mortality in bloodstream infections in intensive care unit patients: A 1-year, large, prospective surveillance study in 5 Italian hospitals
Bloodstream infections (BSIs) from multidrug-resistant (MDR) bacteria cause morbidity and mortality in intensive care unit (ICU) patients worldwide. This study investigated the incidence of BSIs in 5 adult general ICUs in Rome, Italy, and evaluated the mortality rate and risk factors associated with these infections
Graviton Vertices and the Mapping of Anomalous Correlators to Momentum Space for a General Conformal Field Theory
We investigate the mapping of conformal correlators and of their anomalies
from configuration to momentum space for general dimensions, focusing on the
anomalous correlators , - involving the energy-momentum tensor
with a vector or a scalar operator () - and the 3-graviton vertex
. We compute the , and one-loop vertex functions in
dimensional regularization for free field theories involving conformal scalar,
fermion and vector fields. Since there are only one or two independent tensor
structures solving all the conformal Ward identities for the or
vertex functions respectively, and three independent tensor structures for the
vertex, and the coefficients of these tensors are known for free fields,
it is possible to identify the corresponding tensors in momentum space from the
computation of the correlators for free fields. This works in general
dimensions for and correlators, but only in 4 dimensions for ,
since vector fields are conformal only in . In this way the general
solution of the Ward identities including anomalous ones for these correlators
in (Euclidean) position space, found by Osborn and Petkou is mapped to the
ordinary diagrammatic one in momentum space. We give simplified expressions of
all these correlators in configuration space which are explicitly Fourier
integrable and provide a diagrammatic interpretation of all the contact terms
arising when two or more of the points coincide. We discuss how the anomalies
arise in each approach [...]Comment: 57 pages, 7 figures. Refs adde
Two loop electroweak corrections to and in the B-LSSM
The rare decays and are important to research new physics beyond standard model. In
this work, we investigate two loop electroweak corrections to and in the minimal
supersymmetric extension of the SM with local gauge symmetry (B-LSSM),
under a minimal flavor violating assumption for the soft breaking terms. In
this framework, new particles and new definition of squarks can affect the
theoretical predictions of these two processes, with respect to the MSSM.
Considering the constraints from updated experimental data, the numerical
results show that the B-LSSM can fit the experimental data for the branching
ratios of and . The
results of the rare decays also further constrain the parameter space of the
B-LSSM.Comment: 33 pages, 9 figures, Published in EPJ
Italian consensus conference on guidelines for conservative treatment on lower limb muscle injuries in athlete.
Provide the state of the art concerning (1) biology and aetiology, (2) classification, (3) clinical assessment and (4) conservative treatment of lower limb muscle injuries (MI) in athletes. Seventy international experts with different medical backgrounds participated in the consensus conference. They discussed and approved a consensus composed of four sections which are presented in these documents. This paper represents a synthesis of the consensus conference, the following four sections are discussed: (i) The biology and aetiology of MIs. A definition of MI was formulated and some key points concerning physiology and pathogenesis of MIs were discussed. (ii) The MI classification. A classification of MIs was proposed. (iii) The MI clinical assessment, in which were discussed anamnesis, inspection and clinical examination and are provided the relative guidelines. (iv) The MI conservative treatment, in which are provided the guidelines for conservative treatment based on the severity of the lesion. Furthermore, instrumental therapy and pharmacological treatment were discussed. Knowledge of the aetiology and biology of MIs is an essential prerequisite in order to plan and conduct a rehabilitation plan. Another important aspect is the use of a rational MI classification on prognostic values. We propose a classification based on radiological investigations performed by ultrasonography and MRI strongly linked to prognostic factors. Furthermore, the consensus conference results will able to provide fundamental guidelines for diagnostic and rehabilitation practice, also considering instrumental therapy and pharmacological treatment of MI. Expert opinion, level IV
- …