L’exposition et l’indissociable union du fond et de la forme

En analysant les différents niveaux sur lesquels s’inscrit la relation fond/forme dans l’exposition, l’auteur montre que cette relation est indissociable de deux autres – espace/temps et concepteur/visiteur – et met en exergue le rôle essentiel du commissaire d’exposition pour assurer la cohérence du discours proposé aux visiteurs

Pratiques interprétatives en muséologie

Nous abordons dans cet article les divers aspects du travail de conservateur de musée, qui vont de la collecte à la médiation, en y portant un éclairage nouveau dans lequel la part de subjectivité est importante. C’est cette subjectivité qui génère des démarches d’interprétation que l’on peut classer selon quatre acceptions principales ; traduire au sens linguistique, dévoiler ce qu’il y a d’obscur dans un texte, prendre en bonne ou mauvaise part, et exécuter au sens musical ou théâtral. La conclusion donne lieu à une discussion portant sur les devoirs du conservateur eu égard au fait qu’il est à la fois représentant d’une institution et interprète autant que protecteur du patrimoine, mais aussi qu’il doit assurer un équilibre entre souci d’objectivité et contrainte de subjectivité.‪This paper addresses every aspect of a museum curator’s work, from acquisition to exhibition, focusing on the fact that subjectivity takes a prominent part in them. Interpretations emerge from this subjective approach, leading to four different meanings: translation in linguistic terms, revealing the hidden part of a text, reading or misreading a sign, and rendering a musical performance. In conclusion, we discuss curators' duties as representatives of an establishment and interpreters and protectors of a heritage, even if they must simultaneously strike a balance between necessary objectivity and inescapable subjectivity.

Subcellular Localization and Partial Purification of a Glucuronyltransferase Involved in Glucuronoxylan Synthesis in Pea (Pisum sativum var. Alaska) Etiolated Epicotyls

Glucuronyltransferase is an enzyme involved in the synthesis of the hemicellulosic glucuronoxylan. It catalyses the transfer of glucuronic acid from UDP-glucuronic acid onto a xylan backbone. The activity of this enzyme has previously been studied in whole particulate membrane preparation of etiolated pea epicotyls (Waldron & Brett, 1983). It was shown that this transferase is located chiefly within the Golgi apparatus membrane (Waldron & Brett, 1987) and that the activity can be solubilized from a crude membrane fraction with the non-ionic detergent, Triton X-100 (Waldron & Brett, 1983)

Antiinflammatory and chonroprotective activity of prodelphinidins isolated from Ribes nigrum leaves

Peer reviewe

3-Methyl-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-Dioxide

peer reviewe

A sulfonylthiourea (BM 20) related to torasemide: a new loop diuretic with relative potassium-sparing properties

A series of sulphonylthioureas related to torasemide, a high ceiling loop diuretic, were synthesized and found to inhibit the Na+ 2Cl- K+ co-transporter of the thick ascending limb of the loop of Henlé. Their diuretic properties were studied (30 mg kg-1) after oral administration to rats. Lipophilic derivatives very active in-vitro, were found inactive orally and intraperitoneally in rats. The four most active compounds were examined for their dose-dependent diuresis. Three of them showed a potency, water and electrolyte excretion similar to torasemide. The fourth molecule, a sulphonylthiourea (BM 20), exhibited relative potassium-sparing properties and a minimal diuretic dose of 0.001 mg kg-1, 200 times lower than torasemide

Design, Synthesis and Biological Activity of a Series of Torasemide Derivatives, Potent Blockers of the Na+ 2cl- K+ Co-Transporter: In-Vitro Study

Pharmacomodulation of the torasemide molecule, a loop diuretic inhibiting Na+ 2Cl- K+ co-transport in the thick ascending limb of the loop of Henle has been performed in order to obtain new long-acting diuretics. The aim of this study was to decrease the metabolism of the drug and to slow down its rate of excretion by increasing its hydrophobicity. The present study describes the synthesis and the inhibitory potency of new torasemide derivatives in the bioassay system of the cortical thick ascending limb of rabbit. A correlation between the lipophilicity (log P') of these substances and their activity as inhibitors of the Na+ Cl- K+ co-transporter was observed. The present design led to compounds more active than torasemide. Structure-activity relationships permit us to propose an interaction model between torasemide derivatives and the Na+ 2Cl- K+ co-transport system of the cortical thick ascending limb