GENHYP - A FORTRAN 5 program for general linear hypothesis testing

GENHYP FORTRAN 5 program for general linear hypothesis testin

Prevention of transplant rejection can tolerance be achieved with immunosuppressive treatment?

Successful solid organ transplantation is generally attributed to the increasingly precise ability of drugs to control rejection. However, it was recently shown that a few donor haematolymphoid cells can survive for decades in recipients of successful organ allografts, a phenomenon called microchimaerism. The association for decades of haematolymphoid chimaerism with allograft tolerance in experimental transplantation suggests that immunosuppressive drugs merely create a milieu that enables an allograft and its complement of passenger leucocytes to prime the recipient for graft acceptance. Exploitation of this concept requires a fundamental shift in the classical view of passenger leucocytes only as initiators of rejection. Microchimaerism has taught us that solid organ transplantation involves the transfep-öTEwo3öTK}r organ systems to the recipient: the allograft parenchyma an-4oHg-4oonor'-4y&eWtolymphoid system in the form of donor stem cells contajfletwit|4Q(Xj pas-4MTger leucocyte compartment. Each has the potential to integral witty-4-4orrespSnping recipient system and carry out normal physiologi|:a£futy-4ijj£jvwlta5irnmunological self definition. Resistance to initial integralen r-4WMjure £als requires some form of immunosuppression, but mainterçad-4 of donor-4Rjraiine system function will depend on renewable supply of cells, v-4Jrf-4Siyi-4jj-4fvided by engrafted progenitors. Successful clinical application willctepcrrtTon the development of low morbidity methods to enhance engraftment of donor haemopoietic stem cells. Adis international Limited All rights reserved

TALES AS OLD AS TIME: THE PROGRESSION OF CLASSIC STORY THEMES FROM FAIRY TALES TO DISNEY FILMS

The purpose of this thesis is to examine the original purpose of the most familiar fairy tales based on the state of society at the time of their conception, including the stories of the Brothers Grimm, Charles Perrault, and Hans Christian Andersen. The thesis will then compare these original themes to the themes of the Disney films they inspired, taking into account the cultural and historical factors that produced the final film. In addition, the thesis will take note of the modern interpretations of both the fairy tales and the films based on the viewpoint of our current society. In addition, this thesis will include a chapter on my capstone film Fairytale, which was created in conjunction with the thesis, as a practical application of the principles discovered in my research. The thesis focuses primarily on the themes of family relationships and the roles of women as defined by each time period

How Trigonometry Can Solve a Murder

Who killed Mr. Williamson? Is Mrs. Williamson telling the truth? Or is she lying to save herself? The answer to all of those questions can be determined through the use of blood spatter that was created during the course of events that led to Mr. Williamson’s death. Specially trained analysts, known as blood spatter analysts, use mathematics equations to determine the location of individuals and objects at a crime scene during the time that the violent crime takes place. The equations that blood spatter analysts use in their calculations comes from a division on math known as trigonometry. Investigators then use those calculated locations to determine if their witnesses or suspects are telling the truth through comparison

Benchmarking Australia's Urban Tree Canopy: An i-Tree assessment, Final Report

This report aims to provide 139 Local Governments in urban and semi urban environments across Australia with an estimate of land surface cover. This study is part of the 202020 Vision, funded by Horticulture Limited Australia, in working towards a 20% increase in the level of green space in Local Government Areas (LGAs) across the country. View/download http://202020vision.com.au/media/7141/benchmarking_australias_urban_tree_canopy.pd

Measurements of the methane relaxation times for application to the infrared emission models of the upper atmospheres of outer planets and Titan

The 7.8 micrometer emission from the nu(sub 4) band of methane (CH4) is a regularly observed feature in the stratosphere of all the giant planets and Titan. On Jupiter, enhancements in this emission are associated with the infrared hot spots in the auroral zone. Attempts to model this phenomenon in particular, and to understand the role of methane in general, have been hampered in part by a lack of adequate laboratory measurements of the collisional relaxation times for the nu(sub 3) and nu(sub 4) levels over the appropriate temperature range. To provide this needed data, a series of laboratory experiments were initiated. In the experimental arrangement the nu(sub3) band of methane is pumped at 3.3 micrometers using a pulsed infrared source (Nd:YAG/dye laser system equipped with a wave-length extender). The radiative lifetime of the nu(sub 3) level (approximately 37 ms) is much shorter than the nu(sub 4) lifetime (approximately 390 ms); however, a rapid V-V energy transfer rate ensures that the nu(sub 4) level is substantially populated. The photoacoustic technique is used to acquire relaxation rate information. The experiments are performed using a low-temperature, low-pressure cell. Experimental apparatus and technique are described. In addition some of the experimental difficulties associated with making these measurements are discussed and some preliminary results are presented

Particle Impact Analysis of Bulk Powder During Pneumatic Conveyance

Fragmentation of powders during transportation is a common problem for manufacturers of food and pharmaceutical products. We illustrate that the primary cause of breakage is due to inter-particle collisions, rather than particle-wall impacts, and provide a statistical mechanics model giving the number of collisions resulting in fragmentation

Temperature-Dependent Magnetoelectric Effect from First Principles

We show that nonrelativistic exchange interactions and spin fluctuations can give rise to a linear magnetoelectric effect in collinear antiferromagnets at elevated temperatures that can exceed relativistic magnetoelectric responses by more than 1 order of magnitude. We show how symmetry arguments, ab initio methods, and Monte Carlo simulations can be combined to calculate temperature-dependent magnetoelectric susceptibilities entirely from first principles. The application of our method to Cr2O3 gives quantitative agreement with experiment.

Mite-related bacterial antigens stimulate inflammatory cells in rosacea

Background Patients with papulopustular rosacea have a higher density of Demodex folliculorum mites on their faces than normal subjects but the role, if any, of their mites in initiating inflammation is disputed. Selective antibiotics are effective in reducing the inflammatory changes of papulopustular rosacea, but their mode of action is unknown. Objectives To investigate whether a D. folliculorum-related bacterium was capable of expressing antigens that could stimulate an inflammatory immune response in patients with rosacea. Methods A bacterium (Bacillus oleronius) was isolated from a D. folliculorum mite extracted from the face of a patient with papulopustular rosacea, and was investigated further. Results This bacterium produced antigens capable of stimulating peripheral blood mononuclear cells proliferation in 16 of 22 (73%) patients with rosacea but only five of 17 (29%) control subjects (P = 0�0105). This antigenic preparation was fractionated into 70 subfractions and the proteins in each fraction were visualized by sodium dodecyl sulphate�polyacrylamide gel electrophoresis. Western blot analysis revealed the presence of two antigenic proteins of size 62 and 83 kDa in fractions when probing with sera from patients with rosacea. No immunoreactivity to these proteins was recorded when probing with sera from control patients. Two-dimensional electrophoretic separation was used to isolate these proteins and matrix-assisted laser desorption �ionization time-of-flight analysis was employed to identify the relevant peptides. The 62-kDa immunoreactive protein shared amino acid sequence homology with an enzyme involved in carbohydrate metabolism and signal transduction while the 83-kDa protein was similar to bacterial heat shock proteins. Conclusions Antigenic proteins related to a bacterium (B. oleronius), isolated from a D. folliculorum mite, have the potential to stimulate an inflammatory response in patients with papulopustular rosacea