Fighting for Your Life in America: A Study of Right to Try Laws Throughout the Country

(Excerpt) This Note argues that there should be a federal statute granting terminally ill patients access to experimental drugs, but that the Trickett Wendler Act, as written is not the proper vehicle for change. An ideal congressional “Right to Try” statute should be crafted to make experimental drugs realistically obtainable for terminally ill patients while protecting those patients and their quality of life. The Trickett Wendler Act’s weaknesses prevent it from reaching this objective because it is too deferential to already unclear state Right to Try laws. Part I explores the right to try movement generally, explaining what a “right to try” is and the obstacles currently standing in its way. Part II examines and critiques different “Right to Try” laws that have been adopted in the states. Part III proposes a model congressional “Right to Try” bill

Mapping Environmental Justice in Jacksonville

Honorable Mention Winner Environmental Center Leadership Program Project The project is a digitally interactive map of environmental justice in Jacksonville. Environmental justice looks at vulnerable communities and how they have been impacted by environmental conditions. The map is to be used as a tool to visually display where environmental justice has occurred, who is affected, and which issues have been solved. It consolidates 19 case studies gathered from lawsuits, protests, citizen complaints, cleanups, restoration projects, and more. Map components include: case study title, location, timeline, environmental justice pillar, type of issue, summary, and links to references. Each case study has a corresponding point on the map, showing where it is located. Once selected, all of the information pops up in a text box. The map shows which areas experience environmental justice and which types of issues are most prevalent. The majority of case studies gathered are located in the “Urban Core” neighborhoods and most are regarding the distribution of environmental hazards. These environmental hazards include the spread of chemicals from waste incinerators and other industrial facilities. Vulnerable groups dealing with resulting health issues are children, elderly, African Americans, low-income groups, families, and more. The map is an open-ended project and can be updated as new data and case studies become known. The map is published on BatchGeo and can be accessed at https://batchgeo.com/map/ea79b6e381fd1b28f23e92612a7e8d4

Korean Rapprochement: A Response to Changing Attitudes in a Multipolar World

Political Scienc

The human platelet: strong transcriptome correlations among individuals associate weakly with the platelet proteome.

BACKGROUND: For the anucleate platelet it has been unclear how well platelet transcriptomes correlate among different donors or across different RNA profiling platforms, and what the transcriptomes\u27 relationship is with the platelet proteome. We profiled the platelet transcriptome of 10 healthy young males (5 white and 5 black) with no notable clinical history using RNA sequencing and by Affymetrix microarray. RESULTS: We found that the abundance of platelet mRNA transcripts was highly correlated across the 10 individuals, independently of race and of the employed technology. Our RNA-seq data showed that these high inter-individual correlations extend beyond mRNAs to several categories of non-coding RNAs. Pseudogenes represented a notable exception by exhibiting a difference in expression by race. Comparison of our mRNA signatures to a publicly available quantitative platelet proteome showed that most (87.5%) identified platelet proteins had a detectable corresponding mRNA. However, a high number of mRNAs that were present in the transcriptomes of all 10 individuals had no representation in the proteome. Spearman correlations of the relative abundances for those genes represented by both an mRNA and a protein showed a weak (~0.3) connection. Further analysis of the overlapping and non-overlapping platelet mRNAs and proteins identified gene groups corresponding to distinct cellular processes. CONCLUSIONS: The results of our analyses provide novel insights for platelet biology, show only a weak connection between the platelet transcriptome and proteome, and indicate that it is feasible to assemble a platelet mRNA-ome that can serve as a reference for future platelet transcriptomic studies of human health and disease. REVIEWED BY: This article was reviewed by Dr Mikhail Dozmorov (nominated by Dr Yuri Gusev), Dr Neil Smalheiser and Dr Eugene Koonin

Estudio cualitativo del análisis crítico que realiza el estudiante acerca de la utilización del portafolio como instrumento de autoevaluación (AE)

Portfolios are used in our teachers teams because we consider it an ideal instrument for the evaluation of processes (formative assessment), and results (summative assessment). This is why, under the framework of a research on the evaluation practices at the higher level, we designed a practice project in order to investigate the benefits and difficulties arising from its use. We surveyed 62 psychopedagogy students who finished their program in 2018. The answers collected were the units of analysis of a qualitative, descriptive and cross-sectional study. The results exhibited more advantages than disadvantages, which refers to the gradual appropriation of the cognitive processes of analysis and synthesis as well as oral and written communication, linked to their academic growth at the higher level. An incipient appropriation of self-regulation strategies is also noticed.El Portafolio es usado en nuestras cátedras porque lo consideramos un instrumento ideal para la evaluación de procesos (formativa), y de resultados (sumativa). Es por eso que, en el marco de un proyecto de investigación referido a las prácticas evaluativas en el nivel superior, diseñamos un trabajo práctico con el fin de indagar en 62 estudiantes de psicopedagogía que terminaban la cursada en 2018 su opinión respecto de los beneficios y dificultades que les brinda su utilización. Las respuestas fueron las unidades de análisis de un estudio de diseño cualitativo, descriptivo y transversal. Los resultados mostraron más ventajas que desventajas, las que refieren a la paulatina apropiación de procesos cognitivos de análisis y síntesis y comunicación oral y escrita vinculados a su crecimiento académico en el nivel superior. También se advierte la incipiente apropiación de estrategias de autorregulación

The complex transcriptional landscape of the anucleate human platelet.

BACKGROUND: Human blood platelets are essential to maintaining normal hemostasis, and platelet dysfunction often causes bleeding or thrombosis. Estimates of genome-wide platelet RNA expression using microarrays have provided insights to the platelet transcriptome but were limited by the number of known transcripts. The goal of this effort was to deep-sequence RNA from leukocyte-depleted platelets to capture the complex profile of all expressed transcripts. RESULTS: From each of four healthy individuals we generated long RNA (≥40 nucleotides) profiles from total and ribosomal-RNA depleted RNA preparations, as well as short RNA (\u3c40 \u3enucleotides) profiles. Analysis of ~1 billion reads revealed that coding and non-coding platelet transcripts span a very wide dynamic range (≥16 PCR cycles beyond β-actin), a result we validated through qRT-PCR on many dozens of platelet messenger RNAs. Surprisingly, ribosomal-RNA depletion significantly and adversely affected estimates of the relative abundance of transcripts. Of the known protein-coding loci, ~9,500 are present in human platelets. We observed a strong correlation between mRNAs identified by RNA-seq and microarray for well-expressed mRNAs, but RNASeq identified many more transcripts of lower abundance and permitted discovery of novel transcripts. CONCLUSIONS: Our analyses revealed diverse classes of non-coding RNAs, including: pervasive antisense transcripts to protein-coding loci; numerous, previously unreported and abundant microRNAs; retrotransposons; and thousands of novel un-annotated long and short intronic transcripts, an intriguing finding considering the anucleate nature of platelets. The data are available through a local mirror of the UCSC genome browser and can be accessed at: http://cm.jefferson.edu/platelets_2012/

Bioprinting for osteosarcoma model: Methodological aspects and experimental applications

The study aims at using the bioprinting technique to create an in vitro 3D construct of osteosarcoma, as an alternative model for studies related to Boron Neutron Capture Therapy (BNCT)

Modeling Denitrification : Can We Report What We Don't Know?

Funding Information: This study is the products of a workshop funded by the Deutsche Forschungsgemeinschaft through the research unit DFG‐FOR 2337: Denitrification in Agricultural Soils: Integrated Control and Modelling at Various Scales (DASIM), and by the German Federal Ministry of Education and Research (BMBF) under the “Make our Planet Great Again—German Research Initiative”, Grant 306060, implemented by the German Academic Exchange Service (DAAD). This work was supported by the European Union's Horizon 2020 research and innovation programme project VERIFY (grant agreement no. 776810). We would like to thank the contribution of all workshop participants of the II. DASIM Modeler Workshop. Publisher Copyright: © 2023. The Authors.Peer reviewedPublisher PD

A case report of vibration-induced hand comorbidities in a postwoman

<p>Abstract</p> <p>Background</p> <p>Prolonged exposure to hand-transmitted vibration is associated with an increased occurrence of symptoms and signs of disorders in the vascular, neurological and osteoarticular systems of the upper limbs. However, the available epidemiological evidence is derived from studies on high vibration levels caused by vibratory tools, whereas little is known about possible upper limb disorders caused by chronic exposure to low vibration levels emitted by fixed sources.</p> <p>Case presentation</p> <p>We present the case of a postwoman who delivered mail for 15 years using a low-powered motorcycle. The woman was in good health until 2002, when she was diagnosed with bilateral Raynaud's phenomenon. In March 2003 a bilateral carpal tunnel syndrome was electromyographically diagnosed; surgical treatment was ineffective. Further examinations in 2005 highlighted the presence of chronic tendonitis (right middle finger flexor).</p> <p>Risk assessment</p> <p>From 1987, for 15 years, our patient rode her motorcycle for 4 h/day, carrying a load of 20-30 kg. For about a quarter of the time she drove over country roads. Using the information collected about the tasks carried out every day by the postwoman and some measurements performed on both handles of the motorcycle, as well as on both iron parts of the handlebars, we reconstructed the woman's previous exposure to hand-arm vibration. 8-hour energy-equivalent frequency weighted acceleration was about 2.4 m/s². The lifetime dose was 1.5 × 10⁹(m²/s⁴)hd.</p> <p>Conclusions</p> <p>The particular set of comorbidities presented by our patient suggests a common pathophysiological basis for all the diseases. Considering the level of exposure to vibrations and the lack of specific knowledge on the effects of vibration in women, we hypothesize an association between the work exposure and the onset of the diseases.</p

Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs

MicroRNAs (miRNAs) are small ∼22-nt RNAs that are important regulators of posttranscriptional gene expression. Since their initial discovery, they have been shown to be involved in many cellular processes, and their misexpression is associated with disease etiology. Currently, nearly 2,800 human miRNAs are annotated in public repositories. A key question in miRNA research is how many miRNAs are harbored by the human genome. To answer this question, we examined 1,323 short RNA sequence samples and identified 3,707 novel miRNAs, many of which are human-specific and tissue-specific. Our findings suggest that the human genome expresses a greater number of miRNAs than has previously been appreciated and that many more miRNA molecules may play key roles in disease etiology