Correlation methods for the analysis of X-ray polarimetric signals

X-ray polarimetric measurements are based on studying the distribution of the directions of scattered photons or photoelectrons and on the search of a sinusoidal modulation with a period of {\pi}. We developed two tools for investigating these angular distributions based on the correlations between counts in phase bins separated by fixed phase distances. In one case we use the correlation between data separated by half of the bin number (one period) which is expected to give a linear pattern. In the other case, the scatter plot obtained by shifting by 1/8 of the bin number (1/4 of period) transforms the sinusoid in a circular pattern whose radius is equal to the amplitude of the modulation. For unpolarized radiation these plots are reduced to a random point distribution centred at the mean count level. This new methods provide direct visual and simple statistical tools for evaluating the quality of polarization measurements and for estimating the polarization parameters. Furthermore they are useful for investigating distortions due to systematic effects

Imaging X-ray Polarimetry Explorer Mission Overview and Systems Engineering Status

The Imaging X-ray Polarimetry Explorer (IXPE) is a space-based observatory that will have the capability to measure the polarization of X-rays from astrophysical sources. IXPE will improve sensitivity over OSO-8, the only previous X-ray polarimeter, by two orders of magnitude in required exposure time. IXPE will yield insight into our understanding of X-ray production in objects such as neutron stars as well as stellar and supermassive black holes. IXPE measurements will provide new dimensions for probing a wide range of cosmic X-ray sources-including active galactic nuclei (AGN) and microquasars, pulsars and pulsar wind nebulae, magnetars, accreting X-ray binaries, supernova remnants, and the Galactic center

An evaluation of morphological and functional multi-parametric MRI sequences in classifying non-muscle and muscle invasive bladder cancer

Objectives: Our goal is to determine the ability of multi-parametric magnetic resonance imaging (mpMRI) to differentiate muscle invasive bladder cancer (MIBC) from non-muscle invasive bladder cancer (NMIBC). Methods: Patients underwent mpMRI before tumour resection. Four MRI sets, i.e. T2-weighted (T2W) + perfusion-weighted imaging (PWI), T2W plus diffusion-weighted imaging (DWI), T2W + DWI + PWI, and T2W + DWI + PWI + dif-fusion tensor imaging (DTI) were interpreted qualitatively by two radiologists, blinded to histology results. PWI, DWI and DTI were also analysed quantitatively. Accuracy was determined using histopathology as the reference standard. Results: A total of 82 tumours were analysed. Ninety-six percent of T1-labeled tumours by the T2W + DWI + PWI image set were confirmed to be NMIBC at histopathology. Overall accuracy of the complete mpMRI protocol was 94% in differentiating NMIBC from MIBC. PWI, DWI and DTI quantitative parameters were shown to be significantly different in cancerous versus non-cancerous areas within the bladder wall in T2-labelled lesions. Conclusions: MpMRI with DWI and DTI appears a reliable staging tool for bladder cancer. If our data are validated, then mpMRI could precede cystoscopic resection to allow a faster recognition of MIBC and accelerated treatment pathways. Key Points: • A critical step in BCa staging is to differentiate NMIBC from MIBC. • Morphological and functional sequences are reliable techniques in differentiating NMIBC from MIBC. • Diffusion tensor imaging could be an additional tool in BCa staging

A setup for soft proton irradiation of X-ray detectors for future astronomical space missions

Protons that are trapped in the Earth's magnetic field are one of the main threats to astronomical X-ray observatories. Soft protons, in the range from tens of keV up to a few MeV, impinging on silicon X-ray detectors can lead to a significant degradation of the detector performance. Especially in low earth orbits an enhancement of the soft proton flux has been found. A setup to irradiate detectors with soft protons has been constructed at the Van-de-Graaff accelerator of the Physikalisches Institut of the University of T\"ubingen. Key advantages are a high flux uniformity over a large area, to enable irradiations of large detectors, and a monitoring system for the applied fluence, the beam uniformity, and the spectrum, that allows testing of detector prototypes in early development phases, when readout electronics are not yet available. Two irradiation campaigns have been performed so far with this setup. The irradiated detectors are silicon drift detectors, designated for the use on-board the LOFT space mission. This paper gives a description of the experimental setup and the associated monitoring system.Comment: 20 pages, 10 figures, 4 table

Multiple endocrine neoplasia type 1

Multiple Endocrine Neoplasia type 1 (MEN1) is a rare autosomal dominant hereditary cancer syndrome presented mostly by tumours of the parathyroids, endocrine pancreas and anterior pituitary, and characterised by a very high penetrance and an equal sex distribution. It occurs in approximately one in 30,000 individuals. Two different forms, sporadic and familial, have been described. The sporadic form presents with two of the three principal MEN1-related endocrine tumours (parathyroid adenomas, entero-pancreatic tumours and pituitary tumours) within a single patient, while the familial form consists of a MEN1 case with at least one first degree relative showing one of the endocrine characterising tumours. Other endocrine and non-endocrine lesions, such as adrenal cortical tumours, carcinoids of the bronchi, gastrointestinal tract and thymus, lipomas, angiofibromas, collagenomas have been described. The responsible gene, MEN1, maps on chromosome 11q13 and encodes a 610 aminoacid nuclear protein, menin, with no sequence homology to other known human proteins. MEN1 syndrome is caused by inactivating mutations of the MEN1 tumour suppressor gene. This gene is probably involved in the regulation of several cell functions such as DNA replication and repair and transcriptional machinery. The combination of clinical and genetic investigations, together with the improving of molecular genetics knowledge of the syndrome, helps in the clinical management of patients. Treatment consists of surgery and/or drug therapy, often in association with radiotherapy or chemotherapy. Currently, DNA testing allows the early identification of germline mutations in asymptomatic gene carriers, to whom routine surveillance (regular biochemical and/or radiological screenings to detect the development of MEN1-associated tumours and lesions) is recommended

Geometrical tools for the analysis of x-ray polarimetric signals

SPIE grants to authors (and their employers) of papers, posters, and presentation recordings published in SPIE Proceedings or SPIE Journals on the SPIE Digital Library (hereinafter "publications") the right to post an author-prepared version or an official version (preferred version) of the publication on an internal or external server controlled exclusively by the author/employer or the entity funding the research, provided that (a) such posting is noncommercial in nature and the publication is made available to users without charge; (b) an appropriate copyright notice and citation appear with the publication; and (c) a link to SPIE's official online version of the publication is provided using the item's DOI. This authorization does not extend to third-party web sites not owned and maintained by the author/employer such as ResearchGate, Academia.edu, YouTube, etc.X-ray polarimetric measurements are based on the study of distributions of the directions of scattered photons or photoelectrons and the search of a sinusoidal modulation with a period of π. We present a new simple tool based on a scatter plot of the modulation curve in which the counts in each angular bin are reported after a shifting by 1/4 of the period. The sinusoidal pattern is thus transformed in a circular plot whose radius is equal to the amplitude of the modulation, while for a not polarized radiation the scatter plot is reduced to a random point distribution centred at the mean frequency value. The advantage of this tool is that one can easily evaluate the statistical significance of the polarimetric detection and can obtain useful information on the quality of the measurement