39 research outputs found
AIforCOVID: predicting the clinical outcomes in patients with COVID-19 applying AI to chest-X-rays. An Italian multicentre study
Recent epidemiological data report that worldwide more than 53 million people
have been infected by SARS-CoV-2, resulting in 1.3 million deaths. The disease
has been spreading very rapidly and few months after the identification of the
first infected, shortage of hospital resources quickly became a problem. In
this work we investigate whether chest X-ray (CXR) can be used as a possible
tool for the early identification of patients at risk of severe outcome, like
intensive care or death. CXR is a radiological technique that compared to
computed tomography (CT) it is simpler, faster, more widespread and it induces
lower radiation dose. We present a dataset including data collected from 820
patients by six Italian hospitals in spring 2020 during the first COVID-19
emergency. The dataset includes CXR images, several clinical attributes and
clinical outcomes. We investigate the potential of artificial intelligence to
predict the prognosis of such patients, distinguishing between severe and mild
cases, thus offering a baseline reference for other researchers and
practitioners. To this goal, we present three approaches that use features
extracted from CXR images, either handcrafted or automatically by convolutional
neuronal networks, which are then integrated with the clinical data. Exhaustive
evaluation shows promising performance both in 10-fold and leave-one-centre-out
cross-validation, implying that clinical data and images have the potential to
provide useful information for the management of patients and hospital
resources
Virally and physically transgenized equine adipose-derived stromal cells as a cargo for paracrine secreted factors
<p>Abstract</p> <p>Background</p> <p>Adipose-Derived Stromal Cells have been shown to have multiple lineage differentiation properties and to be suitable for tissues regeneration in many degenerative processes. Their use has been proposed for the therapy of joint diseases and tendon injuries in the horse. In the present report the genetic manipulation of Equine Adipose-Derived Stromal Cells has been investigated.</p> <p>Results</p> <p>Equine Adipose-Derived Stromal Cells were successfully virally transduced as well as transiently and stably transfected with appropriate parameters, without detrimental effect on their differentiation properties. Moreover, green fluorescent protein alone, fused to <it>neo </it>gene, or co-expressed as bi-cistronic reporter constructs, driven by viral and house-keeping gene promoters, were tested. The better expressed cassette was employed to stably transfect Adipose-Derived Stromal Cells for cell therapy purposes. Stably transfected Equine Adipose-Derived Stromal Cells with a heterologous secreted viral antigen were able to immunize horses upon injection into the lateral wall of the neck.</p> <p>Conclusion</p> <p>This study provides the methods to successfully transgenize Adipose-Derived Stromal Cells both by lentiviral vector and by transfection using optimized constructs with suitable promoters and reporter genes. In conclusion these findings provide a working platform for the delivery of potentially therapeutic proteins to the site of cells injection via transgenized Equine Adipose-Derived Stromal Cells.</p
NEMO-SN1 Abyssal Cabled Observatory in the Western Ionian Sea
The NEutrinoMediterranean Observatory—Submarine
Network 1 (NEMO-SN1) seafloor observatory is located in
the central Mediterranean Sea, Western Ionian Sea, off Eastern Sicily (Southern Italy) at 2100-m water depth, 25 km from the harbor of the city of Catania. It is a prototype of a cabled deep-sea multiparameter observatory and the first one operating with real-time data transmission in Europe since 2005. NEMO-SN1 is also the first-established node of the European Multidisciplinary Seafloor Observatory (EMSO), one of the incoming European large-scale research infrastructures included in the Roadmap of the European Strategy Forum on Research Infrastructures
(ESFRI) since 2006. EMSO will specifically address long-term
monitoring of environmental processes related to marine ecosystems, marine mammals, climate change, and geohazards
Tendiniti e desmiti: considerazioni sull’intervento di Asheim (tendon splitting).
La clinica veterinari
Impiego di chiodi riassorbibili nel trattamento di distacchi epifisari distali di femore
Valutazione retrospettiva a lungo termine dell’efficacia della stenosi lombosacrale degenerativa in 69 cani
Focal canine tetanus: Diagnostic value of electromyography
A four-year-old, male Italian hound was presented with severe spasticity of both thoracic limbs that worsened with external stimuli. The remainder of the neurological and general physical examination was normal. Complete blood cell count, chemistry profile, and serology for protozoal diseases were within normal limits. Survey radiography of the cervicothoracic spine and abdominal ultrasonography showed no abnormalities. Electromyography of the thoracic limbs demonstrated the presence of 'doublets' and simultaneous activity in both agonist and antagonist muscles. These abnormalities may be explained by a defective glycinergic inhibition at the spinal cord level. Together with the history, progression of signs, and clinical findings, electromyography supported a presumptive diagnosis of focal tetanus. The dog received tetanus antitoxin and antibiotic treatment and gradually improved over four months. © 2006 British Small Animal Veterinary Association.SCOPUS: ar.jFLWINinfo:eu-repo/semantics/publishe