Analysis of pedestrian-vehicle traffic conflicts in street designs with elements of shared space

This paper investigates changes in pedestrian-vehicle traffic conflicts in urban streets redesigned according to the principles of shared space, using a recently developed Pedestrian-Vehicle Conflicts Analysis (PVCA) method. In a first step, the PVCA method is revised to more accurately reflect the features of shared space: this includes the definition of a systematic process for identifying conflict occurrences on one hand, and the full quantification of the conflict severity grading process on the other. Then, the refined PVCA method is applied to a case study in London, using video data from periods before and after the redevelopment of the Exhibition Road site from a conventional dual carriageway to a modern design with some elements of shared space. The results of the comparative analysis carried out indicate a general decrease in traffic conflict rates as a result of the redesign, but also highlight specific issues that may require additional analysis

Cellular processes of v-Src transformation revealed by gene profiling of primary cells - Implications for human cancer

<p>Abstract</p> <p>Background</p> <p>Cell transformation by the Src tyrosine kinase is characterized by extensive changes in gene expression. In this study, we took advantage of several strains of the Rous sarcoma virus (RSV) to characterize the patterns of v-Src-dependent gene expression in two different primary cell types, namely chicken embryo fibroblasts (CEF) and chicken neuroretinal (CNR) cells. We identified a common set of v-Src regulated genes and assessed if their expression is associated with disease-free survival using several independent human tumor data sets.</p> <p>Methods</p> <p>CEF and CNR cells were infected with transforming, non-transforming, and temperature sensitive mutants of RSV to identify the patterns of gene expression in response to v-Src-transformation. Microarray analysis was used to measure changes in gene expression and to define a common set of v-Src regulated genes (CSR genes) in CEF and CNR cells. A clustering enrichment regime using the CSR genes and two independent breast tumor data-sets was used to identify a 42-gene aggressive tumor gene signature. The aggressive gene signature was tested for its prognostic value by conducting survival analyses on six additional tumor data sets.</p> <p>Results</p> <p>The analysis of CEF and CNR cells revealed that cell transformation by v-Src alters the expression of 6% of the protein coding genes of the genome. A common set of 175 v-Src regulated genes (CSR genes) was regulated in both CEF and CNR cells. Within the CSR gene set, a group of 42 v-Src inducible genes was associated with reduced disease- and metastasis-free survival in several independent patient cohorts with breast or lung cancer. Gene classes represented within this group include DNA replication, cell cycle, the DNA damage and stress responses, and blood vessel morphogenesis.</p> <p>Conclusion</p> <p>By studying the v-Src-dependent changes in gene expression in two types of primary cells, we identified a set of 42 inducible genes associated with poor prognosis in breast and lung cancer. The identification of these genes provides a set of biomarkers of aggressive tumor behavior and a framework for the study of cancer cells characterized by elevated Src kinase activity.</p

Causes of reactor shutdowns

The purpose of this report is to present an analysis of causes of reactor shutdown as a support to various engineering programs presently under study. Continuing measurement and correlation of these facts can demonstrate the incentives and the necessity for modifying or changing present concepts in reactor safety and control circuits as reactor power levels are continuously increased

Scope report Safety Circuit Trip Identification System

The purpose of this report is to establish the scope of a project to provide a system which will quickly and accurately identify the sources of all reactor scrams

Reactor instrumentation and safety circuit status review and program document

This document has been prepared for internal use by the General Electric Company to serve as a program for evaluating reactor instrumentation and safety circuit equipment needs. It is intended that this document be used as a guide for defining, planning and scheduling engineering effort; budgeting of capital money; and project planning for new instrumentation systems. Effort will be made to periodically evaluate the status of the programs presented and provide updating information accordingly.After a plant has been built and operated for a number of years, it becomes apparent to operating and engineering personnel that certain modifications in controls and monitoring systems would provide both tangible and intangible benefits. Systems which were once thought to be the primary points of control shift in importance as others become recognized. As time passes this shifting spreads the main control focus from the central control desk to various other areas in the control room. Production rate increases cause instrument ranges and scales to be changed so that information on the process can still be obtained from existing equipment. Response times, sensitivity, limits, and time constants which were figured for one level must be used or revised for new levels. Further, it is discovered that the process monitoring points could be relocated or increased in number to provide more and better data on plant operation. New monitoring equipment is developed and installed to fill voids in information so production can continue meeting high standards for safety and process control. Equipment is fitted here and there in an already crowded control room, and some is even relocated to less advantageous positions to make available the necessary panel space. This in brief, is the rather complex status of Hanford Production Reactor instrumentation today

Characteristics of youth who leave the emergency department without being seen following sports-related concussion

Aim: Despite the rising incidence of emergency department (ED) visits for sports-related concussion, the frequency and characteristics of youth leaving before being seen are unknown. Methodology: National estimates of ED visits for sports-related head injuries among youth (10–18 years) were generated for 2006–2017 using the National Electronic Injury Surveillance System. Logistic regression models estimated the odds of leaving without being seen across patient characteristics and time. Results: From 2006 to 2017, 985,966 (95% CI: 787,296–1,184,637) ED visits were identified for sports-related concussions, of which 5015 (95% CI: 3024–7006) left without being seen. Conclusion: Youth with sports-related concussion must receive timely care and ED improvements may reduce rates of leaving without being seen