Congenital Bilateral Cryptophthalmos with Orbito-Palpebral Cyst and Microphthalmos

Microphthalmia is regarded as the most common congenital malformation of the eye, second only to congenital cataract. Its association with an intraorbital cyst, however, is exceedingly rare. Cryptophthalmos represents a rare anomaly characterized by the partial or complete absence of the eyebrow, palpebral fissure, eyelashes, and conjunctiva. In this condition, the partially developed adnexa are fused to the anterior segment of the globe, leading to severe ocular defects. In this report, we present a rare case of congenital bilateral cryptophthalmos accompanied by an orbitopalpebral cyst and microphthalmos and the treatment results for the patient

Combined Branch Retinal Vein and Artery Occlusion in Toxoplasmosis with Hyperhomocysteinemia, and Mutation of Factor V Leiden

Moreover, heterozygosity of a mutation of factor V Leiden; FVL (coagulation factor V gene) was also observed in the case. The patient was diagnosed with branch retinal vein and artery occlusion with hyperhomocysteinemia and mutation of factor V Leiden. The patient was underwent intravitreal injection of bevacizum (IVB), and PRP laser due to severe retinal ischemia and extensive NVD. The patient was treated with sulfamethoxazole (800 mg), trimethoprim (160 mg), and corticosteroid (1-1.5 mg/kg/day). Vitamin B6 (100 mg/daily), acid folic (5 mg daily), and vitamin B12 (112 mg/daily) were also added to the treatment for 8 weeks. After treatment, the assessment of plasma homocysteine showed that the level of homocysteine was normal. This is the first report of combined retinal branch vein and artery occlusion in toxoplasmosis with hyperhomocysteinemia and mutation of factor V Leiden

Effective Treatment of Cervical Lymph Node Metastasis of Breast Cancer by Low Voltage High-Frequency Electrochemotherapy

Electrochemotherapy (ECT) is a new local treatment method for solid and superficial tumors. During this new technique, patients experience an unpleasant sensation and slight edema. Most unpleasant and painful is mainly attributed to muscle contractions provoked by high amplitude and low repetition frequency pulses. Recently, we showed that electrochemotherapy using low voltage and higher repetition frequency (LVHF ECT) is an effective tool for inhibiting tumor growth and inducing cell permeabilization. Low voltage high-frequency electrochemotherapy was developed and optimized in vitro and in vivo which and can be used in the clinic. In the present study, we report a case of cervical lymph node metastasis of breast cancer treated by the technique. In our case, LVHF ECT was successful in reducing the size and palliating the symptoms of cervical lymph node metastasis in clinical conditions, whereas other approaches were inefficient. Our electrochemotherapy technique shows good clinical results. However, more studies on this new method are necessary to prove that LVHF ECT can be considered as a standard treatment modality

Isolation and identification of phenol degrading bacteria from Kor river and their growth kinetics assay

Background : Phenol and it’s derivatives were removed by physicochemical methods in the past but nowadays biological treatment has priority. Bacteria with the rapid proliferation in the presence of phenol and it’s derivatives can remove them in a good manner. The aim of this project is isolation and identification of bacteria that degrade phenol from water and sediment of Kor river and also investigation of their growth kinetics in the presence of this toxic matrer. Materials and Methods: 60 samples from water and sediment of different area in Kor river were collected. Then collected samples were cultivated in the salt base phenol broth medium for isolation of phenol degrading bacteria. For screening of phenol degrading bacteria bromothymol blue was added to culture medium. Bacteria were cultivated in different concentrations of phenol (0.2-0.9 g/L), so bacterial ability in degrading of different concentrations of phenol was measured. Investigation of growth kinetics of bacteria was done by continuously recorded of optical absorption in 600 nm (OD600). In this method after primary record of OD, culture media were placed in incubator for 24 hours and in 30ºC with round of 100 rpm. After that optical absorption was recorded for 300 hours. Results: Pseudomonas sp were amongst the most important phenol degrading bacteria which were isolated from Kor river. They have a wide frequency in different area of this river. Acinetobacter also was important after Pseudomonas. The most of isolated bacteria had special ability in degrading phenol .For example Pseudomonas up to 0.9 g/L, Acinetobacter up to 0.8 g/L, Shigella, Salmonella, Klebsiella, and Citrobacter up to 0.6 g/L and other bacteria up to 0.2-0.3 g/L removed phenol from culture medium. Investigation of OD600 also confirmed acquired data because Pseudomonas had the most value of OD and maximum optical absorption for each bacterium was observed in the maximum degradation concentration. Conclusion: Kor river has many phenol degrading bacteria that have high ability in phenol degrading. Pseudomonas and Acinetobacter can be referred to as the most important ones

Positive block matrices on Hilbert and Krein C*-modules

Let H1 and H2 be Hilbert C*-modules. In this paper we give some necessary and sufficient conditions for the positivity of a block matrix on the Hilbert C*-module H1⊕H2

Accidents in children under 5 years in Yazd province, Iran

Introduction:Accidents are one of the most important causes of injury and death across the world, including Iran. The epidemiological data play a key role in taking effective strategic decisions for their prevention and control. This study was conducted to determine the Frequency of different types of accidents in children aged under 5 years living in Yazd province, Iran. Methods: In this cross-sectional study, data on 2489 children under 5 years referred to hospitals in Yazd province were collected from March, 2015 to March, 2016, using the accidents registration forms and the related software. Chi-square test was incorporated to analyze the results using SPSS version 19. Results: The frequency of accidents in boys was 1460 (58.7%) and in girls 1029 (41.3%). Accidents occurred most frequently in April-May (n: 245, 9.8%) and the winter (n: 693, 27.8%). 93.3% of accidents occurred in the urban areas, 4.4% in the rural areas and 2.3% in outside the city and the villages. The total  number of accidents at home was 1743 (70%) and in the alleys and on the streets 495 (19%), the most frequent accident was falling (n: 743, 29.9%), followed by burns (n: 543, 21.8%) and  trauma (n: 495, 19.9%). The difference in the type of accident between different age groups was significant (P< 0.001). Conclusion: The comparatively higher frequency of falling, burn, trauma, as well as the accidents at home and in the winter indicate parents’ insufficient attention to home safety standards and their lack of adequate information about protection of children under5 years against the most common accidents of this age group. Planning for and intervention in these areas might help in reducing the accidents

Sleep habits and road traffic accident risk for Iranian occupational drivers

Objectives: The aim of this study is to assess the sleep quality and sleep disorders (prevalence of obstructive sleep apnea and sleepiness) among occupational drivers in Iran and to determine which demographic factors and occupational habits are linked to road traffic accidents. Material and Methods: In this analytic cross-sectional study 556 occupational road drivers from Shahroud city (in the northeast of Iran) participated, upon a prior verbal informed consent, during 2013–2014. The Pittsburgh Sleep Quality Index (PSQI) standard questionnaire that scored on 7 point scale, the 8-item Epworth Sleepiness Scale (ESS) questionnaire and the 8-question STOP-Bang questionnaire along with demographic information and occupational data were used. To explore the independent factors associated with odds of poor sleep quality and road accident, multiple logistic regression models were used. Results: Prevalence of previous road accidents, sleepiness while driving, and obstructive sleep apnea scored ≥ 3 in the study, and drivers accounted for 23.8%, 29%, and 24.8%, respectively. The global mean score of sleep quality and excessive sleepiness score were 5.2 and 4.8, respectively. The main factors related to the odds of poor sleep quality were snoring (odds ratio (OR) = 2.34; 95% confidence interval (CI): 1.15–4.77), smoking (OR = 2.12; 95% CI: 1.15–3.97), and driving times in a day (OR = 1.12; 95% CI: 1.03–1.21). The Epworth Sleepiness Scale (OR = 1.13; 95% CI: 1.07–1.23) and suffering from apnea (OR = 4.89; 95% CI: 1.07–23.83) were the best predictors for odds (increased risk) of road accidents. Conclusions: A considerable proportion of Iranian drivers had records of road accidents; poor sleep quality, sleepiness while driving, and sleep disorder breathing (obstructive sleep apnea – OSA). Snoring, smoking, driving time in a day, excessive sleepiness, and presumably apnea increase the odds of poor sleep quality and road traffic accident for Iranian occupational drivers

Sleep habits and road traffic accident risk for Iranian occupational drivers

Objectives: The aim of this study is to assess the sleep quality and sleep disorders (prevalence of obstructive sleep apnea and sleepiness) among occupational drivers in Iran and to determine which demographic factors and occupational habits are linked to road traffic accidents. Material and Methods: In this analytic cross-sectional study 556 occupational road drivers from Shahroud city (in the northeast of Iran) participated, upon a prior verbal informed consent, during 2013–2014. The Pittsburgh Sleep Quality Index (PSQI) standard questionnaire that scored on 7 point scale, the 8-item Epworth Sleepiness Scale (ESS) questionnaire and the 8-question STOP-Bang questionnaire along with demographic information and occupational data were used. To explore the independent factors associated with odds of poor sleep quality and road accident, multiple logistic regression models were used. Results: Prevalence of previous road accidents, sleepiness while driving, and obstructive sleep apnea scored ≥ 3 in the study, and drivers accounted for 23.8%, 29%, and 24.8%, respectively. The global mean score of sleep quality and excessive sleepiness score were 5.2 and 4.8, respectively. The main factors related to the odds of poor sleep quality were snoring (odds ratio (OR) = 2.34; 95% confidence interval (CI): 1.15–4.77), smoking (OR = 2.12; 95% CI: 1.15–3.97), and driving times in a day (OR = 1.12; 95% CI: 1.03–1.21). The Epworth Sleepiness Scale (OR = 1.13; 95% CI: 1.07–1.23) and suffering from apnea (OR = 4.89; 95% CI: 1.07–23.83) were the best predictors for odds (increased risk) of road accidents. Conclusions: A considerable proportion of Iranian drivers had records of road accidents; poor sleep quality, sleepiness while driving, and sleep disorder breathing (obstructive sleep apnea – OSA). Snoring, smoking, driving time in a day, excessive sleepiness, and presumably apnea increase the odds of poor sleep quality and road traffic accident for Iranian occupational drivers

Developing a Curriculum Pattern of Professionalism for Medical Sciences Students

Introduction: Professional ethics in the medical sciences is an intellectual field of study that requires educating the medical team about the thoughts, ideas, and behaviors of ethical principles and values that are carefully evaluated until these principles and skills are institutionalized. In so doing, this study endeavored to develop a professional ethics curriculum template for medical students. Methods: This study was conducted using a combination method in the academic year 2020 in two phases like this qualitative (model design) and quantitative (model accreditation). Qualitative data analysis was performed by interviewing 17 members of experts in the field of education, research, treatment, and ethics in medical sciences and accreditation by 10 members of curriculum specialists and Medical ethics of different universities by using Delphi method who were selected by purposive sampling method through Brown and Clark analytical method using Atlas TI. Results: After summarizing the concepts and categories in the form of curriculum components (i.e., objectives, educational content, implementation or educational strategies and evaluation), a total of 150 conceptual propositions, one major category with four subcategories along with a sub-category, final analysis, and report a model of professionalism curriculum was presented for medical sciences students. Finally, the validation of the developed model was done by curriculum and medical ethics experts using Delphi method. Conclusion: The results revealed that the development of uniform and codified professional ethics training programs from upstream sources seems to be essential. It is also necessary to explain the educational content of practical and applicable professional ethics, training and continuous evaluation of the principles of professional ethics in all courses and disciplines to institutionalize the principles of professional ethics in three areas of education, research, and treatment