Measurements of SCRF cavity dynamic heat load in horizontal test system

The Horizontal Test System (HTS) at Fermilab is currently testing fully assembled, dressed superconducting radio frequency (SCRF) cavities. These cavities are cooled in a bath of superfluid helium at 1.8K. Dissipated RF power from the cavities is a dynamic heat load on the cryogenic system. The magnitude of heat flux from these cavities into the helium is also an important variable for understanding cavity performance. Methods and hardware used to measure this dynamic heat load are presented. Results are presented from several cavity tests and testing accuracy is discussed.Comment: 6 pp. Cryogenic Engineering Conference and International Cryogenic Materials Conference 28 Jun - 2 Jul 2009. Tucson, Arizon

Dynamic PID loop control

The Horizontal Test Stand (HTS) SRF Cavity and Cryomodule 1 (CM1) of eight 9-cell, 1.3GHz SRF cavities are operating at Fermilab. For the cryogenic control system, how to hold liquid level constant in the cryostat by regulation of its Joule-Thompson JT-valve is very important after cryostat cool down to 2.0 K. The 72-cell cryostat liquid level response generally takes a long time delay after regulating its JT-valve; therefore, typical PID control loop should result in some cryostat parameter oscillations. This paper presents a type of PID parameter self-optimal and Time-Delay control method used to reduce cryogenic system parameters' oscillation.Comment: 7 pp. Cryogenic Engineering Conference and International Cryogenic Materials Conference CEC-ICMC 2011, 13-17 June 2011. Spokane, Washingto

Guggulsterone-Mediated Enhancement of Radiosensitivity in Human Tumor Cell Lines

Purpose: To observe the effect of guggulsterone (GS) on the radiation response in human cancer cell lines. Materials and methods: The radiation response of cancer cells treated with GS was observed by cell survival studies, cell growth assay, NF-κB activity assay, western blotting of some key growth promoting receptors, the DNA repair protein γH2AX, and flow cytometry for DNA analyses. Results: GS inhibited radiation induced NF-κB activation and enhanced radiosensitivity in the pancreatic cell line, PC-Sw. It reduced both cell cycle movement and cell growth. GS reduced ERα protein in MCF7 cells and IGF1-Rβ protein in colon cancer cells and pancreatic cancer cells and inhibited DNA double strand break (DSB) repair following radiation. Conclusion: GS induced radiation sensitization may be due to several different mechanisms including the inhibition of NF-κB activation and reductions in IGF1-Rβ. In addition, GS induced γH2AX formation, primarily in the S-phase, indicates that DNA DSB's in the S-phase may be another reason for GS induced radiosensitivity. ERα down-regulation in response to GS suggests that it can be of potential use in the treatment of estrogen positive tumors that are resistant to tamoxifen

Fermilab SRF cryomodule operational experience

Fermi National Accelerator Laboratory is constructing an Advanced Accelerator Research and Development facility at New Muon Lab. The cryogenic infrastructure in support of the initial phase of the facility consists of two Tevatron style standalone refrigerators, cryogenic distribution system as well as an ambient temperature pumping system to achieve 2 K operations with supporting purification systems. During this phase of the project a single Type III plus 1.3 GHz cryomodule was installed, cooled and tested. Design constraints of the cryomodule required that the cryomodule individual circuits be cooled at predetermined rates. These constraints required special design solutions to achieve. This paper describes the initial cooldown and operational experience of a 1.3 GHz cryomodule using the New Muon Lab cryogenic system.Comment: 7 pp. Cryogenic Engineering Conference and International Cryogenic Materials Conference CEC-ICMC 2011 13-17 June 2011, Spokane, Washingto

Critical speed measurements in the Tevatron cold compressors

The Fermilab Tevatron cryogenic system utilizes high-speed centrifugal cold compressors, manufactured by Ishikawajima-Harima Heavy Industries Co. Ltd. (IHI), for high energy operations. Nominal operating range for these compressors is 43,000 to 85,000 rpm. Past foil bearing failures prompted investigation to determine if critical speeds for operating compressors fall within operating range. Data acquisition hardware and software settings will be discussed for measuring liftoff, first critical and second critical speeds. Several tests provided comparisons between an optical displacement probe and accelerometer measurements. Vibration data and analysis of the 20 Tevatron ring cold compressors will be presented

Measurements of SCRF cavity dynamic heat load in horizontal test system

The Horizontal Test System (HTS) at Fermilab is currently testing fully assembled, dressed superconducting radio frequency (SCRF) cavities. These cavities are cooled in a bath of superfluid helium at 1.8K. Dissipated RF power from the cavities is a dynamic heat load on the cryogenic system. The magnitude of heat flux from these cavities into the helium is also an important variable for understanding cavity performance. Methods and hardware used to measure this dynamic heat load are presented. Results are presented from several cavity tests and testing accuracy is discussed