Immunotherapy in Gynecological Malignancies

Cancer immunotherapy is one of the most upcoming treatment strategies emerging as a fascinating option in the management of advanced gynecological malignancies. The development of immune-based antitumor approaches has led to safer treatment options that give fruitful results in these malignancies. In this chapter we are focusing on immune-based treatment in the management of gynecological cancers like cervical cancer, endometrial cancer, ovarian cancer, and vaginal and vulvar cancer. We are also discussing the clinical studies that have been conducted or are currently underway which are exploring these immune strategies that are developing as a logical overture for the treatment of advanced cancers including gynecological cancers

Heisenberg Operator Approach for Spin Squeezing Dynamics

We reconsider the one-axis twisting Hamiltonian, which is commonly used for generating spin squeezing, and treat its dynamics within the Heisenberg operator approach. To this end we solve the underlying Heisenberg equations of motion perturbatively and evaluate the expectation values of the resulting time-dependent Heisenberg operators in order to determine approximately the dynamics of spin squeezing. Comparing our results with those originating from exact numerics reveals that they are more accurate than the commonly used frozen spin approximation.Comment: 16 pages, 3 figure

Sinonasal Cancers: Diagnosis and Management

Sinonasal cancers are rare tumors constitute 3% of head and neck cancers. These include malignancies of the nasal cavity and paranasal sinuses (maxillary sinus, ethmoid sinuses, frontal sinus and sphenoid sinus). Patients are often asymptomatic until late in the course of their disease. Tumors of the maxillary sinus are more common than those of the ethmoid sinus or nasal cavity. The workup for patients with suspected paranasal sinus tumors includes complete head and neck CT/MRI with contrast. FDG-PET/CT may be considered in the workup of patients with clinically apparent stage III or IV disease. The most common histology for these tumors is squamous cell carcinoma, others reported includes adenocarcinoma, esthesioneuroblastoma, minor salivary gland tumors, or sinonasal neuroendocrine carcinoma [SNEC]). Surgical resection for all T stages (except T4b, any N) followed by postoperative therapy remains a cornerstone of treatment. However, definitive RT or systemic therapy/RT is recommended for T4b, any N. Locoregional control and incidence of distant metastasis are dependent on T stage, N stage, and tumor histology

Thanatophoric dysplasia type 1 (TD1): a case report

Thanatophoric Dysplasia (TD) is a severe short-limb dwarfism syndrome that is usually lethal in the perinatal period. It is characterized by shortening of the limbs, severely small thorax, large head with a prominent forehead, macrocephaly, curved femur, and flattened vertebral bodies. Thanatophoric dysplasia is divided into 2 clinically defined subtypes: thanatophoric dysplasia type 1 & type 2 (TD1 & TD2). We report this case because of its rarity with review of literature

Large facial congenital melanocytic nevus: a case report

Congenital nevi are hyperpigmented macular lesions that are derivatives of the melanoblasts. Crude incidence estimates suggest that approximately 1 in 20 000 are born with a large CMN and 1 in 500 000 are born with a very large (giant) CMN. They occur in less than 1% of the neonates in any site of the body. The giant congenital nevus is greater than 20 cm in size, pigmented and often hairy. We report a classical case of large congenital melanocytic nevus present over face. The case report is being presented because of its rarity

Effect of drift region doping and coulmn thickness variations in a super junction power MOSFET: a 2-D simulation study

In this paper, a power SJMOSFET (Super junction MOSFET) transistor is simulated using PISCES-II, a 2-D numerical device simulator. The doping densities and device dimensions are chosen so as to simulate a typical device structure. These simulations are aimed at understanding the device physics through various electrical quantities like potential distribution, electric field distribution, and electron concentrations etc. in different regions of the device both in on/off states. The effects of doping variations in the ‘n’ and ‘p’ pillars of the SJMOSFET along with the variations in the column thickness of the device were investigated. Various results obtained reveal that device having equal doping in the n and p pillars and having equal width of these pillars gives the best results. The current density is maximum and the charge imbalance is minimum for this case, however the breakdown voltage increases when the width of the n pillar is decreased. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/2793

Recurrent secondary postpartum haemorrhage due to endometritis: requires 18 units blood transfusion

Postpartum hemorrhage (PPH) represents a serious problem for women and obstetricians. Because of its association with haemorrhagic shock and predisposition to disseminated coagulopathy, it is a leading cause of maternal deaths worldwide. Furthermore, the jeopardy of PPH is rising with the secondary form of PPH occurring between 24 hours and 6 weeks postpartum, when women are already discharged home. The causes of this pathology are severe inflammation (endometritis) inherited coagulation disorders, consumptive coagulopathy, and retained products of conceptions. Others are of rare occurrence, such as vessel subinvolution (VSI) of the placental implantation site, uterine artery pseudo aneurysm, or trauma

Nano computing revolution and future prospects

There are several ways nanocomputers might be built, using mechanical, electronic, biochemical, or quantum technology. It is unlikely that nanocomputers will be made out of semiconductor transistors (Microelectronic components that are at the core of all modern electronic devices), as they seem to perform significantly less well when shrunk to sizes under 100 nanometers.The research results summarized here also suggest that many useful, yet strikingly different solutions may exist for tolerating defects and faults within nanocomputing systems. Also included in the survey are a number of software tools useful for quantifying the reliability of nanocomputing systems in the presence of defects and faults