Molecular characterization of corneal ulcers causing Staphylococcus aureus

Background: The human eye is one of the most remarkable sensory systems. Human beings gather most of the information about the external environment through their eyes and thus rely on sight more than on any other sense, with the eye being the most sensitive organ we have. Molecular characterization of Staphylococcus aureus from the cases of corneal ulcers.Methods: A total of 300 samples of corneal ulcers collected from various ophthalmology hospitals, government hospital and clinical laboratories of different places of Maharashtra, India. The Isolates were identified based on the colony morphology and biochemical reaction. The isolates were subjected for antibiotic sensitivity test and perform its molecular characterization.Results: In present study, 39 coagulase positive Staphylococcus aureus, pathogenic bacteria isolated from corneal ulcers.Conclusions: Staphylococcus aureus is one of the most significant pathogens in bacterial keratitis. Early diagnosis and prompt treatment are needed to minimize the possibility of permanent vision loss and reduce structural damage to the cornea

Ascites, a New Cause for Bilateral Hydronephrosis: Case Report

Bilateral hydronephrosis secondary to urinary obstruction leads to a buildup of back pressure in the urinary tract and may lead to impairment of renal function. We present a case of a 57-year-old male with a history of alcoholic liver cirrhosis, who presented with tense ascites and acute renal failure. Bilateral hydronephrosis was seen on abdominal ultrasound. Multiple large-volume paracenteses resulted in resolution of hydronephrosis and prompt improvement in renal function

Diagnosis and management of skeletal fluorosis in current scenario: a case report

Skeletal fluorosis is a rare form of toxic metabolic disease of bone characterised by increased incorporation of fluoride in bone. Skeletal fluorosis generally occurs in endemic regions where there is increased ingestion of fluorine in water and or food over a long period of time. Fluorosis is a spectrum of disease ranging from dental, non-skeletal fluorosis to skeletal fluorosis. The disease is characterised by typical clinical and radiological features that raise the suspicion towards diagnosis of the disease. Radiographic features are characterized by generalised osteosclerosis and later ossification of ligaments, tendons and interosseous membranes. Skeletal fluorosis can be easily confused with other rheumatologic disorders. People exposed to large amounts of fluoride show dental changes much earlier than the skeletal effects. Management of fluorosis generally focuses on symptomatic treatment

Granulocyte Colony-Stimulating Factor Protects Mice during Respiratory Virus Infections

A burst in the production of pro-inflammatory molecules characterizes the beginning of the host response to infection. Cytokines, chemokines, and growth factors work in concert to control pathogen replication and activate innate and adaptive immune responses. Granulocyte colony-stimulating factor (G-CSF) mobilizes and activates hematopoietic cells from the bone marrow, and it has been shown to mediate the generation of effective immunity against bacterial and fungal infections. G-CSF is produced at high levels in the lungs during infection with influenza and parainfluenza viruses, but its role during these infections is unknown. Here we show that during infection of mice with a non-lethal dose of influenza or Sendai virus, G-CSF promotes the accumulation of activated Ly6G+ granulocytes that control the extent of the lung pro-inflammatory response. Remarkably, these G-CSF-mediated effects facilitate viral clearance and sustain mouse survival