2 research outputs found
Genetic Constructor: An Online DNA Design Platform
Genetic
Constructor is a cloud Computer Aided Design (CAD) application
developed to support synthetic biologists from design intent through
DNA fabrication and experiment iteration. The platform allows users
to design, manage, and navigate complex DNA constructs and libraries,
using a new visual language that focuses on functional parts abstracted
from sequence. Features like combinatorial libraries and automated
primer design allow the user to separate design from construction
by focusing on functional intent, and design constraints aid iterative
refinement of designs. A plugin architecture enables contributions
from scientists and coders to leverage existing powerful software
and connect to DNA foundries. The software is easily accessible and
platform agnostic, free for academics, and available in an open-source
community edition. Genetic Constructor seeks to democratize DNA design,
manufacture, and access to tools and services from the synthetic biology
community
SBOL: A community standard for communicating designs in synthetic biology
<p>Abstract</p>
<p>The Synthetic Biology Open Language (SBOL) is a proposed data standard for exchanging designs within the synthetic biology community. SBOL represents synthetic biology designs in a community-adopted, formalized format for exchange between software tools, research groups, and commercial service providers. The re-use of previously validated designs is critical to the evolution of synthetic biology from a research discipline to an engineering practice. As a community-driven standard, SBOL adapts as synthetic biology evolves, providing specific capabilities for different aspects of the synthetic biology workflow. The SBOL Developers Group has implemented SBOL 1.1 as an XML/RDF serialization and provides software libraries and specification documentation to help developers implement SBOL in their own software. This paper also reports on early successes, including a demonstration of the utility of SBOL for information exchange between three different tools from three academic sites.</p>
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