T-cell modulation for the treatment of chronic plaque psoriasis with efalizumab (Raptiva (TM)): Mechanisms of action

Psoriasis is a chronic, incurable, auto-immune disorder with cutaneous manifestations. New evidence on the central role of the immune system in the pathogenesis of psoriasis increasingly provides insight into pathogenic steps that can be modulated to provide disease control. Numerous biological therapies are in various stages of clinical development, with expectation of providing enhanced safety and efficacy over currently available psoriasis therapies. Efalizumab, a recombinant humanized monoclonal IgG1 antibody, is a novel targeted T-cell modulator that inhibits multiple steps in the immune cascade that result in the production and maintenance of psoriatic plaques, including initial T-cell activation and T-cell trafficking into sites of inflammation, including psoriatic skin, with subsequent reactivation in these sites. This article reviews the pharmacodynamic, pharmacokinetic and clinical effects observed during phase I, II and III efalizumab trials in patients with moderate to severe chronic plaque psoriasis. Copyright (C) 2004 S. Karger AG, Basel

USCID regional meetings -- 1989

Presented at Planning for water shortages: water reallocations and transfers drought management: proceedings from the 1989 regional meetings held on August 24-25, 1989 in Boise, Idaho and on October 19-21, 1989 in St. Louis, Missouri.Includes bibliograpA management improvement program to improve the performance of irrigated agriculture is described. The improvement process entails three general phases. Diagnostic analysis is an interdisciplinary field study to thoroughly understand the actual performance of an irrigation system. Areas of high and low performance are identified. Management planning is a process for organizational change. The process uses the information and understanding obtained from the diagnostic analysis to make important changes in physical structures and/or management procedures for improving irrigation system performance. Management performance is carrying out the management plan. Monitoring and evaluation is included to assist in management decision making and to measure the impact of the changes on system performance. The management planning is done by the key managers in an irrigated area, farmer representatives, and representatives from other involved organizations. Conscious, deliberate applications of the processes offer important advantages to the farming community and to water management professionals. The results are effective, appropriate solutions to many relevant problems in irrigation

Formation of spatially periodic fronts of high-energy electrons in a radio-frequency driven surface microdischarge

The generation of spatially periodic fronts of high-energy electrons (>13.48 eV) has been investigated in a radio-frequency surface microdischarge in atmospheric-pressure argon. Optical emission spectroscopy is used to study the Ar I 2p1−1s2 transition surrounding a filamentary microdischarge, both spatially and with respect to the phase of the applied voltage. The formation of excitation fronts, which remain at a constant propagation distance throughout the RF cycle and for the duration of the pulse, may be explained by a localized increase in the electric field at the tip of surface-charge layers that are deposited during the extension phase

Nanosecond optical imaging spectroscopy of an electrothermal radiofrequency plasma thruster plume

Nanosecond optical imaging spectroscopy is employed to investigate the spatio-temporal dynamics of the plasma plume expanding from a 4.2 mm-diameter, 20 mm-long cylindrical capacitively coupled electrothermal radiofrequency (rf) driven thruster using 10 W of power at 12.50 MHz and an argon pressure of 1.5 Torr. On-axis, the plume exhibits four distinct peaks of optical emission intensity within the rf period. The plume has a spherical shape with a transient radial extension (during half of the rf cycle) at the thruster exit plane due to an rf current to ground when the grounded electrode acts as an anode

The formation of atomic oxygen and hydrogen in atmospheric pressure plasmas containing humidity : picosecond two-photon absorption laser induced fluorescence and numerical simulations

Atmospheric pressure plasmas are effective sources for reactive species, making them applicable for industrial and biomedical applications. We quantify ground-state densities of key species, atomic oxygen (O) and hydrogen (H), produced from admixtures of water vapour (up to 0.5%) to the helium feed gas in a radio-frequency-driven plasma at atmospheric pressure. Absolute density measurements, using two-photon absorption laser induced fluorescence, require accurate effective excited state lifetimes. For atmospheric pressure plasmas, picosecond resolution is needed due to the rapid collisional de-excitation of excited states. These absolute O and H density measurements, at the nozzle of the plasma jet, are used to benchmark a plug-flow, 0D chemical kinetics model, for varying humidity content, to further investigate the main formation pathways of O and H. It is found that impurities can play a crucial role for the production of O at small molecular admixtures. Hence, for controllable reactive species production, purposely admixed molecules to the feed gas is recommended, as opposed to relying on ambient molecules. The controlled humidity content was also identified as an effective tailoring mechanism for the O/H ratio

Airborne defibrillation ... the sequel

SummaryThe greatest potential error occurring during attempted cardiac resuscitation is to delay administering the initial shock.2 Defibrillation with current equipment can be performed without hesitation whether the rotary or fixed-wing aircraft is in flight or on the ground.Despite cramped quarters and sensitive electrical equipment, defibrillation can be safely performed in all types of rotary and fixed-wing aircraft currently in use for emergency medical transports.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/29463/1/0000548.pd

Inducing locally structured ion energy distributions in intermediate-pressure plasmas

Ion energy distribution functions (IEDFs) incident upon material surfaces in radio frequency (rf) capacitively coupled plasmas are coupled to spatial and temporal sheath dynamics. Tailoring the ion energy distribution function within intermediate-pressure plasmas (133 Pa, 1 Torr), which find application in surface modification and aerospace industries, is challenging due to the collisional conditions. In this work, experimentally benchmarked 2D fluid/Monte-Carlo simulations are employed to demonstrate the production of structured IEDFs in a collisional (200 Pa 1.5 Torr argon) rf hollow cathode discharge. The formation of structures within the IEDFs is explained by an increase in the Arþ ion-neutral mean-free-path and a simultaneous decrease in the phase-averaged sheath extension as the rf voltage frequency increases over 13.56–108.48 MHz for a constant rf voltage amplitude (increasing plasma power) and gas flow rate. Two distinct transitions in the shape of the IEDF are observed at 450 V, corresponding to the formation of “mid-energy” (60–180 eV) structures between 40.68 and 54.24 MHz and additional “high energy” (180 eV) structures between 81.36 and 94.92 MHz, with the structures within each region displaying a distinct sensitivity to the applied voltage amplitude. Transitions between these energy ranges occurred at lower applied voltages for increased applied voltage frequencies, providing increased control of the mean and modal ion energy over a wider voltage range. The capabitlity to extend the range of access to an operational regime, where the structured IEDFs are observed, is desirable for applications that require control of the ion-bombardment energy under collisional plasma conditionsThe work presented herein was funded by the Engineering and Physical Sciences Research Council (EPSRC), Grant No.: EP/ m508196/1