Semantics-based information extraction for detecting economic events

As today's financial markets are sensitive to breaking news on economic events, accurate and timely automatic identification of events in news items is crucial. Unstructured news items originating from many heterogeneous sources have to be mined in order to extract knowledge useful for guiding decision making processes. Hence, we propose the Semantics-Based Pipeline for Economic Event Detection (SPEED), focusing on extracting financial events from news articles and annotating these with meta-data at a speed that enables real-time use. In our implementation, we use some components of an existing framework as well as new components, e.g., a high-performance Ontology Gazetteer, a Word Group Look-Up component, a Word Sense Disambiguator, and components for detecting economic events. Through their interaction with a domain-specific ontology, our novel, semantically enabled components constitute a feedback loop which fosters future reuse of acquired knowledge in the event detection process

Management of colorectal cancer presenting with synchronous liver metastases

Up to a fifth of patients with colorectal cancer (CRC) present with synchronous hepatic metastases. In patients with CRC who present without intestinal obstruction or perforation and in whom comprehensive whole-body imaging confirms the absence of extrahepatic disease, evidence indicates a state of equipoise between several different management pathways, none of which has demonstrated superiority. Neoadjuvant systemic chemotherapy is advocated by current guidelines, but must be integrated with surgical management in order to remove the primary tumour and liver metastatic burden. Surgery for CRC with synchronous liver metastases can take a number of forms: the 'classic' approach, involving initial colorectal resection, interval chemotherapy and liver resection as the final step; simultaneous removal of the liver and bowel tumours with neoadjuvant or adjuvant chemotherapy; or a 'liver-first' approach (before or after systemic chemotherapy) with removal of the colorectal tumour as the final procedure. In patients with rectal primary tumours, the liver-first approach can potentially avoid rectal surgery in patients with a complete response to chemoradiotherapy. We overview the importance of precise nomenclature, the influence of clinical presentation on treatment options, and the need for accurate, up-to-date surgical terminology, staging tests and contemporary management options in CRC and synchronous hepatic metastatic disease, with an emphasis on multidisciplinary care

Comparative study of different wet mineralisation digestion methods for the measurement of total mercury in biological samples

Three botanical substrates and one milkpowder were mineralised and digested by the following methods in order to measure their total mercury content: (1) HF/HNO3-KMnO4; (2) H2SO4/HNO3-KMnO4; (3) H2SO4/HNO3- H2O2; (4) H2SO4/HNO3-UV irradiation/KMnO4; (5) H2SO4/HNO3/V2O5-catalyst KMnO4 and (6) H2SO4/HNO3/V2O5-catalyst H2O2. Of these methods (1) and (5) yield similar results and produce relative standard deviation values between 0.8 and 7.6. Method (5) is the faster of the two. No interferences with the detection of Hg were observed