5 research outputs found
Amyloid peptide self assembly in protic ionic liquids
Overall, this thesis presents the novel approach of using carefully selected PILs to both control amyloid fibril formation and inhibit/dissolve Aβ fibrils through induced helical transitions. These results provide insights into future PIL-mediated protein studies and the potential application of PILs in AD pathogenesis
The impact of ionic liquids on amyloid fibrilization of AB16-22 : tuning the rate of fibrilization using a reverse Hofmeister strategy
We have shown that the amyloid fibrilization of Aß16-22 follows a reverse hofmeister trend in pILs. Fast fibrilization rates of seconds can be achieved.<br /
Role of cation in enhancing the conversion of the Alzheimer\u27s peptide into amyloid fibrils using protic ionic liquids
We report on the impact of changes in the protic ionic liquid (pIL) cation on the fibrilisation kinetics and the conversion of the A 16-22 from monomers to amyloid fibrils. When we compare the use of primary, secondary, and tertiary amines we find that the primary amine results in the greatest conversion into amyloid fibrils. We show that the pIL is directly interacting with the peptide and this likely drives the difference in conversion and kinetics observed