Infantile bullous pemphigoid: A Rare immunobullous disease where tzanck test is a valuable diagnostic aid

Abstract not available BSMMU J 2022; 15(1): 57-6

Prolidase activity in adult bipolar disorder patient: a case - control study

Background: Bipolar disorder is one of the major neuropsychiatric illnesses. It is responsible for 6.8% of disability-adjusted life years among all mental disorders. Few studies have evaluated the biochemical basis of bipolar disorder. Prolidase is an enzyme that degrade extracellular matrix into proline. In stress condition, prolidase by releasing proline maintain ATP generation, redox state, apoptosis and cell proliferation. The relationship between serum prolidase with bipolar disorder was investigated in this study. Method: A case - control study was conducted at the Department of Laboratory Medicine in collaboration with the Department of Psychiatry of Bangabandhu Sheikh Mujib Medical University, Dhaka from March 2021 to February 2022. Thirty-five patients with bipolar disorder type I consisting of 15 euthymic and 20 manic patients were enrolled in the study according to the availability of patients as cases. Thirty-five age - and sex-matched healthy individuals were recruited from the Department of Laboratory Medicine as controls. Serum prolidase level was measured in cases and controls using venous blood. Result: Serum prolidase level was significantly higher in cases than controls (P=0.021). There was no significant differences between euthymic and manic patients (P=0.629). Significant positive correlation was found between Young Mania Rating Scale severity score and serum prolidase level (P=0.001). Conclusion: Serum prolidase activity may be associated with bipolar disorder. This needs further corroboration because our sample size was small. Bangabandhu Sheikh Mujib Medical University Journal 2023;16(2): 96-100

Comparison of serum homocysteine level in young and middle-aged adult patients with coronary artery disease

Deaths due to coronary artery disease have been increasing in young people aged 15 mmol/L) was 16.2% in Group I compared to 12.4% in Group II (P=0.001). Therefore, control measures for keeping homocysteine levels within the normal range in young people might be useful. BSMMU J 2022; 15(3): 197-20

Role of Serum Ck-18 Fragment, Alanine Transaminase and Aspertate Transaminase Level in the Assessment of Fatty Liver Diseases MD. SAIFUL ISLAM SHEULY FERDOUSHI SHAHINUL ALAM TUHIN SULTANARole of Serum Ck-18 Fragment, Alanine Transaminase and Aspertate Tra

Abstract: Backgroun

Comparison of serum homocysteine level in young and middle-aged adult patients with coronary artery disease: Homocysteine in coronary artery disease

Deaths due to coronary artery disease have been increasing in young people aged <40. Studies have reported an association between these deaths with hyperhomocysteinemia. The aim of this study was to compare serum homocysteine levels in middle-aged patients with coronary artery disease. This cross-sectional study was conducted among 52 cardiology inpatients of Bangabandhu Sheikh Mujib Medical University, Dhaka, from March 2021 to February 2022. Among them, 26 were young adults (<40 years, Group I), and 26 were middle-aged (≥40 years, Group II). Serum homocysteine was measured in all of them using an automated immunoassay analyzer. The younger patients had higher (P=0.001) median homocysteine (interquartile range) level, 13.5 (7.7 –28.4 mmol/L) compared to the middle-aged group, 10.0 (5.9 – 38.5 mmol/L). The hyperhomocysteinemia (>15 mmol/L) was 16.2% in Group I compared to 12.4% in Group II (P=0.001). Therefore, control measures for keeping homocysteine levels within the normal range in young people might be useful. BSMMU J 2022; 15(3): 197-20