Association between <i>M. tuberculosis</i> lineage and disease presentation in Alberta, 1991 to mid-2007.

<p>Abbreviations: OR, odds ratio; aOR, adjusted odds ratio; CI, confidence interval; INH, isoniazid; RMP, rifampin; PZA, pyrazinamide; EMB, ethambutol; STM, streptomycin; MDR-TB, multidrug-resistant TB.</p>*<p>Non-Beijing strains are the reference group; –, logistic regression could not be completed due to cell count(s) of zero.</p>†<p>Association between Beijing lineage and each disease presentation after adjusting for sex, age, and population group; non-Beijing strains are the reference group.</p>‡<p>There were 1301 respiratory TB cases with data related to airway secretions, 1057 (81.2%) and 244 (18.8%) being attributed to non-Beijing and Beijing lineages, respectively.</p>§<p>There were 321 respiratory TB cases diagnosed after 1992 that had sputum smear-positive specimens collected on or before the date of diagnosis.</p>**<p>p = 0.053.</p>††<p>p = 0.046.</p>‡‡<p>p = 0.049.</p

Association between <i>M. tuberculosis</i> lineage and disease presentation based on age at diagnosis.

<p>Abbreviations: aOR, adjusted odds ratio, CI, confidence interval; TB, tuberculosis; MDR-TB, multidrug-resistant tuberculosis; –unable to calculate.</p>*<p>Independent of sex and origin; non-Beijing strains are the reference group.</p>†<p>Of respiratory cases, 371 cases among those aged <35 years and 929 cases among those aged ≤35 years had smear microscopy data.</p>‡<p>p = 0.042.</p>§<p>There were 76 respiratory TB cases diagnosed after 1992 that had sputum smear positive specimens collected on or before the date of diagnosis among those born in the Western Pacific and 245 cases among those born elsewhere.</p>∥<p>p = 0.072.</p

Annual incidence rates of Beijing and non-Beijing lineage strains by population group.

<p>In each panel: rates are per 100,000 person-years (y-axis); time corresponds to the year of diagnosis (x-axis); bars with dark grey shading are cases with Beijing strains; and bars with light grey shading are cases with non-Beijing strains. The panels represent total cases (panel A) as well as cases within the foreign-born Western Pacific (panel B), foreign-born ‘other’ (panel C) and Canadian-born (panel D) populations.</p