Association of processed meat and risk of colorectal cancer by genotype strata for rs4143094.

<p>*Minimal adjusted models included age, sex, study site, energy and PCs.</p><p>**Multivariable adjusted models additionally included: BMI, smoking, alcohol and other dietary factors.</p><p>Multivariable-adjusted analysis is limited to samples with available data for all covariates used in the analysis.</p

Top three SNPs according to lowest p-value for interactions with processed meat for risk of colorectal cancer using conventional case-control logistic regression approach.

<p>* CAF, count allele frequency. Count (or tested) allele is defined as the allele that was coded as 1 in the logistic regression (the other allele was coded as 0).</p><p>** interaction OR for each copy of the count allele and for each increasing quartile of processed meat intake.</p

Regional association results for the interaction between processed meat and rs4143094 with surrounding SNPs.

<p>The top half of the figure has physical position along the x-axis, and the −log10 of the meta-analysis p-value of the interaction term on the y-axis. Each dot on the plot represents the p-value of the interaction for one SNPxD in relation to colorectal cancer conducted across all studies. The most significant SNP in the region (index SNP) is marked as a purple diamond. The color scheme represents the pairwise correlation (r²) for the SNPs across the region with the index SNP. Correlation was calculated using the HapMap CEU data. The bottom half of the figure shows the position of the genes across the region. These regional association plots are also known as LocusZoom plots.</p

Associations between red and processed meat, vegetable, fruit and fiber intake and colorectal cancer risk.

<p>Odds ratios (ORs) per quartile of increasing intake, lowest quartile = reference group, N = total number of subjects, case = number of cases.</p

Forest plot for meta-analysis of interaction analysis for rs4143094 and processed meat.

<p>Odds ratios (ORs) and 95% confidence intervals (95% CI) are presented for each additional copy of the count (or tested) allele (T) and for each increasing quartile of processed meat intake in the multiplicative interaction model. The box sizes are proportional in size to the inverse of the variance for each study, and the lines visually depict the confidence interval. Results from the fixed-effects meta-analysis are shown as diamonds. The width of the diamond represents the confidence interval.</p