Detection of 2.2-3.5 Terahertz Radiation Using a Quasi-Optically Mounted Planar Schottky Diode

Practical supra-terahertz (1–5 THz) heterodyne radiometry systems require compact local oscillator and mixer components, which are suitable for robust waveguide integration. We demonstrate detection of radiation emitted by quantum cascade lasers at frequencies between 2.2 and 3.5 THz using room-temperature quasi-optically mounted planar Schottky diodes. These diodes are more readily integrated into waveguides than point-contact diodes, do not require the cryogenic environment of hot-electron bolometers and offer potentially better noise performance than superlattice devices

Towards Terawatt-Scale Spectrally Tunable Terahertz Pulses via Relativistic Laser-Foil Interactions

An ever-increasing number of strong-field applications, such as ultrafast coherent control over matter and light, require driver light pulses that are both high power and spectrally tunable. The realization of such a source in the terahertz (THz) band has long been a formidable challenge. Here, we demonstrate, via experiment and theory, efficient production of terawatt (TW)-level THz pulses from high-intensity picosecond laser irradiation on a metal foil. It is shown that the THz spectrum can be manipulated effectively by tuning the laser pulse duration or target size. A general analytical framework for THz generation is developed, involving both the high-current electron emission and a time-varying electron sheath at the target rear, and the spectral tunability is found to stem from the change of the dominant THz generation mechanism. In addition to being an ultrabright source (brightness temperature of about 1021 K) for extreme THz science, the THz radiation presented here also enables a unique in situ laser-plasma diagnostic. Employing the THz radiation to quantify the escaping electrons and the transient sheath shows good agreement with experimental measurements

Multimillijoule coherent terahertz bursts from picosecond laser-irradiated metal foils

Ultrahigh-power terahertz (THz) radiation sources are essential for many applications, for example, THz-wave-based compact accelerators and THz control over matter. However, to date none of the THz sources reported, whether based upon large-scale accelerators or high-power lasers, have produced THz pulses with energies above the millijoule (mJ) level. Here, we report a substantial increase in THz pulse energy, as high as tens of mJ, generated by a high-intensity, picosecond laser pulse irradiating a metal foil. A further up-scaling of THz energy by a factor of ∼4 is observed when introducing preplasmas at the target-rear side. Experimental measurements and theoretical models identify the dominant THz generation mechanism to be coherent transition radiation, induced by the laser-accelerated energetic electron bunch escaping the target. Observation of THz-field-induced carrier multiplication in high-resistivity silicon is presented as a proof-of-concept application demonstration. Such an extremely high THz energy not only triggers various nonlinear dynamics in matter, but also opens up the research era of relativistic THz optics

The 2023 terahertz science and technology roadmap

Terahertz (THz) radiation encompasses a wide spectral range within the electromagnetic spectrum that extends from microwaves to the far infrared (100 GHz-∼30 THz). Within its frequency boundaries exist a broad variety of scientific disciplines that have presented, and continue to present, technical challenges to researchers. During the past 50 years, for instance, the demands of the scientific community have substantially evolved and with a need for advanced instrumentation to support radio astronomy, Earth observation, weather forecasting, security imaging, telecommunications, non-destructive device testing and much more. Furthermore, applications have required an emergence of technology from the laboratory environment to production-scale supply and in-the-field deployments ranging from harsh ground-based locations to deep space. In addressing these requirements, the research and development community has advanced related technology and bridged the transition between electronics and photonics that high frequency operation demands. The multidisciplinary nature of THz work was our stimulus for creating the 2017 THz Science and Technology Roadmap (Dhillon et al 2017 J. Phys. D: Appl. Phys. 50 043001). As one might envisage, though, there remains much to explore both scientifically and technically and the field has continued to develop and expand rapidly. It is timely, therefore, to revise our previous roadmap and in this 2023 version we both provide an update on key developments in established technical areas that have important scientific and public benefit, and highlight new and emerging areas that show particular promise. The developments that we describe thus span from fundamental scientific research, such as THz astronomy and the emergent area of THz quantum optics, to highly applied and commercially and societally impactful subjects that include 6G THz communications, medical imaging, and climate monitoring and prediction. Our Roadmap vision draws upon the expertise and perspective of multiple international specialists that together provide an overview of past developments and the likely challenges facing the field of THz science and technology in future decades. The document is written in a form that is accessible to policy makers who wish to gain an overview of the current state of the THz art, and for the non-specialist and curious who wish to understand available technology and challenges. A such, our experts deliver a ‘snapshot’ introduction to the current status of the field and provide suggestions for exciting future technical development directions. Ultimately, we intend the Roadmap to portray the advantages and benefits of the THz domain and to stimulate further exploration of the field in support of scientific research and commercial realisation

The 2023 terahertz science and technology roadmap

Terahertz (THz) radiation encompasses a wide spectral range within the electromagnetic spectrum that extends from microwaves to the far infrared (100 GHz–∼30 THz). Within its frequency boundaries exist a broad variety of scientific disciplines that have presented, and continue to present, technical challenges to researchers. During the past 50 years, for instance, the demands of the scientific community have substantially evolved and with a need for advanced instrumentation to support radio astronomy, Earth observation, weather forecasting, security imaging, telecommunications, non-destructive device testing and much more. Furthermore, applications have required an emergence of technology from the laboratory environment to production-scale supply and in-the-field deployments ranging from harsh ground-based locations to deep space. In addressing these requirements, the research and development community has advanced related technology and bridged the transition between electronics and photonics that high frequency operation demands. The multidisciplinary nature of THz work was our stimulus for creating the 2017 THz Science and Technology Roadmap (Dhillon et al 2017 J. Phys. D: Appl. Phys. 50 043001). As one might envisage, though, there remains much to explore both scientifically and technically and the field has continued to develop and expand rapidly. It is timely, therefore, to revise our previous roadmap and in this 2023 version we both provide an update on key developments in established technical areas that have important scientific and public benefit, and highlight new and emerging areas that show particular promise. The developments that we describe thus span from fundamental scientific research, such as THz astronomy and the emergent area of THz quantum optics, to highly applied and commercially and societally impactful subjects that include 6G THz communications, medical imaging, and climate monitoring and prediction. Our Roadmap vision draws upon the expertise and perspective of multiple international specialists that together provide an overview of past developments and the likely challenges facing the field of THz science and technology in future decades. The document is written in a form that is accessible to policy makers who wish to gain an overview of the current state of the THz art, and for the non-specialist and curious who wish to understand available technology and challenges. A such, our experts deliver a 'snapshot' introduction to the current status of the field and provide suggestions for exciting future technical development directions. Ultimately, we intend the Roadmap to portray the advantages and benefits of the THz domain and to stimulate further exploration of the field in support of scientific research and commercial realisation

Characterisation of innate immune responses in children with Down syndrome

Introduction: Down syndrome (DS) is associated with increased incidence of infections in childhood, higher mortality from sepsis, and other inflammatory conditions such as arthropathy, thyroid and coeliac disease. Several immunodeficiencies have already been described in DS, however we evaluated novel aspects of their immune system; neutrophil and monocyte function, genes involved in Toll like receptor (TLR) pathway signalling, a broad panel of pro-and anti-inflammatory cytokines, and characterisation of the NLRP3 inflammasome. Furthermore, the clinical significance of immune screening and the latest evidence around vaccination in DS was evaluated. Methods: Children with DS and age matched controls were recruited to examine neutrophil and monocyte cell surface markers CD11b, TLR2 and TLR4 by flow cytometry. Enzyme linked immunosorbent assay (ELISA) was utilised to evaluate an extensive panel of inflammatory cytokines, and quantitative polymerase chain reaction (qPCR) to quantify fold change in expression of key genes involved in TLR signalling and the inflammasome. All experiments featured immunomodulation with pro- (LPS, Pam3Csk4) and anti-inflammatory (Melatonin, Sparstolonin B (SsnB)) stimuli. Results: Children with DS displayed further dysregulation of their immune system and inflammatory response: neutrophil endotoxin hyperresponsiveness, increased TLR2 expression on neutrophils and monocytes with abnormal TLR signalling; and further evidence of excess circulating inflammatory cytokines. Melatonin and SsnB were effective at abrogating the inflammatory response. Both the white cell (WCC) and neutrophil count were associated with poor respiratory outcome. Children with DS are at increased risk from vaccine preventable diseases like, respiratory syncytial virus (RSV), influenza, and pneumococcus. Conclusion: Children with DS have a complex and profound immune dysregulation which contributes to respiratory morbidity, mortality from sepsis and autoimmunity. Melatonin and SsnB may have potential therapeutic benefit as immunomodulators. The WCC and neutrophils may be used as biomarkers to help predict prognosis and allow timely intervention for high risk individuals. Tailored vaccination programmes should be endorsed and administered for all children with DS

Altered endotoxin responsiveness in healthy children with Down syndrome

Abstract Background Down syndrome (DS) is the most common syndromic immunodeficiency with an increased risk of infection, mortality from sepsis, and autoinflammation. Innate immune function is altered in DS and therefore we examined responses in CD11b and Toll like receptor 4 (TLR-4), which are important immune cell surface markers upregulated in response to Lipopolysaccharide (LPS) endotoxin, and the immunomodulator melatonin. Neutrophil and monocyte responses to LPS and melatonin in children with Down syndrome (DS) who were clinically stable were compared to age-matched controls. Whole blood was incubated with LPS and melatonin and the relative expression of CD11b and TLR-4 evaluated by flow cytometry. Results Children with DS had an increased response to LPS in neutrophils and intermediate monocytes, while also having elevated TLR-4 expression on non-classical monocytes compared to controls at baseline. Melatonin reduced CD11b expression on neutrophils, total monocytes, both classical and intermediate sub-types, in children with DS and controls. Conclusion Melatonin could represent a useful clinical adjunct in the treatment of sepsis as an immunomodulator. Children with DS had increased LPS responses which may contribute to the more adverse outcomes seen in sepsis

Innate immune dysregulation in multisystem inflammatory syndrome in children (MIS-C)

Abstract MIS-C is a systemic inflammation disorder with poorly characterised immunopathological mechanisms. We compared changes in the systemic immune response in children with MIS-C (n = 12, 5–13 years) to healthy controls (n = 14, 5–15 years). Analysis was done in whole blood treated with LPS. Expression of CD11b and Toll-like receptor-4 (TLR4) in neutrophils and monocytes were analysed by flow cytometry. Serum cytokines (IL-1β, IL-2, IL-6, IL-8, IL-10, IL-Ira, TNF-α, TNF-β, IFN-Υ, VEGF, EPO and GM-CSF) and mRNA levels of inflammasome molecules (NLRP3, ASC and IL-1β) were evaluated. Subpopulations of lymphocytes (CD3+, CD19+, CD56+, CD4+, CD8+, TCR Vδ1+, TCR Vδ2+) were assessed at basal levels. Absolute counts of neutrophils and NLR were high in children with MIS-C while absolute counts of lymphocytes were low. Children with MIS-C had increased levels of IL-6, IL-10, TNF-β and VEGF serum cytokines at the basal level, and significantly increased TNF-β post-LPS, compared to controls. IL-1RA and EPO decreased at baseline and post-LPS in MIS-C patients compared to controls. The percentage of CD3+ cells, NK cells and Vδ1 was lower while B cells were higher in children with MIS-C than in controls. Dysregulated immune response in children with MIS-C was evident and may be amenable to immunomodulation