MKP1 mediates resistance to therapy in HER2-positive breast tumors.

Mitogen-activated protein kinase phosphatase 1 (MKP1 or DUSP1) is an antiapoptotic phosphatase that is overexpressed in many cancers, including breast cancer. MKP1 expression is inducible in radiation-treated breast cancer cells, and correlates with human epidermal growth factor receptor 2 (ERBB2, HER2) expression. The role of MKP1 in therapy resistance suggests that targeting MKP1 in HER2-positive breast tumors may significantly enhance the efficacy of anti-HER2 and other anticancer therapies

Migration from Turkey and the Uncertainty of the Accession of Turkey to the EU

There is a fear that, if Turkey were given admission to the EU, massive migration to the other member countries of the EU would result. This paper develops a theoretical framework for the migration decision that takes into consideration the impact on uncertainty of some of the important economic and social variables that are addressed by the EU membership and institutions. It emphasizes future expectations of living conditions and the level of uncertainty associated with them as a key variable in making migration decisions. It suggests that the more prosperous and stable Turkey is expected to be in the future, the less likely a person will now want to migrate. Hence, the greater certainty now that Turkey will gain admission in to EU, the more attractive is it for potential migrants to remain in Turkey. This framework suggests that measures to hinder Turkey's entry into the EU by having national referendums to approve its entry will increase the uncertainty of the future economic and social prospects in Turkey and will encourage migrants to migrate now to the member countries of the EU.Turkey, Migration, Uncertainty, Accession, European Union

Brain Drain from Turkey: Return Intentions of Skilled Migrants

The study estimates an empirical model of return intentions using a dataset compiled from an internet survey of Turkish professionals residing abroad. In the migration literature, wage differentials are often cited as an important factor explaining skilled migration. The findings of our study suggest, however, that non-pecuniary factors, such as the importance of family and social considerations, are also influential in the return or non-return decision of the highly educated. In addition, economic instability in Turkey, prior intentions to stay abroad and work experience in Turkey also increase non-return. Female respondents also appear less likely to return indicating a more selective migration process for females.Skilled migration, Brain drain, Return intentions, Turkey

The Determinants of Return Intentions of Turkish Students and Professionals Residing Abroad: An Empirical Investigation

The study estimates an empirical model of return intentions using a dataset compiled from an internet survey of Turkish professionals and Turkish students residing abroad. In the migration literature, wage differentials are often cited as an important factor explaining skilled migration. The findings of the study suggest, however, that other factors are also important in explaining the non-return of Turkish professionals. Economic instability in Turkey is found to be an important push factor, while work experience in Turkey also increases non-return. In the student sample, higher salaries offered in the host country and lifestyle preferences, including a more organized environment in the host country, increase the probability of not-returning. For both groups, the analysis also points to the importance of prior intentions and the role of the family in the decision to return to Turkey or stay overseas.Skilled migration, brain drain, return intentions, higher education, Turkey

Brain Drain From Turkey: An Investigation of Students’ Return Intentions

The emigration of skilled individuals from Turkey attracted greater media attention and the interest of policymakers in Turkey, particularly after the experience of recurrent economic crises that have led to an increase in unemployment among the highly educated young. This study estimates a model of return intentions using a dataset compiled from an Internet survey of Turkish students residing abroad. The findings of this study indicate that, as expected, higher salaries offered in the host country and lifestyle preferences, including a more organized environment in the host country, increase the probability of student non-return. However, the analysis also points to the importance of prior return intentions and the role of the family in the decision to return to Turkey or stay overseas. It is also found that the compulsory service requirement attached to government scholarships increases the probability of student return. Turkish Student Association membership also increases return intentions. Longer stay durations, on the other hand, decrease the probability of return. These findings have important policy implications.Student non-return, brain drain, return intentions, Turkey

Brain Drain from Turkey: The Case of Professionals Abroad

The paper presents research findings on the return intentions of Turkish professionals residing abroad. The study uses a descriptive framework to establish the validity of several proposed models of non-return. The results are based on an internet survey of Turkish professionals abroad. Correspondence analysis is used to examine the relationship between return intentions and various factors that may affect this intention. The results emphasize the importance of student non-return versus traditional brain and appear to complement the various theories of student non-return. The respondents appear to come from relatively well-to-do families with highly educated parents. Many have earned their degrees from universities that have foreign language instruction. The recent economic crises in Turkey have negatively affected return intentions. We verify that return intentions are indeed linked closely with initial return plans, and that this relationship weakens with stay duration. Specialized study and work experience in the host country also all appear to contribute to explaining the incidence of non-return. Return intentions are weaker for those working in an academic environment. These results lead to important policy implications, some of which include the training of individuals for academic positions at domestic institutions, supporting study abroad for shorter periods and improving academic facilities in Turkey’s newly established universities. The government may support public and private R&D centers to increase the employability of returnees, but also to improve the quality of the higher education system in order to both reduce the need for education abroad and to increase the attractiveness of universities as prospective employment places for those acquiring education and experience abroad.skilled migration, brain drain, return migration, return intentions, higher education, Turkey

Return Intentions of University-educated Turkish Expatriates

The aim of this article is to provide new evidence on the characteristics of Turkish professionals residing overseas and the factors that are important in their decision to return home or work abroad. With this aim, we present the results of a survey conducted in 2002, which deals with the return intentions of university-educated Turkish professionals residing abroad. The article thus presents information that will be useful to policymakers in Turkey and other developing countries with similar experiences. The findings indicate that many of the university-educated expatriates are those who stayed abroad to work after completing their studies, rather than professionals with work experience in Turkey.Skilled migration, brain drain, return intentions, higher education, Turkey