QTc interval (cardiac repolarization): lengthening after meals.

Weight reduction, either by dietary or surgical means, is associated with prolongation of the heart rate corrected QT interval (QTc = QT/R-R0.5) and, on occasion, sudden death. Screening subjects with obesity before weight loss for prolonged QTc intervals is an accepted practice, although at present, there are no guidelines for whether subjects should be fasting before electrocardiogram (EKG) evaluation

Effect of variable carbohydrate intake on exercise performance in female endurance cyclists

Etude sur onze femmes pour mesurer les effets d'une prise variable d'hydrate de carbone sur le délai à l'épuisement, les variations de la fréquence cardiaque, le ratio d'échange respiratoire et l'indice de perception de l'effort

Increased sympathetic and decreased parasympathetic cardiovascular modulation in normal humans with acute sleep deprivation

Cardiovascular autonomic modulation during 36 h of total sleep deprivation (SD) was assessed in 18 normal subjects (16 men, 2 women, 26.0 ± 4.6 yr old). ECG and continuous blood pressure (BP) from radial artery tonometry were obtained at 2100 on the first study night (baseline) and every subsequent 12 h of SD. Each measurement period included resting supine, seated, and seated performing computerized tasks and measured vigilance and executive function. Subjects were not supine in the periods between measurements. Spectral analysis of heart rate variability (HRV) and BP variability (BPV) was computed for cardiac parasympathetic modulation [high-frequency power (HF)], sympathetic modulation [low-frequency power (LF)], sympathovagal balance (LF/HF power of R-R variability), and BPV sympathetic modulation (at LF). All spectral data were expressed in normalized units [(total power of the components/total power-very LF) × 100]. Spontaneous baroreflex sensitivity (BRS), based on systolic BP and pulse interval powers, was also measured. Supine and sitting, BPV LF was significantly increased from baseline at 12, 24, and 36 h of SD. Sitting, HRV LF was increased at 12 and 24 h of SD, HRV HF was decreased at 12 h SD, and HRV LF/HF power of R-R variability was increased at 12 h of SD. BRS was decreased at 24 h of SD supine and seated. During the simple reaction time task (vigilance testing), the significantly increased sympathetic and decreased parasympathetic cardiac modulation and BRS extended through 36 h of SD. In summary, acute SD was associated with increased sympathetic and decreased parasympathetic cardiovascular modulation and decreased BRS, most consistently in the seated position and during simple reaction-time testing

Method and device for high sensitivity and quantitative detection of chemical/biological molecules

A sensor for detecting the presence of predetermined chemical/biological molecules, the sensor having a MOSFET device (2,3,6,7,9,10,12,13), the gate having an array of nanoscale fingers (6,7), and on fingers or in spaces between the fingers, chemical/biological receptor molecules (15) suitable for selectively binding with the predetermined chemical/biological molecules, the sensor also having circuitry (4,5,11,12 ) for measuring a change in a change in drain current of the FET caused by the predetermined chemical/biological molecules becoming bound to the receptor molecules. Sensitivity and reliability can be increased compared to capacitive sensors