Two Students Affairs Professionals\u27 Journeys to (Un)Cover

An African-American student named Jamal adopts the nickname “Jay” when he runs for the student government association. A transgender sophomore dresses impeccably in suits and ties, even for biology lab. Yoshino (2006) described these actions as covering, where an individual masks one’s own recognized marginalized identity in order to gain acceptance within the dominant identity. The authors— a gay African-American and a heterosexual Latino— are both male student affairs professionals at predominately White institutions (PWIs). They will each look at the subtle and covert ways student affairs professionals reproduce pressures to cover and offer ways to understand the impact of conforming to the majority culture

Campus Climate Perceptions of Queer College Students of Color: Disidentifying the Rainbow

This dissertation explored the experience lesbian, gay, bisexual and queer students of col-or. Influenced by the Queer of Color theoretical framework, this dissertation employed multiple methodological traditions (namely qualitative and Scholarly Personal Narrative), to deepen the exploration and unlock multiple dimensions of experience of queer college students of color. Analysis of the student interviews produced 29 themes. The results are, framed by four categories of campus climate (behavioral, socio-historical, psychological, and structural or compo-sitional (Hurtado, Milem, Clayton-Pedersen, & Allen, 1998).), and offer a glimpse into the inter-locking dynamics of racism and homophobia that the queer students of color navigate in their efforts to make meaning of their identities as queer people of color. Reviewing the results of this study college faculty, staff, and administrators can begin to understand the unique experiences of queer college students of color. This dissertation also may contribute to theory and practice around appropriate and accurate ways to deal with complexity when measuring the campus climate for diversity

Stewardship of Underrepresented Communities

Alumni can play an important role in supporting diversity and diverse populations on campus, yet underrepresented communities such as women, people of color, and lesbian, gay, bisexual, and transgender (LGBT) alumni have been largely untapped by alumni and development offices. Proper training, sustained commitment, and culturally-specific targeted stewardship cannot only be financially rewarding, but can also work to combat myths, stereotypes and prejudice. This article will discuss the challenges and benefits involved in using stewardship to target these communities, followed by recommendations for practice and areas of further research

Bursting the Bubble: How Time-Off Student Reintegrate into the College Campus Community

Every year the incoming student body includes those returning from time-off, or a leave of absence, lasting from semesters to years. How did their time away from the classroom affect their return? How will this time away affect the rest of their college career? What were the causes of their time-off? How did they decide when to return? What immediate issues did they face upon their return? The author will explore the experience of returning students, suggesting tips for student affairs professionals to help students incorporate their experience away from school into their learning and development in college

Synthetic studies on the cyclodepsipeptide portion of antitumour antibiotic A83586C

Chapter 1 discusses the asymmetric synthesis of (3S)-hexahydropyridazine-3-carboxylic acid [(3S)-piperazic acid]. Two procedures were developed, firstly an electrophilic hydrazination of a chiral bromovaleryl carboximide enolate with di-tert-butylazodicarboxylate, followed by intramolecular SN2 displacement of the bromide by the resulting aza anion. Subsequent hydrolysis and acidolysis gave (3S)-piperazic acid in an enantiomeric excess greater than 96%. The second procedure was based on the formation of a titanium enolate from the chiral bromovaleryl carboximide at 0°C to form a hydrazine which was subsequently cyclised with the use of sodium hydride. Hydrolysis and acidolysis gave (3S)-piperazic acid in an enantiomeric excess of 78%. Chapter 2 is a concise review of the synthesis of natural cyclodepsipeptides between the years 1960 and 1994. Chapter 3 describes the evolution of a synthetic strategy for the cyclodepsipeptide portion of A83586C. A hexapeptide precursor has been prepared via a 3+2+1 fragment condensation

Mapping Regional Cortical Bone Responses to Local Changes in Loading and Systemic Stimuli

Quantification of cortical bone mass and architecture using μCT is commonplace in osteoporosis and osteoarthritis research. Different groups often report substantially divergent mouse cortical bone responses to nominally comparable interventions. In the case of studies assessing bones' responses to externally applied loading, these differences are commonly associated with methodological differences in the loading regime. This chapter describes a widely published, standardized method of in vivo mouse tibia axial loading to produce lamellar bone formation. Despite uniform application of axial loading, changes in bone mass are highly site-specific within individual bones. For example, the mouse proximal tibia rapidly accrues new bone following axial loading, but this osteogenic response tapers to produce undetectable differences distally. Consequently, the bone sites selected for comparisons substantially influence the magnitude of differences observed. Application of the freely available Site Specificity software allows site-specific responses to be identified by rapidly quantifying cortical bone mass at each 1% site along the bone's length. This high-content screening tool has been informatively applied to study the local effects of changes in loading as well as systemic interventions including hormonal treatment and aging. Automated multisite analyses of cortical mass is increasingly identifying site-specific effects of "systemic" interventions such as global gene deletions. Biological mechanisms underlying this apparent regionalization of cortical responses are largely unknown but may start to be elucidated by increasingly widespread application of Site Specificity methods

Bone gain following loading is site-specifically enhanced by prior and concurrent disuse in aged male mice

The primary aim of osteoanabolic therapies is to strategically increase bone mass in skeletal regions likely to experience high strains. In the young healthy skeleton, this is primarily achieved by bone's adaptation to loading. This adaptation appears to fail with age, resulting in osteoporosis and fractures. We previously demonstrated that prior and concurrent disuse enhances bone gain following loading in old female mice. Here, we applied site specificity micro-computed tomography analysis to map regional differences in bone anabolic responses to axial loading of the tibia between young (19-week-old) and aged (19-month-old), male and female mice. Loading increased bone mass specifically in the proximal tibia in both sexes and ages. Young female mice gained more cortical bone than young males in specific regions of the tibia. However, these site-specific sex differences were lost with age such that bone gain following loading was not significantly different between old males and females. To test whether disuse enhances functional adaption in old male mice as it does in females, old males were subjected to sciatic neurectomy or sham surgery, and loading was initiated four days after surgery. Disuse augmented tibial cortical bone gain in response to loading in old males, but only in regions which were load-responsive in the young. Prior and concurrent disuse also increased loading-induced trabecular thickening in the proximal tibia of old males. Understanding how diminished background loading rejuvenates the osteogenic loading response in the old may improve osteogenic exercise regimes and lead to novel osteoanabolic therapies

Quantification of Alterations in Cortical Bone Geometry Using Site Specificity Software in Mouse models of Aging and the Responses to Ovariectomy and Altered Loading.

Investigations into the effect of (re)modeling stimuli on cortical bone in rodents normally rely on analysis of changes in bone mass and architecture at a narrow cross-sectional site. However, it is well established that the effects of axial loading produce site-specific changes throughout bones' structure. Non-mechanical influences (e.g., hormones) can be additional to or oppose locally controlled adaptive responses and may have more generalized effects. Tools currently available to study site-specific cortical bone adaptation are limited. Here, we applied novel site specificity software to measure bone mass and architecture at each 1% site along the length of the mouse tibia from standard micro-computed tomography (μCT) images. Resulting measures are directly comparable to those obtained through μCT analysis (R (2) > 0.96). Site Specificity analysis was used to compare a number of parameters in tibiae from young adult (19-week-old) versus aged (19-month-old) mice; ovariectomized and entire mice; limbs subjected to short periods of axial loading or disuse induced by sciatic neurectomy. Age was associated with uniformly reduced cortical thickness and site-specific decreases in cortical area most apparent in the proximal tibia. Mechanical loading site-specifically increased cortical area and thickness in the proximal tibia. Disuse uniformly decreased cortical thickness and decreased cortical area in the proximal tibia. Ovariectomy uniformly reduced cortical area without altering cortical thickness. Differences in polar moment of inertia between experimental groups were only observed in the proximal tibia. Aging and ovariectomy also altered eccentricity in the distal tibia. In summary, site specificity analysis provides a valuable tool for measuring changes in cortical bone mass and architecture along the entire length of a bone. Changes in the (re)modeling response determined at a single site may not reflect the response at different locations within the same bone

CONDITION-BASED UNMANNED UNDERSEA VEHICLE MAINTENANCE MONITORING AND PREDICTION SYSTEM (C-BUMMPS)

As the Navy introduces its large displacement and extra-large class Unmanned Undersea Vehicles (UUVs), the need and desire grows for increased endurance on the order of weeks to months. Extended endurance is a necessary capability to enable UUVs to take on some of the mission areas of nuclear submarines. Energy efficiency and storage capacity are some of the first factors to be considered for extending the endurance of unmanned vehicles. However, a secondary and more challenging factor is UUV system reliability, and the ability to tolerate or avoid system failures. The intent of this project is to capture the stakeholder needs for improving UUV reliability, maintainability, and availability, then transform those needs into system requirements for a Condition-Based UUV Maintenance Monitoring and Prediction System (C-BUMMPS). Specifically, this project will develop and identify stakeholder, system functional, and system non-functional requirements. A C-BUMMPS architecture is developed to address the stakeholders’ needs. The developed architecture will consist of on-board sensing, monitoring, and processing elements on the UUV, in addition to ashore testing, data analytics, and maintenance activities needed to support the maturation of the C-BUMMPS. This project will utilize a model based systems engineering (MBSE) approach, and Innoslate was chosen as the desired MBSE tool. As such, certain views will be developed to depict the C-BUMMPS architecture from various perspectives.Civilian, Department of the NavyCivilian, Department of the NavyCivilian, Department of the NavyCivilian, Department of the NavyApproved for public release. Distribution is unlimited