Effects of Ursolic Acid and its Analogues on Soybean 15-Lipoxygenase Activity and the Proliferation Rate of A human Gastric Tumour Cell Line

The authors have previously isolated and purified ursolic acid from heather flowers (Calluna vulgarts). This terpene was found to inhibit HL-60 leukaemic cell proliferation and arachidonic acid oxidative metabolism in various cell species. The effects of ursolic acid and its analogues on soybean 15-lipoxygenase activity and on the proliferation of a human gastric tumour cell line (HGT), have been assessed. These triterpenes inhibited soybean 15-lipoxygenase at its optimal activity (pH 9). The proliferation ofHGT was decreased in a dose-dependent manner. At 20 μM the rank order is: ursolic acid > uvaol > oleanolic acid > methyl ursolate. The carboxylic group at the C28 position of ursolic acid appears to be implicated in the inhibition of both lipoxygenase activity and cell proliferation. Thus methylation of this group decreases these two inhibitory properties. Oleanolic acid, which differs by the position of one methyl group (C20 instead of C19) is less inhibitory than ursolic acid. The lipophilicity of the terpene is also implicated since uvaol appears to be more inhibitory than methyl ursolate

Effect of particle size on the measurement of the apparent contact angle in sand of varying wettability under air-dried conditions

Session: Advances in Experimental Methods: Mechanical PropertiesChanges in the wettability of soil are known to affect several processes such as infiltration and the shear strength of soil. In this study, the wettability of a medium to fine sand was chemically modified by using different concentrations of dimethyldichlorosilane (DMDCS). The sessile drop method (SDM) was used for the assessment of wettability of hydrophobised Leighton Buzzard Sand (LBS). The results demonstrate that beyond a concentration of 2 g per kg of LBS, the finer fraction had its apparent contact angle (ACA) increased up to 115° while the maximum ACA attained by the coarser fractions was 100°. At such high concentration of DMDCS, the effect of trapped air, which is known to increase the ACA, was found to be either small or insignificant. The standard deviations of the ACAs agreed well with past studies. The most important factors contributing to the water-repellent behaviour of chemically synthesised sand were attributed to the characteristics of the particles; these include surface area and particle shape.published_or_final_versio

Resonance Patterns of an Antidot Cluster: From Classical to Quantum Ballistics

We explain the experimentally observed Aharonov-Bohm (AB) resonance patterns of an antidot cluster by means of quantum and classical simulations and Feynman path integral theory. We demonstrate that the observed behavior of the AB period signals the crossover from a low B regime which can be understood in terms of electrons following classical orbits to an inherently quantum high B regime where this classical picture and semiclassical theories based on it do not apply.Comment: 5 pages revtex + 2 postscript figure

Enquête sur l'infection naturelle du chien militaire au Maroc par le virus de Rubarth

Petrov Y.-J.-M., Delage B., Martin L.- A. Enquête sur l'infection naturelle du Chien militaire au Maroc par le virus de Rubarth. In: Bulletin de l'Académie Vétérinaire de France tome 111 n°7, 1958. pp. 341-346

Testing surfactants as additives for clay improvement: compaction and suction effects

Environmental Geotechnics (Joint TC106-TC215 Session)This paper presents an exploratory study on surfactants as additives to improve soil properties. It is hypothesized that surfactant molecules populate the air-water interfaces reducing surface tension and suction thus allowing a control of the mechanical response of the soil. Suction measurements by means of a high suction tensiometer, compaction tests and Atterberg limits were conducted in mixtures of sand and kaolin, with and without a surfactant solution. The results revealed a prominent effect on suction, but to a lesser extent on the Atterberg limits and compaction behavior (the maximum dry density). This targeted effect of the surfactants suggests its molecules populate, not only the air-water interfaces decreasing surface tension, but may be adsorbing to the clay particles and forming micelles in the pore water as well. Therefore the interplay between the three may influence the soil behavior.published_or_final_versio

Fractal Conductance Fluctuations in a Soft Wall Stadium and a Sinai Billiard

Conductance fluctuations have been studied in a soft wall stadium and a Sinai billiard defined by electrostatic gates on a high mobility semiconductor heterojunction. These reproducible magnetoconductance fluctuations are found to be fractal confirming recent theoretical predictions of quantum signatures in classically mixed (regular and chaotic) systems. The fractal character of the fluctuations provides direct evidence for a hierarchical phase space structure at the boundary between regular and chaotic motion.Comment: 4 pages, 4 figures, data on Sinai geometry added to Fig.1, minor change

The role of the South Pacific in modulating Tropical Pacific variability

Tropical Pacific variability (TPV) heavily influences global climate, but much is still unknown about its drivers. We examine the impact of South Pacific variability on the modes of TPV: the El Niño-Southern Oscillation (ENSO) and the Interdecadal Pacific Oscillation (IPO). We conduct idealised coupled experiments in which we suppress temperature and salinity variability at all oceanic levels in the South Pacific. This reduces decadal variability in the equatorial Pacific by ~30% and distorts the spatial pattern of the IPO. There is little change to overall interannual variability, however there is a decrease in the magnitude of the largest 5% of both El Niño and La Niña sea-surface temperature (SST) anomalies. Possible reasons for this include: (i) reduced decadal variability means that interannual SST variability is superposed onto a ‘flatter’ background signal, (ii) suppressing South Pacific variability leads to the alteration of coupled processes linking the South and equatorial Pacific. A small but significant mean state change arising from the imposed suppression may also contribute to the weakened extreme ENSO SST anomalies. The magnitude of both extreme El Niño and La Niña SST anomalies are reduced, and the associated spatial patterns of change of upper ocean heat content and wind stress anomalies are markedly different for both types of events

Research collaboration in solar radiometry between the University of Reunion Island and the University of Kwazulu-Natal

Paper presented to the 3rd Southern African Solar Energy Conference, South Africa, 11-13 May, 2015.Since 2012, the Universities of KwaZulu-Natal and Reunion Island have collaborated on a joint programme of solar energy research. The initiative has two principle aims: the development of solar forecasting techniques and the expansion of solar monitoring capabilities from continental Africa into the southern Indian Ocean region. In this paper, we introduce the programme and review the progress made. A key activity is performance validation of a low-cost radiometric sensor, the Delta-T Devices SPN1, which has been operated at a UKZN ground station for comparison against reference sensors. The instrument potentially represents an opportunity to expand existing radiometric networks by reducing the cost of ground station facilities. A novel feature of the device is its use of seven thermopile sensors and a stationery shading mask which together enable the simultaneous measurement of global horizontal and diffuse horizontal irradiance. It is important that the instrument performance should first be assessed, however, so that its measurement uncertainty is known ahead of deployment. Data from the UKZN trial are included in the paper, along with a description of a meteorological classification system that may be used in solar forecasting systems. The system is based on the direct solar fraction, that is, the ratio of direct horizontal irradiance to global horizontal irradiance. A clustering methodology is described and sample data are provided to illustrate the ability of the method to segregate days into statistically significant bins.cf201