Scale Invariant Interest Points with Shearlets

Shearlets are a relatively new directional multi-scale framework for signal analysis, which have been shown effective to enhance signal discontinuities such as edges and corners at multiple scales. In this work we address the problem of detecting and describing blob-like features in the shearlets framework. We derive a measure which is very effective for blob detection and closely related to the Laplacian of Gaussian. We demonstrate the measure satisfies the perfect scale invariance property in the continuous case. In the discrete setting, we derive algorithms for blob detection and keypoint description. Finally, we provide qualitative justifications of our findings as well as a quantitative evaluation on benchmark data. We also report an experimental evidence that our method is very suitable to deal with compressed and noisy images, thanks to the sparsity property of shearlets

Detecting spatio-temporally interest points using the shearlet transform

In this paper we address the problem of detecting spatio-temporal interest points in video sequences and we introduce a novel detection algorithm based on the three-dimensional shearlet transform. By evaluating our method on different application scenarios, we show we are able to extract meaningful spatio-temporal features from video sequences of human movements, including full body movements selected from benchmark datasets of human actions and human-machine interaction sequences where the goal is to segment drawing activities in smaller action primitives

Space-Time Signal Analysis and the 3D Shearlet Transform

In this work, we address the problem of analyzing video sequences by representing meaningful local space\ue2\u80\u93time neighborhoods. We propose a mathematical model to describe relevant points as local singularities of a 3D signal, and we show that these local patterns can be nicely highlighted by the 3D shearlet transform, which is at the root of our work. Based on this mathematical framework, we derive an algorithm to represent space\ue2\u80\u93time points which is very effective in analyzing video sequences. In particular, we show how points of the same nature have a very similar representation, allowing us to compute different space\ue2\u80\u93time primitives for a video sequence in an unsupervised way

Unitarization and Inversion Formulae for the Radon Transform Between Dual Pairs

We consider the Radon transform associated to dual pairs (X,\u39e) in the sense of Helgason, with X = G/K and \u39e = G/H, where G is a locally compact group and K and H are closed subgroups of G. Under some technical assumptions, we prove that if the quasi-regular representations of G acting on L2(X) and L2(\u39e) are irreducible, then the Radon transform admits a unitarization intertwining the two representations. If, in addition, the representations are square- integrable, we provide an inversion formula for the Radon transform based on the voice transform associated to these representations

A New Surgical Approach for Direct Acoustic Cochlear Implant: A Temporal Bone Study

The direct acoustic cochlear implant (DACI) is among the latest developments in the field of implantable acoustic prostheses. The surgical procedure requires a mastoidectomy and a posterior-inferior tympanotomy, with access to the facial recess at the level of the oval window, in a complex and lengthy surgical approach. Here, we report a new and considerably shorter surgical approach

RNA-Binding protein HuR and the members of miR-200 family play an unconventional role in the regulation of c-Jun mRNA

Post-transcriptional gene regulation is a fundamental step for coordinating cellular response in a variety of processes. RNA-binding proteins (RBPs) and microRNAs (miRNAs) are the most important factors responsible for this regulation. Here we report that different components of the miR-200 family are involved in c-Jun mRNA regulation with the opposite effect. While miR-200b inhibits c-Jun protein production, miR-200a tends to increase the JUN amount through a stabilization of its mRNA. This action is dependent on the presence of the RBP HuR that binds the 3′UTR of c-Jun mRNA in a region including the mir-200a binding site. The position of the binding site is fundamental; by mutating this site, we demonstrate that the effect is not micro-RNA specific. These results indicate that miR-200a triggers a microRNA-mediated stabilization of c-Jun mRNA, promoting the binding of HuR with c-Jun mRNA. This is the first example of a positive regulation exerted by a microRNA on an important oncogene in proliferating cells

Lithium limits trimethyltin-induced cytotoxicity and proinflammatory response in microglia without affecting the concurrent autophagy impairment

Trimethyltin (TMT) is a highly toxic molecule present as an environmental contaminant causing neurodegeneration particularly of the limbic system both in humans and in rodents. We recently described the occurrence of impairment in the late stages of autophagy in TMT-intoxicated astrocytes. Here we show that similarly to astrocytes also in microglia, TMT induces the precocious block of autophagy indicated by the accumulation of the autophagosome marker, microtubule associated protein light chain 3. Consistent with autophagy impairment we observe in TMT-treated microglia the accumulation of p62/SQSTM1, a protein specifically degraded through this pathway. Lithium has been proved effective in limiting neurodegenerations and, in particular, in ameliorating symptoms of TMT intoxication in rodents. In our in vitro model, lithium displays a pro-survival and anti-inflammatory action reducing both cell death and the proinflammatory response of TMT-treated microglia. In particular, lithium exerts these activities without reducing TMT-induced accumulation of light chain 3 protein. In fact, the autophagic block imposed by TMT is unaffected by lithium administration. These results are of interest as defects in the execution of autophagy are frequently observed in neurodegenerative diseases and lithium is considered a promising therapeutic agent for these pathologies. Thus, it is relevant that this cation can still maintain its pro-survival and anti-inflammatory role in conditions of autophagy bloc