23 research outputs found
Efficacy and Safety of Prucalopride in Patients with Chronic Noncancer Pain Suffering from Opioid-Induced Constipation
Opioid-induced constipation (OIC) has negative effects on quality of life (QOL). Prucalopride is a new, selective 5-HT4 agonist and enterokinetic with strong clinical data in chronic constipation. This study investigated the efficacy, safety, and tolerability of prucalopride in patients with noncancer pain and OIC. A phase II, double-blind, placebo-controlled study of 196 patients randomized to placebo (n = 66), prucalopride 2 mg (n = 66) or 4 mg (n = 64), for 4 weeks, was carried out. The primary endpoint was the proportion of patients with increase from baseline of a parts per thousand yen1 spontaneous complete bowel movement (SCBM)/week. Secondary endpoints [proportion of patients with a parts per thousand yen3 SCBM/week, weekly frequency of (SC)BM, severity of constipation, and efficacy of treatment], adverse events (AEs), and safety parameters were also monitored. More patients had an increase from baseline of a parts per thousand yen1 SCBM per week (weeks 1-4) in the prucalopride groups [35.9% (2 mg) and 40.3% (4 mg)] versus placebo (23.4%), reaching statistical significance in week 1. Over weeks 1-4, more patients in the prucalopride groups achieved an average of a parts per thousand yen3 SBM per week versus placebo (60.7% and 69.0% versus 43.3%), reaching significance at week 1. Prucalopride 4 mg significantly improved patient-rated severity of constipation and effectiveness of treatment versus placebo. Patient Assessment of Constipation-Symptom (PAC-SYM) total scores and Patient Assessment of Constipation-Quality of Life (PAC-QOL) total and satisfaction subscale scores were improved. The most common AEs were abdominal pain and nausea. There were no clinically relevant differences between groups in vital signs, laboratory measures or electrocardiogram parameters. In this population with OIC, prucalopride improved bowel function and was safe and well tolerated
Magnetotransport of CeRhIn5
We report measurements of the temperature-dependent anisotropic resistivity
and in-plane magnetoresistance on single crystals of the tetragonal
heavy-fermion antiferromagnet (TN = 3.8 K) CeRhIn5. The measurements are
reported in the temperature range 1.4 K to 300 K and in magnetic fields to 18
tesla. The resistivity is moderately anisotropic, with a room-temperature
c-axis to in-plane resistivity ratio rho_c/rho_a(300 K) = 1.7. rho(T)
measurements on the non-magnetic analog LaRhIn5 indicate that the anisotropy in
the CeRhIn5 resistivity stems predominately from anisotropy in Kondo-derived
magnetic scattering. In the magnetically ordered regime an applied field H
reduces TN only slightly due to the small ordered moment (0.37mu_B) and
magnetic anisotropy. The magnetoresistance (MR) below TN is positive and varies
linearly with H. In the paramagnetic state a positive MR is present below 7.5
K, while a high-field negative contribution is evident at higher temperatures.
The positive contribution decreases in magnitude with increasing temperature.
Above 40 K the positive contribution is no longer observable, and the MR is
negative. The low-T positive MR results from interactions with the
Kondo-coherent state, while the high-T negative MR stems from single-impurity
effects. The H and T-dependent magnetotransport reflects the magnetic
anisotropy and Kondo interactions at play in CeRhIn5.Comment: submitted to Physical Review
Recherches Philosophiques Sur Les Egyptiens Et Les Chinois
Par Mr. De P*** [De Pauw] [erm. Verf.]Vorlageform der Veröffentlichungsangabe: A Berlin. Chez G. J. Decker, Imprimeur du Ro
Philosophische Untersuchungen über die Aegypter und Chineser : Nebst einer Carte von der berühmten großen Mauer in dem alten Aegypten
Aus dem Französischen des Hrn. von P*** übersetzt von D. J. G. KrünitzVorlageform der Veröffentlichungsangabe: Berlin, bei George Jacob DeckerErschienen: 1 (1774) - 2 (1774
Philosophische Untersuchungen über die Amerikaner, oder, Wichtige Beyträge zur Geschichte des menschlichen Geschlechts
aus dem Französischen des Herrn v. P*** [Cornelius de Pauw ; übers. von Carl Gottlieb Lessing]Titeleinfassung, -vignette und Titel in Rot- und SchwarzdruckVerfasser und Übersetzer gemäss Dt. Anonymen-LexikonOriginaltitel: Recherches philosophiques sur les Américains, ou, Mémoires intéressants pour servir à l'histoire de l'espèce humain