Autoimmunity and otolaryngology diseases

Many systemic autoimmune diseases have otolaryngology manifestations that could represent a diagnostic challenge for clinicians, as they often constitute an early sign of an otherwise asymptomatic autoimmune condition and may lead to delayed diagnosis and treatment. In other cases, otolaryngology manifestations can be overlooked in patients with previously diagnosed autoimmune diseases. The pres- ence of concomitant conditions, the heterogeneity of studies available in the literature, and the lack of randomized trials are factors that may limit the prompt diagnosis of otolaryn- gology manifestations in systemic autoimmune diseases, with underestimation of the problem and undertreatment of the related condition

Audio-vestibular symptoms in systemic autoimmune diseases

Immune-mediated inner ear disease can be primary, when the autoimmune response is against the inner ear, or secondary. The latter is characterized by the involvement of the ear in the presence of systemic autoimmune conditions. Sensorineural hearing loss is the most common audiovestibular symptom associated with systemic autoimmune diseases, although conductive hearing impairment may also be present. Hearing loss may present in a sudden, slowly, rapidly progressive or fluctuating form, and is mostly bilateral and asymmetric. Hearing loss shows a good response to corticosteroid therapy that may lead to near-complete hearing restoration. Vestibular symptoms, tinnitus, and aural fullness can be found in patients with systemic autoimmune diseases; they often mimic primary inner ear disorders such as Menière’s disease and mainly affect both ears simultaneously. Awareness of inner ear involvement in systemic autoimmune diseases is essential for the good response shown to appropriate treatment. However, it is often misdiagnosed due to variable clinical presentation, limited knowledge, sparse evidence, and lack of specific diagnostic tests. The aim of this review is to analyse available evidence, often only reported in the form of case reports due to the rarity of some of these conditions, of the different clinical presentations of audiological and vestibular symptoms in systemic autoimmune diseases

Hearing loss, tinnitus, hyperacusis, and diplacusis in professional musicians: a systematic review

Professional musicians (PMs) are at high risk of developing hearing loss (HL) and other audiological symptoms such as tinnitus, hyperacusis, and diplacusis. The aim of this systematic review is to (A) assess the risk of developing HL and audiological symptoms in PMs and (B) evaluate if different music genres (Pop/Rock Music-PR; Classical Music-CL) expose PMs to different levels of risk of developing such conditions. Forty-one articles including 4618 PMs were included in the study. HL was found in 38.6% PMs; prevalence was significantly higher among PR (63.5%) than CL (32.8%) PMs; HL mainly affected the high frequencies in the 3000-6000 Hz range and was symmetric in 68% PR PMs and in 44.5% CL PMs. Tinnitus was the most common audiological symptom, followed by hyperacusis and diplacusis. Tinnitus was almost equally distributed between PR and CL PMs; diplacusis was more common in CL than in PR PMs, while prevalence of hyperacusis was higher among PR PMs. Our review showed that PR musicians have a higher risk of developing HL compared to CL PMs; exposure to sounds of high frequency and intensity and absence of ear protection may justify these results. Difference in HL symmetry could be explained by the type of instruments used and consequent single-sided exposure

Somatic tinnitus

Modulation of tinnitus characteristics such as pitch and loudness has been extensively described following movements of the head, neck and limbs, vertical or horizontal eye gaze, pressure on myofascial trigger points, cutaneous stimulation of the hands, electrical stimulation of the median nerve, and transcranial direct current stimulation. Modulation of tinnitus follows complex interactions between auditory and somatosensory afferents and can be favored by underlying somatic disorders. When tinnitus appears to be preceded or strictly linked to a somatic disorder, and therefore related to problems of the musculoskeletal system rather than of the ear, it is defined somatic tinnitus. A correct diagnosis and treatment of somatic disorders underlying tinnitus play a central role for a correct management of somatic tinnitus. However, the identification of somatic tinnitus may be complex in some cases. In this paper, after a general review of the current evidences for somatic tinnitus available in the literature, we present and discuss some cases of patients in which somatic modulation of tinnitus played a role - although different from case to case - in their tinnitus, describing the diagnostic and therapeutic approaches followed in each individual case and the results obtained, also highlighting unexpected findings and pitfalls that may be encountered when approaching somatic tinnitus patients

Improved processing methods to reduce the total cyanide content of cassava roots from Burundi

The identification of highly effective procedures that reduce the cyanogens contained in cassava roots which require no sophisticated equipment, and can readily be adopted by subsistence farmers is of tremendous importance. This study, which used cassava root samples collected in Burundi, included fermentation tests using both selected and native cultures at different temperatures for variable times. Moreover, drying procedures with and without fermentation were carried out. A factorial analysis of variance (ANOVA) showed that the detoxification was mainly affected by fermentation length and by the initial cyanogens content of the roots. When fermentation lasted 48 h and the initial cyanide level was lower than 300 mg/kg dry weight (d.w.), the detoxification was also found to vary based on the microorganism inoculated; Saccharomyces cerevisiae demonstrated the greatest effectiveness. In terms of drying conditions, a temperature of 60°C, even for a shorter duration of time (8 h), lowered the initial cyanide level by more than 90%. Finally, when dehydration followed fermentation, the pressed pulp showed a substantial reduction in cyanide content. By means of this last procedure, safe cassava was produced according to FAO/WHO amendments (10 mg HCN equivalent per kilogram flour), if the initial cyanide level of roots did not exceed 200 mg/kg d.w. Actually, the initial maximum total cyanide content was confirmed to be fundamental in order to obtain safe products in relation to processing method adopted.Keywords: Cassava, cyanide, detoxification, drying, fermentation.African Journal of Biotechnology Vol. 12(19), pp. 2685-269

Otolaryngologic symptoms in multiple sclerosis: a review

Many symptoms of multiple sclerosis may affect the ear, nose and throat. The most common otolaryngologic symptoms of multiple sclerosis are speech disorders, followed by sleep disorders, vertigo and disequilibrium, dysphagia, smell alterations, and hearing loss. Less common symptoms include sialorrhea, facial palsy, taste alterations, trigeminal neuralgia and tinnitus. The origin of otolaryngologic symptoms in multiple sclerosis is mainly central, although increasing evidence also suggests a peripheral involvement. Otolaryngologic symptoms in multiple sclerosis may have different clinical presentations; they can appear in different stages of the pathology, in some cases they can be the presenting symptoms and their worsening may be correlated with reactivation of the disease. Many of these symptoms significantly affect the quality of life or patients and lead to increased morbidity and mortality. Otolaryngologic symptoms are common in multiple sclerosis; however, they are often overlooked. In many cases, they follow the relapsing-remitting phases of the disease, and may spontaneously disappear, leading to a delay in multiple sclerosis diagnosis. Clinicians should be aware of otolaryngologic symptoms of multiple sclerosis, especially when they are associated to neurologic symptoms, as they may be early signs of a still undiagnosed multiple sclerosis or could help monitor disease progression in already diagnosed patients

Investigation of the Role of the Environment on the Photoluminescence and the Exciton Relaxation of CsPbBr3 Nanocrystals Thin Films

In this work, we present a detailed optical investigation of the effects of the environment on the photoluminescence (PL) spectra and the relaxation dynamics of pristine and aged CsPbBr 3 nanocrystal (NC) thin films. We demonstrate that, contrary to previous results on similar NCs, the PL intensity of pristine NCs is higher when the sample is in wet air than in vacuum, due to the passivation of defects reducing the free exciton trapping and the bound excitons non-radiative relaxation. The aged NCs show a PL intensity increase in wet air nine times stronger than the pristine ones, due to an interplay between static and dynamic effects, increasing the number of emitting NCs and reducing the non-radiative recombination rate of free excitons. These results improve the understanding of the possible interactions between perovskite NCs and the environment, which could be relevant for the development of optical gas sensors exploiting perovskite NCs

Selective transcriptional regulation by Myc: Experimental design and computational analysis of high-throughput sequencing data

AbstractThe gene expression programs regulated by the Myc transcription factor were evaluated by integrated genome-wide profiling of Myc binding sites, chromatin marks and RNA expression in several biological models. Our results indicate that Myc directly drives selective transcriptional regulation, which in certain physiological conditions may indirectly lead to RNA amplification. Here, we illustrate in detail the experimental design concerning the high-throughput sequencing data associated with our study (Sabò et al., Nature. (2014) 511:488–492) and the R scripts used for their computational analysis