Obstetric outcomes in pregnant COVID-19 women: the imbalance of von Willebrand factor and ADAMTS13 axis

Background: Thrombotic microangiopathy has been invoked as one of the most important mechanisms of damage in COVID-19 patients. Protease ADAMTS13 is a marker of microangiopathy responsible for controlling von Willebrand multimers size. Von Willebrand factor/ADAMTS13 ratio has been found impaired in COVID-19 patients outside pregnancy. Methods: We prospectively investigated 90 pregnant women admitted to two tertiary academic hospitals in Italy with a laboratory-confirmed diagnosis of SARS-CoV-2 infection. Demographic, clinical information and routine laboratory data were collected at the hospital admission and until discharge. We investigated whether vonWillebrand /ADAMTS13 axis imbalance is a predictor of adverse outcomes. Logistic regression analysis, which controlled for potential confounders, was performed to evaluate the association between laboratory parameters and clinical outcomes. Results: Most women (55.6%) were parae, with median gestational age at admission of 39 weeks. At hospital admission, 63.3% were asymptomatic for COVID-19 and 24.4% showed more than one sign or symptom of infection. Nulliparae with group O showed Willebrand / ADA MTS-13 ratios significantly lower than non-O, whereas in multiparae this difference was not observed. Logistic regression showed that ratio von Willebrand to ADAMTS13 was significantly and independently associated with preterm delivery (OR 1.9, 95%CI 1.1–3.5). Conclusion: This study shows an imbalance of vonWillebrand /ADAMTS13 axis in pregnant women with COVID-19, leading to a significantly higher and independent risk of preterm delivery. Monitoring these biomarkers might support decision making process to manage and follow-up pregnancies in this setting

Anemone study: prevalence of risk factors for superficial vein thrombosis in a large Italian population of blood donors

Knowledge of the distribution of risk factors for superficial thrombosis (SVT) in low-risk population is fundamental to improve the prevention of the disease in each individual and high-risk settings of patients. Exact frequency data for the low-risk population are scarce, but could be useful for optimal use of prophylactic strategies against venous thrombosis. Blood donors represent a low-risk population, because are healthier than the general population. The objective of this study was to assess the prevalence of vein thrombosis, particularly SVT, and associated risk factors in a low-risk population such as blood donors. In this multicentre cross-sectional study, donors from six Italian blood banks responded to a self-administered questionnaire. The enrolment lasted from 1st June 2017 to 30th July 2018. History of vein thrombosis was referred by 89 (0.76%) individuals, (49 men) with an age-dependent effect. The prevalence reached 2.9% in women and 0.8% in men aged ≥ 49 years, with a significant difference only for women. After controlling for potential confounders, a significant and independent association was found between a history of vein thrombosis and age (OR: 1.03, 95%CI 1.01–1.05), varicose veins (OR: 15.8, 95%CI 7.7–32.6), plaster cast/bed rest (OR: 2.3, 95% CI 1.0–5.3) and transfusion (OR: 5.1, 95% CI 1.3–19.5). This study shows that low-risk individuals share the same risk factors for SVT as patients in secondary care. It also suggests that transfusion confers an increased risk of SVT in healthy population

Correction to: Use of low-molecular weight heparin, transfusion and mortality in COVID-19 patients not requiring ventilation (Journal of Thrombosis and Thrombolysis, (2021), 52, 3, (772-778), 10.1007/s11239-021-02429-z)

none63In the original version of the article, the group was mentioned incorrectly. The correct name is "CSS COVID-19 Group". Also, in the Table 4 the p for ICU access and CKD were 0.024 (instead of 0.24) and 0.006 (instead of 0.06). These have been corrected with this erratum.noneGrandone E.; Tiscia G.; Pesavento R.; De Laurenzo A.; Ceccato D.; Sartori M.T.; Mirabella L.; Cinnella G.; Mastroianno M.; Dalfino L.; Colaizzo D.; Vettor R.; Intrieri M.; Ostuni A.; Margaglione M.; Alboini P.E.; Antonioni A.; Aucella F.; Bochicchio G.B.; Carbonelli C.; Carella M.; Castori M.; Centonze A.; Ciliberti G.; Copetti M.; Corritore M.; De Cosmo S.; D'Aloiso L.; D'Errico M.M.; de Matthaeis A.; Del Gaudio A.; Di Giorgio A.; Giambra V.; Greco A.; Florio L.; Fontana A.; Inchingolo V.; Inglese M.; Labonia M.; La Marca A.; Latiano T.; Leone M.; Maiello E.; Mangia A.; Marciano C.; Massa V.; Massafra S.; Orciulo G.; Palladino N.; Perna R.; Piscitelli P.; Piemontese M.; Prencipe M.A.; Raggi P.; Rodriquenz M.G.; Russo R.; Sancarlo D.; Simeone A.; Trischitta V.; Zarrelli M.; Vaira P.; Vergara D.; Vescovi A.Grandone, E.; Tiscia, G.; Pesavento, R.; De Laurenzo, A.; Ceccato, D.; Sartori, M. T.; Mirabella, L.; Cinnella, G.; Mastroianno, M.; Dalfino, L.; Colaizzo, D.; Vettor, R.; Intrieri, M.; Ostuni, A.; Margaglione, M.; Alboini, P. E.; Antonioni, A.; Aucella, F.; Bochicchio, G. B.; Carbonelli, C.; Carella, M.; Castori, M.; Centonze, A.; Ciliberti, G.; Copetti, M.; Corritore, M.; De Cosmo, S.; D'Aloiso, L.; D'Errico, M. M.; de Matthaeis, A.; Del Gaudio, A.; Di Giorgio, A.; Giambra, V.; Greco, A.; Florio, L.; Fontana, A.; Inchingolo, V.; Inglese, M.; Labonia, M.; La Marca, A.; Latiano, T.; Leone, M.; Maiello, E.; Mangia, A.; Marciano, C.; Massa, V.; Massafra, S.; Orciulo, G.; Palladino, N.; Perna, R.; Piscitelli, P.; Piemontese, M.; Prencipe, M. A.; Raggi, P.; Rodriquenz, M. G.; Russo, R.; Sancarlo, D.; Simeone, A.; Trischitta, V.; Zarrelli, M.; Vaira, P.; Vergara, D.; Vescovi, A