6 research outputs found
Retrospective French nationwide survey of childhood aggressive vascular anomalies of bone, 1988-2009
<p>Abstract</p> <p>Objective</p> <p>To document the epidemiological, clinical, histological and radiological characteristics of aggressive vascular abnormalities of bone in children.</p> <p>Study design</p> <p>Correspondents of the French Society of Childhood Malignancies were asked to notify all cases of aggressive vascular abnormalities of bone diagnosed between January 1988 and September 2009.</p> <p>Results</p> <p>21 cases were identified; 62% of the patients were boys. No familial cases were observed, and the disease appeared to be sporadic. Mean age at diagnosis was 8.0 years [0.8-16.9 years]. Median follow-up was 3 years [0.3-17 years]. The main presenting signs were bone fracture (n = 4) and respiratory distress (n = 7), but more indolent onset was observed in 8 cases. Lung involvement, with lymphangiectasies and pleural effusion, was the most frequent form of extraosseous involvement (10/21). Bisphosphonates, alpha interferon and radiotherapy were used as potentially curative treatments. High-dose radiotherapy appeared to be effective on pleural effusion but caused major late sequelae, whereas antiangiogenic drugs like alpha interferon and zoledrenate have had a limited impact on the course of pulmonary complications. The impact of bisphosphonates and alpha interferon on bone lesions was also difficult to assess, owing to insufficient follow-up in most cases, but it was occasionally positive. Six deaths were observed and the overall 10-year mortality rate was about 30%. The prognosis depended mainly on pulmonary and spinal complications.</p> <p>Conclusion</p> <p>Aggressive vascular abnormalities of bone are extremely rare in childhood but are lifethreatening. The impact of anti-angiogenic drugs on pulmonary complications seems to be limited, but they may improve bone lesions.</p
Introduction to French Culture
Ce cours est une introduction à la culture et la société françaises depuis la Révolution, mais surtout à partir du Second Empire. Nous tacherons de cerner ce qui définit la singularité francaise dans une perspective historique. Nous commencerons avec la notion "d'exception francaise" et de ce qui la constitue depuis la Révolution (La République, L'Universalisme, La Laicité, etc.) Nous explorerons l'impact de l'industrialisation, ainsi que la tension entre la France pays de la modernité dans les arts et la technologie et la France nostalgique de sa grandeur passée. Nous discuterons les moments charnières de cette tension avec les grands débats d'idées autour des impressionistes, de "Fleurs du Mal", du Paris de Haussmann, de la construction de la Tour Eiffel, des expositions universelles et coloniales. Nous analyserons la représentation littéraire et filmique des moments historiques et des crises hexagonales qui ont marqué le 20e siècle: l'Affaire Dreyfus, les deux guerres mondiales le colonialisme et la guerre d'Algérie, Mai 68. A travers des textes, des images, des articles de journaux, des films, nous tenteront de faire le lien entre cette histoire et les débats contemporrains sur l'identité Française
Violette Leduc : L'enfermée pÚlerine
de Courtivron Isabelle. Violette Leduc : L'enfermée pÚlerine. In: Les Cahiers du GRIF, n°39, 1988. recluses vagabondes. pp. 49-53