Factors for analysing and improving performance of R&D in Malaysian universities

This paper presents a model for analysing and improving performance of R&D in Malaysian universities. There are various general models for R&D analysis, but none is specific for improving the performance of R&D in Malaysian universities. This research attempts to fill a gap in the body of knowledge with regard to developing countries by explicitly focusing on factors that are relevant for analysing and improving R&D performance in Malaysian universities.\ud The project's methodology essentially entails a deductive route to identify and progressively refine the factors that determine R&D performance. It is based on extensive literature study aimed at developing a model that is appropriate for researching and improving R&D in an emerging economy. The paper addresses the development of the model and the research project’s approach. This model will be applied in collecting data from surveys and a number of field studies. The results will be used to improve the model as well as recommending points of improvement for Malaysian universities

On the Holographic Renormalization Group

We propose a direct correspondence between the classical evolution equations of 5-d supergravity and the renormalization group (RG) equations of the dual 4-d large $N$ gauge theory. Using standard Hamilton-Jacobi theory, we derive first order flow equations for the classical supergravity action $S$, that take the usual form of the Callan-Symanzik equations, including the corrections due to the conformal anomaly. This result gives direct support for the identification of $S$ with the quantum effective action of the gauge theory. In addition we find interesting new relations between the beta-functions and the counterterms that affect the 4-d cosmological and Newton constant

Does Disclosure of Performance Information Influence Street-level Bureaucrats' Enforcement Style?

Governments use different regulatory instruments to ensure that businesses owners or "inspectees" comply with rules and regulations. One tool that is increasingly applied is disclosing inspectees' performance information to other stakeholders. Disclosing performance information has consequences for street-level bureaucrats because it increases the visibility of their day-to-day work. Using a survey (n =507) among Dutch inspectors of the Netherlands Food and Consumer Product Safety Authority, this article shows that the disclosure of performance information has an impact on enforcement style at the street level. Findings show that perceived disclosed performance information positively enhances all three dimensions of street-level bureaucrats' enforcement style (legal, facilitation, and accommodation). This effect is strongest for facilitation and accommodation and weakest for the legal style. Perceived resistance by inspectees partly explains this effect. Contrary to expectations, more perceived disclosure does not result in more but in less perceived resistance of inspectees by street-level bureaucrats

Blaming the bureaucrat: does perceived blame risk influence inspectors’ enforcement style?

Is there a relation between street-level bureaucrats’ enforcement style and their perception of the risk of getting blamed? This article answers this question on the basis of a survey (n = 507) among inspectors of the Netherlands Food and Product Safety Authority. We included perceived media attention on their work as a factor that might influence street-level bureaucrats’ perception of blame risk and their enforcement style. Three dimensions of enforcement style were distinguished from earlier research: legal, facilitative and accommodative. We found that when inspectors perceive more blame risk, they employ a slightly less legal style and, instead, employ a more accommodative style. Thus, they act a little less formally and less coercively (i.e. legal) and take greater account of their peers’ opinions (i.e. accommodative). However, perceived media attention did not have a significant influence on enforcement style. Points for practitioners: 1. When inspectors perceive more blame risk, they tend to pay more attention to the opinion of peers (other inspectors, supervisors, etc.). 2. Blame risk does not lead to the use of a more formal inspection style. 3. Media attention does not play an important role in enhancing the blame risk perception of inspectors. 4. This media and blame risk is less important than often found in the case of politicians. This may be connected to the fact that the work of inspectors as street-level bureaucrats is less visible to the wider public (and the media)

The chiral ring of AdS3/CFT2 and the attractor mechanism

We study the moduli dependence of the chiral ring in N = (4,4) superconformal field theories, with special emphasis on those CFTs that are dual to type IIB string theory on AdS3xS3xX4. The chiral primary operators are sections of vector bundles, whose connection describes the operator mixing under motion on the moduli space. This connection can be exactly computed using the constraints from N = (4,4) supersymmetry. Its curvature can be determined using the tt* equations, for which we give a derivation in the physical theory which does not rely on the topological twisting. We show that for N = (4,4) theories the chiral ring is covariantly constant over the moduli space, a fact which can be seen as a non-renormalization theorem for the three-point functions of chiral primaries in AdS3/CFT2. From the spacetime point of view our analysis has the following applications. First, in the case of a D1/D5 black string, we can see the matching of the attractor flow in supergravity to RG-flow in the boundary field theory perturbed by irrelevant operators, to first order away from the fixed point. Second, under spectral flow the chiral primaries become the Ramond ground states of the CFT. These ground states represent the microstates of a small black hole in five dimensions consisting of a D1/D5 bound state. The connection that we compute can be considered as an example of Berry's phase for the internal microstates of a supersymmetric black hole.Comment: 72 pages (60 + appendices

Predictors of irritability symptoms in mildly depressed perimenopausal women

OBJECTIVE: Irritability is a highly burdensome complaint, commonly, but not universally, linked with depressive symptoms. While increased variability in estradiol has been associated with depressive symptoms during perimenopause, more insight is needed into reproductive hormone dynamics and other factors that predispose perimenopausal women to irritable mood. METHODS: Among 50 mildly depressed perimenopausal women (mean (SD) age 48.4 (3.9) years), severity of irritability symptoms (on Symptom Questionnaire Hostility subscale, range 0-23) was assessed weekly for eight weeks, concurrent with potential predictors. Associations between these were examined using generalized estimating equating models. RESULTS: Most women (82.0%) reported having moderate to severe irritability at least once. However, the severity of irritability was highly variable from week-to-week (between-subject mean coefficient of variation [CV] 72.9% and within-subject mean CV 63.7%). In multivariate analyses, less variable serum estradiol levels (standardized beta within-person CV -0.23 95%CI [-0.32, -0.14], p \u3c 0.001), greater depression severity (0.45 [0.35, 0.56], p \u3c 0.001), younger age (-0.23, [-0.28, -0.09], p \u3c 0.001), and more frequent vasomotor symptoms (0.14 [0.05, 0.23], p=0.002) were associated with more irritability. Depression severity explained the largest portion of the variance in irritability, but still not more than 20.3%. Neither crude values, weekly change in, or variability of progesterone or FSH levels were associated with irritability. CONCLUSIONS: Irritability was highly prevalent among mildly depressed perimenopausal women. In contrast to depressive symptoms, decreased rather than increased variability in estradiol levels was associated with more irritability. This highlights that irritable mood can be disentangled from depressive symptoms in perimenopausal women and might be linked with different estradiol dynamics

Plasma androgens and the presence and course of depression in a large cohort of men

Background: Hypoandrogenic men showed a higher prevalence of major depressive disorder (MDD), which could be ascribed to overlapping symptoms such as sexual dysfunction, or additionally to core emotional symptoms such as sadness and anhedonia. We examined whether androgen levels 1) differ between men with and without MDD cross-sectionally, 2) are associated with an elevated risk for onset of MDD prospectively, and 3) associate with all individual MDD symptoms, or only with hypogonadism overlapping symptoms. Methods: In 823 men (mean age 43.5 years), baseline plasma levels of total testosterone, 5α-dihydrotestosterone (5α-DHT), and androstenedione were determined with liquid chromatography–tandem mass spectrometry, and dehydroepiandrosterone-sulphate (DHEAS) and sex hormone binding globulin with radioimmunoassay, whereas free testosterone was calculated. MDD status was assessed at baseline and after two years using structured interviews and individual MDD symptoms were self-rated at baseline, and after one and two years. Results: None of the androgen levels were associated with current or onset (incidence or recurrence) of MDD. Free testosterone was only inversely associated with interest in sex. Also, androstenedione and DHEAS were positively associated with some individual MDD symptoms, and 5α-DHT levels showed non-linear associations (both with low and high levels) with MDD symptom severity and several individual MDD symptoms. Conclusions: These results support the idea that circulating androgens synthesised by the testes are of limited clinical relevance to MDD in adult men, but levels of androstenedione, DHEAS and 5α-DHT may be associated with some individual MDD symptoms

Efficacy of combined oral contraceptives for depressive symptoms and overall symptomatology in premenstrual syndrome:pairwise and network meta-analysis of randomized trials

OBJECTIVE: Combined oral contraceptives are often considered a treatment option for women with premenstrual syndrome (PMS) or premenstrual dysphoric disorder (PMDD) also seeking contraception, but evidence for this treatment is scarce. We aimed to determine 1) the level of evidence for the efficacy of combined oral contraceptives in managing premenstrual depressive symptoms and overall premenstrual symptomatology, and 2) the comparative efficacy of combined oral contraceptives (PROSPERO registration number CRD42020205510). DATA SOURCES: We searched Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, Web of Science, PsycINFO, Emcare, and EMBASE from inception to June 3rd, 2021. STUDY ELIGIBILITY: All randomized clinical trials that evaluated efficacy of combined oral contraceptives in women with PMS or PMDD were considered eligible for inclusion in the present meta-analysis. STUDY APPRAISAL AND SYNTHESIS METHODS: A random effect Bayesian pairwise and network meta-analysis was conducted with change in premenstrual depressive symptoms and overall premenstrual symptomatology between baseline and 3 cycles as outcome. Certainty of the evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation approach. RESULTS: Of 3664 records, nine eligible trials were included that studied 1205 women with PMS or PMDD (mean age per study range: 24.6-36.5 years). The pairwise meta-analysis revealed that combined oral contraceptives were more efficacious than placebo in treating overall premenstrual symptomatology (standardized mean difference SMD [95%CrI], 0.41 [0.17, 0.67]), but not premenstrual depressive symptoms specifically (SMD [95%CrI], 0.22 [-0.06, 0.47]). However, none of the combined oral contraceptives were more effective than each other in reducing premenstrual depressive symptoms and overall premenstrual symptomatology. CONCLUSIONS: Combined oral contraceptives may improve overall premenstrual symptomatology in women with PMS or PMDD, but not premenstrual depressive symptoms. There is no evidence for one combined oral contraceptive being more efficacious than any other

ICT as an instrument for social and emotional ageing. A qualitative study with older adults with cognitive impairments

Inspired by theories from the field of social and emotional aging, we studied the use of ICTs by older adults with cognitive impairments. By means of qualitative interviews (N=30) with older adults with cognitive impairments and their relatives, we got a detailed picture of the role of ICTs in their daily lives. First, our data showed that older adults with cognitive impairments used ICTs to enhance their social and emotional wellbeing. This involved social interaction, feelings of belongingness, and engagement in hobbies and regular daily activities. Second, our research provided insight into the strategies applied when ICT use became too difficult, with a considerable role for the social network. When the network offered help upon request or proactively encouraged the older person, this increased the perception of control. This also applied to the indirect use of ICTs, when someone from the social network operated the devices. Denying the older person the use of ICTs undermined the perception of control. The findings provide insight into how the potential of ICT can be exploited for this target group. We end the paper with practical recommendations

On RG-flow and the Cosmological Constant

The AdS/CFT correspondence implies that the effective action of certain strongly coupled large $N$ gauge theories satisfy the Hamilton-Jacobi equation of 5d gravity. Using an analogy with the relativistic point particle, I construct a low energy effective action that includes the Einstein action and obeys a Callan-Symanzik-type RG-flow equation. It follows from the flow equation that under quite general conditions the Einstein equations admit a flat space-time solution, but other solutions with non-zero cosmological constant are also allowed. I discuss the geometric interpretation of this result in the context of warped compactifications.Comment: 11 pages, 1 figure, contribution to the proceedings of Strings '99, misprint correcte