71 research outputs found
Jacobi Structures in
The most general Jacobi brackets in are constructed after
solving the equations imposed by the Jacobi identity. Two classes of Jacobi
brackets were identified, according to the rank of the Jacobi structures. The
associated Hamiltonian vector fields are also constructed
Geometrical aspects of integrable systems
We review some basic theorems on integrability of Hamiltonian systems, namely
the Liouville-Arnold theorem on complete integrability, the Nekhoroshev theorem
on partial integrability and the Mishchenko-Fomenko theorem on noncommutative
integrability, and for each of them we give a version suitable for the
noncompact case. We give a possible global version of the previous local
results, under certain topological hypotheses on the base space. It turns out
that locally affine structures arise naturally in this setting.Comment: It will appear on International Journal of Geometric Methods in
Modern Physics vol.5 n.3 (May 2008) issu
Poisson Geometry in Constrained Systems
Constrained Hamiltonian systems fall into the realm of presymplectic
geometry. We show, however, that also Poisson geometry is of use in this
context.
For the case that the constraints form a closed algebra, there are two
natural Poisson manifolds associated to the system, forming a symplectic dual
pair with respect to the original, unconstrained phase space. We provide
sufficient conditions so that the reduced phase space of the constrained system
may be identified with a symplectic leaf in one of those. In the second class
case the original constrained system may be reformulated equivalently as an
abelian first class system in an extended phase space by these methods.
Inspired by the relation of the Dirac bracket of a general second class
constrained system to the original unconstrained phase space, we address the
question of whether a regular Poisson manifold permits a leafwise symplectic
embedding into a symplectic manifold. Necessary and sufficient for this is the
vanishing of the characteristic form-class of the Poisson tensor, a certain
element of the third relative cohomology.Comment: 41 pages, more detailed abstract in paper; v2: minor corrections and
an additional referenc
Effect of corticotropin treatment in vivo on the synthesis of a specific adrenal cytosolic protein. Characterization by dual-labelling technique and polyacrylamide-gel electrophoresis
Integration of Dirac-Jacobi structures
We study precontact groupoids whose infinitesimal counterparts are
Dirac-Jacobi structures. These geometric objects generalize contact groupoids.
We also explain the relationship between precontact groupoids and homogeneous
presymplectic groupoids. Finally, we present some examples of precontact
groupoids.Comment: 10 pages. Brief changes in the introduction. References update
Adoptive immunotherapy monitored by micro-MRI in experimental colorectal liver metastasis
In this study we used the colon carcinoma DHDK12 cell line and generated single metastasis after subcapsular injection in BDIX rats as an experimental tumor model. The aim of the work was to set up in vitro experimental conditions to prepare immune effector cells and in vivo conditions for monitoring the effects of such cells injected as adoptive immunotherapy. Dendritic cells can process tumor cell antigens, induce a T-cell response and be used ex vivo to prepare activated lymphocytes. Lymphocytes were harvested from mesenteric lymph nodes and cocultured with bone marrow-derived autologous dendritic cells previously loaded with irradiated tumor cells. In vitro, the coculture: 1) induced the proliferation of lymphocytes, 2) expanded a preferential subpopulation of T CD8 lymphocytes, and 3) was in favor of lymphocyte cytotoxic activity against the DHDK12 tumor cell line. Activated lymphocytes were injected in the tumor-bearing rat portal vein. Parameters could be set to monitor tumor volume by micro MRI. This monitoring before and after treatment and immunohistochemical examinations revealed that: 1) micro MRI is an appropriate tool to survey metastasis growth in rat, 2) injected lymphocytes increase lesional infiltration with T CD8 cells even 15 days after treatment, 3) a dose of 50 millions lymphocytes is not sufficient to act on the course of the tumor
Is magnetic resonance imaging texture analysis a useful tool for cell therapy in vivo monitoring?
Assessment of anti-tumor treatment efficiency is usually done by measuring tumor size. Treatment may however induce changes in the tumor other than tumor size. Magnetic Resonance Imaging Texture Analysis (MRI-TA) is presently used to follow activated lymphocyte cell therapy. We used a 7T microimager to acquire high-resolution MR images of an experimental liver metastasis from colon carcinoma in rats treated (n = 4) or not (n = 3) with a cell therapy product. MRI-TA was then performed with Linear Discriminant Analysis and showed: i) a significant variation of tumor texture with tumor growth and ii) a significant modification in the texture of tumors treated with activated lymphocytes compared with untreated tumors. T2-weighted images or volume calculation did not evidence any difference. MRI-TA appears as a promising method for early detection and follow-up of response to cell therapy
Poisson-Jacobi reduction of homogeneous tensors
The notion of homogeneous tensors is discussed. We show that there is a
one-to-one correspondence between multivector fields on a manifold ,
homogeneous with respect to a vector field on , and first-order
polydifferential operators on a closed submanifold of codimension 1 such
that is transversal to . This correspondence relates the
Schouten-Nijenhuis bracket of multivector fields on to the Schouten-Jacobi
bracket of first-order polydifferential operators on and generalizes the
Poissonization of Jacobi manifolds. Actually, it can be viewed as a
super-Poissonization. This procedure of passing from a homogeneous multivector
field to a first-order polydifferential operator can be also understood as a
sort of reduction; in the standard case -- a half of a Poisson reduction. A
dual version of the above correspondence yields in particular the
correspondence between -homogeneous symplectic structures on and
contact structures on .Comment: 19 pages, minor corrections, final version to appear in J. Phys. A:
Math. Ge
The graded Jacobi algebras and (co)homology
Jacobi algebroids (i.e. `Jacobi versions' of Lie algebroids) are studied in
the context of graded Jacobi brackets on graded commutative algebras. This
unifies varios concepts of graded Lie structures in geometry and physics. A
method of describing such structures by classical Lie algebroids via certain
gauging (in the spirit of E.Witten's gauging of exterior derivative) is
developed. One constructs a corresponding Cartan differential calculus (graded
commutative one) in a natural manner. This, in turn, gives canonical generating
operators for triangular Jacobi algebroids. One gets, in particular, the
Lichnerowicz-Jacobi homology operators associated with classical Jacobi
structures. Courant-Jacobi brackets are obtained in a similar way and use to
define an abstract notion of a Courant-Jacobi algebroid and Dirac-Jacobi
structure. All this offers a new flavour in understanding the
Batalin-Vilkovisky formalism.Comment: 20 pages, a few typos corrected; final version to be published in J.
Phys. A: Math. Ge
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