240 research outputs found
Stomatal Movements Associated With Potassium Fluxes
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141735/1/ajb212347.pd
Trichomes Of Cannabis Sativa L. (Cannabaceae)
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142132/1/ajb211846.pd
Detection Of Silica In Plants
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141518/1/ajb207909.pd
Ecological Adaptations Of Salt Marsh Grass, Distichlis Spicata (Gramineae), And Environmental Factors Affecting Its Growth And Distribution
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142123/1/ajb211851.pd
Food of some Demersal fishes from the trawl Grounds off Cochin
The food habits of seven commonly caught demersal fishes from the Cochin region,
namely, Platycepha'us maculipinna, Pseudosciaena sina, Otolithus argenteus, Lactarius
lactarius, Saurida tiimbil, Trichiurus tepturus and Nemipterus faponicus have been
studied during the period from February 1965 to October 1967.
It is seer, that these fishes could be grouped into three categories on the basis of
their food preferences. One group consisting of L. lactarius, T. lepturus and
S.tumbilh largely piscivorous. The second category feeds on a variety of crustaceans
and also fish. This includes P. maculipinna, P. sina and O. argenteus. The third
category represented by the thread-fin bream A'. Japonicus consumes small crustaceans
dominated by amphipods. Polychaetes and echiuroids form a significant proportion
of the food of these fishes.
Smaller commercial penaeid prawns like Parapenaeopsis stylifera and Metapenaeus
dobsoni were eaten liy majority of the species studied. They were found in significant
quantities in the focd of O. argenteus and to a lesser extent in P. sina, P. maculipinna
and T. lepturus
Randomized multicentre pilot study of sacubitril/valsartan versus irbesartan in patients with chronic kidney disease: United Kingdom Heart and Renal Protection (HARP)- III—rationale, trial design and baseline data
BACKGROUND:
Patients with chronic kidney disease (CKD) are at risk of progression to end-stage renal disease and cardiovascular disease. Data from other populations and animal experiments suggest that neprilysin inhibition (which augments the natriuretic peptide system) may reduce these risks, but clinical trials among patients with CKD are required to test this hypothesis.
METHODS:
UK Heart and Renal Protection III (HARP-III) is a multicentre, double-blind, randomized controlled trial comparing sacubitril/valsartan 97/103 mg two times daily (an angiotensin receptor-neprilysin inhibitor) with irbesartan 300 mg one time daily among 414 patients with CKD. Patients ≥18 years of age with an estimated glomerular filtration rate (eGFR) of ≥45 but <60 mL/min/1.73 m2 and urine albumin:creatinine ratio (uACR) >20 mg/mmol or eGFR ≥20 but <45 mL/min/1.73 m2 (regardless of uACR) were invited to be screened. Following a 4- to 7-week pre-randomization single-blind placebo run-in phase (during which any current renin-angiotensin system inhibitors were stopped), willing and eligible participants were randomly assigned either sacubitril/valsartan or irbesartan and followed-up for 12 months. The primary aim was to compare the effects of sacubitril/valsartan and irbesartan on measured GFR after 12 months of therapy. Important secondary outcomes include effects on albuminuria, change in eGFR over time and the safety and tolerability of sacubitril/valsartan in CKD.
RESULTS:
Between November 2014 and January 2016, 620 patients attended a screening visit and 566 (91%) entered the pre-randomization run-in phase. Of these, 414 (73%) participants were randomized (mean age 63 years; 72% male). The mean eGFR was 34.0 mL/min/1.73 m2 and the median uACR was 58.5 mg/mmol.
CONCLUSIONS:
UK HARP-III will provide important information on the short-term effects of sacubitril/valsartan on renal function, tolerability and safety among patients with CKD
Exploratory trawl fishing and ground fish resources along the Kerala coast and adjacent waters
The paper deals with exploratory fishing operations mainly trawling, conducted along Kerj^a Coast and
adjacent waters since 1908. Early operations prior to 1950 demonstrated tlie occurrence of rich grounds
for percoid fishes in the Cape Comorin area and good hand-line fkhiiig grounds off South Kerala Coast.
Bull trawling in the Cannanore-Cape Comorin region by the vessels of the Deep Sea Fishing, Station
of the Government of India showed that elasmobranchs and miscellaneous fish comprising small sciaenids,
lizard fishes, flatheads, etc., were common for the area with a dominant catfish element in the Cannanoi«-
Calicut sector, perch element south of AUeppey including Cape Comorin grounds and a transitional middle
sector having a few catfishes and perches.
Inshore otter trawl operations with medium-sized boats were increasingly carried out by the lndo>.Norwegian
Project, Deep Sea Fishing Station and private agencies mainly centred around Coehin during; the last
decade. Deep Sea Fishing Station operations in the region revealed a composition of about SO % miscellaaeous
fish, 20-35% prawns, 8-14% Nemipterus japonicus, 6-14% elasmobranchs and 1-3% Laeiarius faciariiu.
These operations showed the area between Calicut and Alleppey to be more productive, those off river
and bar mouths yielding good quantity of prawns. The catch rate of prawns and fish increased steadily
around Cochin from 1957 to 1961 and since then showed a slight decline. The picture is indicative of excessive
fishing pressure over a limited area. This points to the necessity for even dispersal of fishing effort.
Indo-Norwegian Project hand-line fishing operations provided considerable information regarding the
'Kalava' (Epinephelus spp.) resources of the rocky grounds on the continental shelf usually lying in 70-110 m
depth zone off Kerala Coast.
The occurrence of a variety of deep sea prawns, densely shoaling bathypelagic fishes like Cubiceps uatalensis,
Chlorophthatmus spp., Antigonia spp., mid-water concentrations of balistids etc. have been found out
along the Kerala Coast mainly by the fishing operations of the Indo-Norwegian Project. These as well as
the "Kalava" resources could be better exploited with increased effort
Hormone trafficking. A case study of growth regulator dynamics
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74950/1/j.1399-3054.1993.tb01811.x.pd
Randomized multicentre pilot study of sacubitril/valsartan versus irbesartan in patients with chronic kidney disease: United Kingdom Heart and Renal Protection (HARP)- III-rationale, trial design and baseline data
Background
Patients with chronic kidney disease (CKD) are at risk of progression to end-stage renal disease and cardiovascular disease. Data from other populations and animal experiments suggest that neprilysin inhibition (which augments the natriuretic peptide system) may reduce these risks, but clinical trials among patients with CKD are required to test this hypothesis.
Methods
UK Heart and Renal Protection III (HARP-III) is a multicentre, double-blind, randomized controlled trial comparing sacubitril/valsartan 97/103 mg two times daily (an angiotensin receptor–neprilysin inhibitor) with irbesartan 300 mg one time daily among 414 patients with CKD. Patients ≥18 years of age with an estimated glomerular filtration rate (eGFR) of ≥45 but 20 mg/mmol or eGFR ≥20 but <45 mL/min/1.73 m2 (regardless of uACR) were invited to be screened. Following a 4- to 7-week pre-randomization single-blind placebo run-in phase (during which any current renin–angiotensin system inhibitors were stopped), willing and eligible participants were randomly assigned either sacubitril/valsartan or irbesartan and followed-up for 12 months. The primary aim was to compare the effects of sacubitril/valsartan and irbesartan on measured GFR after 12 months of therapy. Important secondary outcomes include effects on albuminuria, change in eGFR over time and the safety and tolerability of sacubitril/valsartan in CKD.
Results
Between November 2014 and January 2016, 620 patients attended a screening visit and 566 (91%) entered the pre-randomization run-in phase. Of these, 414 (73%) participants were randomized (mean age 63 years; 72% male). The mean eGFR was 34.0 mL/min/1.73 m2 and the median uACR was 58.5 mg/mmol.
Conclusions
UK HARP-III will provide important information on the short-term effects of sacubitril/valsartan on renal function, tolerability and safety among patients with CKD
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