Impact of clinical phenotypes on management and outcomes in European atrial fibrillation patients: a report from the ESC-EHRA EURObservational Research Programme in AF (EORP-AF) General Long-Term Registry

Background: Epidemiological studies in atrial fibrillation (AF) illustrate that clinical complexity increase the risk of major adverse outcomes. We aimed to describe European AF patients\u2019 clinical phenotypes and analyse the differential clinical course. Methods: We performed a hierarchical cluster analysis based on Ward\u2019s Method and Squared Euclidean Distance using 22 clinical binary variables, identifying the optimal number of clusters. We investigated differences in clinical management, use of healthcare resources and outcomes in a cohort of European AF patients from a Europe-wide observational registry. Results: A total of 9363 were available for this analysis. We identified three clusters: Cluster 1 (n = 3634; 38.8%) characterized by older patients and prevalent non-cardiac comorbidities; Cluster 2 (n = 2774; 29.6%) characterized by younger patients with low prevalence of comorbidities; Cluster 3 (n = 2955;31.6%) characterized by patients\u2019 prevalent cardiovascular risk factors/comorbidities. Over a mean follow-up of 22.5 months, Cluster 3 had the highest rate of cardiovascular events, all-cause death, and the composite outcome (combining the previous two) compared to Cluster 1 and Cluster 2 (all P <.001). An adjusted Cox regression showed that compared to Cluster 2, Cluster 3 (hazard ratio (HR) 2.87, 95% confidence interval (CI) 2.27\u20133.62; HR 3.42, 95%CI 2.72\u20134.31; HR 2.79, 95%CI 2.32\u20133.35), and Cluster 1 (HR 1.88, 95%CI 1.48\u20132.38; HR 2.50, 95%CI 1.98\u20133.15; HR 2.09, 95%CI 1.74\u20132.51) reported a higher risk for the three outcomes respectively. Conclusions: In European AF patients, three main clusters were identified, differentiated by differential presence of comorbidities. Both non-cardiac and cardiac comorbidities clusters were found to be associated with an increased risk of major adverse outcomes

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Not AvailableOut of about 32,600 fishes found globally, 2,553 species have been reported from the Indian subcontinent in addition to about 500 introduced species. Six drainage systems and their tributaries are the natural habitat of the entire freshwater fish genetic resources (about 877 species). The Western Ghats and North-eastern Region are the globally recognized two biodiversity hotspots as these are the home of many endemic fish species which are exclusively confined to these areas. During exploration, identification and documentation of fish diversity by various authors in different geographic regions, 62 new species belonging to 4 Orders, 21 Families and 31 Genera have been discovered from the Indian region during 2010-13. Of these, 7 species were reported in 2010, 14 species in 2011, 24 species in 2012 and 16 species in 2013, 54 endemic species have been described from the freshwater system and 7 species from the marine ecosystem of Andaman and Tuticorin (Bay of Bengal), Arabian Sea and south Indian coast of the Indian Ocean. As far as the two biodiversity hot spots are concerned, 37 new species have been discovered from North-eastern region and 16 species from Western Ghats. The data thus collected and analysed indicate area-wise species richness and possibilities for more discoveries in future.Not Availabl

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Not AvailableCumin is an important seed spice and cash crop of arid and semi-arid regions of Rajasthan under limited irrigation facilities during Rabi season. The farmers of this district are trying to adopt the improved varieties andi.scientific technologies, however many of them still doing the farming with available local varieties and conventional practices. The present investigation was conducted in selected villages of Jodhpur district to study the existing adoption level of the farmers regarding improved cumin cultivation practices and to study the impact of front line demonstrations on cumin production technology. It was found from the study that 76.48 and 69.12 percent farmers, respectively has fully adopted the field preparation and time of sowing and high yielding varieties.Whereas,only 27.95 percent farmers fully adopted the recommended seed rate and spacing. The 48.10 percent increase inyield under FLDs was recorded over farmer's practice. The overallaverage extensiongap and technology gap was observed 243 kg/haand 549 kg/ha, respectively. The technology index was 42.25 with benefit-cost ratio of FLDs was 2.48.Not Availabl

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Not Availablen order to evaluate the efficacy of ovaprim over the pituitary glands (PG) in induced breeding of Indian major carps under agroclimatic conditions of Uttar Pradesh, matured brooders of Catla catla, Labeo rohita and Cirrhinus mrigala were administered intramuscularly (i. m.) with ovaprim (single injection) at the dosage of 0.25-0.60 ml/kg. Control fishes received i. m. injections of carp PG - two split doses (3 & 8 mg / kg) for females and single dose (3-4 mg / kg) for males. Spawning response of rohu was complete both with ovaprim (0.35/kg) and PG. The mrigal responded even to 0.25 ml / kg ovaprim. Even catla, the species slightly difficult to breed in this area, also responded fairly well with the drug (0.60 ml / kg). The general conditions of the fertilized eggs during hatching also remained better with ovaprim. The breeding response of the Indian major carps to ovaprim shows the efficacy and potential application of the drug over PG in the agroclimatic conditions of Uttar Pradesh.Not Availabl

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Not AvailableAn on-farm trial (OFT) was conducted at three farmer's field with three treatments in Lunawas Khara village of Luni Panchayat Samiti in Jodhpur district of Rajasthan during rabi 2011-12 to 2012-13 to assess the impact of line sowing in improving the productivity of cumin (variety GC-4). Technological intervention of line sowing was compared with recommended practice and existing farmers practice for yield maximisation and economic returns from cumin under irrigated condition on sandy loam soil. Results of the study revealed that yield attributes in terms of branches plant', umbels plant', umblets plant' and grain yield plant' increased by 43, 78, 51, and 77%, respectively with technological intervention of line sowing over farmers practice. The grain yield was increased from 458 to 810 kg had during 2011-12 and 502 to 888 kg had during 2012-13 with the technological intervention. The mean grain yield was recorded 77% higher than the farmers practice (480 kg had).Not Availabl

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