17 research outputs found
Genetic alterations in lymphoblastic leukaemia / lymphoma â a practical guide to WHO HAEM5
\ua9 2024 the author(s), published by De Gruyter.We present a practical guide for analyzing the genetic aspects of lymphoblastic leukaemia/lymphoma according to the 5th edition of the World Health Organization (WHO) classification of haematolymphoid neoplasms (WHO-HAEM5) issued in 2024. The WHO-HAEM5 acknowledges the increasing importance of genetics in the diagnosis of lymphoid neoplasia. Classification is based on the established genetic subtypes according to cell lineage, with precursor cell neoplasms followed by mature malignancies. This guide describes those genetic abnormalities in acute precursor B- and T-cell neoplasms required for risk stratification, and for treatment, providing diagnostic algorithms under the headings of âessentialâ and âdesirableâ diagnostic criteria
Novel Bradykinin Analogues Modified in the N-Terminal Part of the Molecule with a Variety of Acyl Substituents
In the current work we present some pharmacological characteristics of ten new analogues of bradykinin (ArgâProâProâGlyâPheâSerâProâPheâArg) modified in the N-terminal part of the molecule with a variety of acyl substituents. Of the many acylating agents used previously with B2 receptor antagonists, the following residues were chosen: 1-adamantaneacetic acid (Aaa), 1-adamantanecarboxylic acid (Aca), 4-tert-butylbenzoic acid (t-Bba), 4-aminobenzoic acid (Aba), 12-aminododecanoic acid (Adc), succinic acid (Sua), 4-hydroxybenzoic acid, 4-hydroxy-3-methoxybenzoic acid, 3-(4-hydroxyphenyl)propionic acid and 6-hydroxy-2-naphthoic acid. Biological activity of the compounds was assessed in the in vivo rat blood pressure test and the in vitro rat uterus test. Surprisingly, N-terminal substitution of the bradykinin peptide chain itself with aforementioned groups resulted in antagonists of bradykinin in the pressor test and suppressed agonistic potency in the uterotonic test. These interesting findings need further studies as they can be helpful for designing more potent B2 receptor blockers
Implementation of the standard strategy for identification of Ig/TCR targets for minimal residual disease diagnostics in B-cell precursor ALL pediatric patients: Polish experience
Minimal residual disease detection in Tunisian B-acute lymphoblastic leukemia based on immunoglobulin gene rearrangements
Significance of genetic variations in developmental enamel defects of primary dentition in Polish children
Influence of bioremediation stimulators in soil on development of oat seedlings (Avena sativa) and their aminopeptidase activity / WpĆyw pozostaĆoĆci substancji ropopochodnych w glebie na rozwĂłj owsa i aktywnoĆÄ aminopeptydazowÄ
The selection of bioremediation techniques is important for purification of contaminated soil for agricultural use. Studies on soil contaminated with petroleum substances have indicated that the applied method of remediation has a bigger impact on the development of oat seedlings than the level of contamination. A yeast inoculum appeared to be a technique which was the friendliest to vegetation of oat.DobĂłr technik bioremediacji jest bardzo waĆŒny w oczyszczaniu gleby skaĆŒonej substancjami ropopochodnymi, ktĂłra ma byÄ wykorzystywanej rolniczo. Prezentowane wyniki wskazujÄ
, ĆŒe na rozwĂłj siewek owsa wiÄkszy wpĆyw ma stosowana metoda bioremediacji niĆŒ poziom zanieczyszczenia wÄglowodorami. Z zastosowanych technik najbardziej przyjazne dla wegetacji owsa byĆy te, w ktĂłrych wykorzystywano szczepionkÄ droĆŒdĆŒowÄ
P332: MIR-625-5P IS NOVEL CANDIDATE ONCOMIR IN T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA IMPLICATED IN REGULATION OF APOPTOSIS VIA REPRESSION OF HARAKIRI
WpĆyw pozostaĆoĆci substancji ropopochodnych w glebie na rozwĂłj owsa i aktywnoĆÄ aminopeptydazowÄ
The selection of bioremediation techniques is important for purification of contaminated soil for agricultural use. Studies on soil contaminated with petroleum substances have indicated that the applied method of remediation has a bigger impact on the development of oat seedlings than the level of contamination. A yeast inoculum appeared to be a technique which was the friendliest to vegetation of oat.DobĂłr technik bioremediacji jest bardzo waĆŒny w oczyszczaniu gleby skaĆŒonej substancjami ropopochodnymi, ktĂłra ma byÄ wykorzystywanej rolniczo. Prezentowane wyniki wskazujÄ
, ĆŒe na rozwĂłj siewek owsa wiÄkszy wpĆyw ma stosowana metoda bioremediacji niĆŒ poziom zanieczyszczenia wÄglowodorami. Z zastosowanych technik najbardziej przyjazne dla wegetacji owsa byĆy te, w ktĂłrych wykorzystywano szczepionkÄ droĆŒdĆŒowÄ