2,331 research outputs found
A retrospective review of factors associated with response to phototherapy and PUVA for atopic eczema
Irradiance, as well as body site and timing of readings, is important in determining ultraviolet A minimal erythemal dose. (Response to Gambichler et al. July BJD)
Lack of phototoxicity potential with delafloxacin in healthy male and female subjects:comparison to lomefloxacin
Non-commutative fermion mass matrix and gravity
The first part is an introductory description of a small cross-section of the
literature on algebraic methods in non-perturbative quantum gravity with a
specific focus on viewing algebra as a laboratory in which to deepen
understanding of the nature of geometry. This helps to set the context for the
second part, in which we describe a new algebraic characterisation of the Dirac
operator in non-commutative geometry and then use it in a calculation on the
form of the fermion mass matrix. Assimilating and building on the various ideas
described in the first part, the final part consists of an outline of a
speculative perspective on (non-commutative) quantum spectral gravity. This is
the second of a pair of papers so far on this project.Comment: To appear in Int. J. Mod. Phys. A Previous title: An outlook on
quantum gravity from an algebraic perspective. 39 pages, 1 xy-pic figure,
LaTex Reasons for new version: added references, change of title and some
comments more up-to-dat
Quantitative analysis of topical treatments in atopic dermatitis:unexpectedly low use of emollients and strong correlation of topical corticosteroid use both with depression and concurrent asthma
Narrowband ultraviolet B phototherapy is associated with a reduction in topical corticosteroid and clinical improvement in atopic dermatitis:a historical inception cohort study
Lessons from Expert Focus Groups on how to Better Support Adults with Mild Intellectual Disabilities to Engage in Co-Design
Co-design techniques generally rely upon higher-order cognitive skills, such as abstraction and creativity, meaning they may be inaccessible to people with intellectual disabilities (ID). Consequently, investigators must adjust the methods employed throughout their studies to ensure the complex needs of people with ID are appropriately catered to. Yet, there are a lack of guidelines to support researchers in this process, with previous literature often neglecting to discuss the decisions made during the development of their study protocols. We propose a new procedure to overcome this lack of support, by utilizing the knowledge of âexpertsâ in ID to design a more accessible workshop for the target population. 12 experts across two focus groups were successful in identifying accessibility barriers throughout a set of typical early co-design activities. Recommendations to overcome these barriers are discussed along with lessons on how to better support people with ID to engage in co-design
An overview of the cutaneous porphyrias
This is an overview of the cutaneous porphyrias. It is a narrative review based on the published literature and my personal experience; it is not based on a formal systematic search of the literature. The cutaneous porphyrias are a diverse group of conditions due to inherited or acquired enzyme defects in the porphyrinâhaem biosynthetic pathway. All the cutaneous porphyrias can have (either as a consequence of the porphyria or as part of the cause of the porphyria) involvement of other organs as well as the skin. The single commonest cutaneous porphyria in most parts of the world is acquired porphyria cutanea tarda, which is usually due to chronic liver disease and liver iron overload. The next most common cutaneous porphyria, erythropoietic protoporphyria, is an inherited disorder in which the accumulation of bile-excreted protoporphyrin can cause gallstones and, rarely, liver disease. Some of the porphyrias that cause blistering (usually bullae) and fragility (clinically and histologically identical to porphyria cutanea tarda) can also be associated with acute neurovisceral porphyria attacks, particularly variegate porphyria and hereditary coproporphyria. Management of porphyria cutanea tarda mainly consists of visible-light photoprotection measures while awaiting the effects of treating the underlying liver disease (if possible) and treatments to reduce serum iron and porphyrin levels. In erythropoietic protoporphyria, the underlying cause can be resolved only with a bone marrow transplant (which is rarely justifiable in this condition), so management consists particularly of visible-light photoprotection and, in some countries, narrowband ultraviolet B phototherapy. Afamelanotide is a promising and newly available treatment for erythropoietic protoporphyria and has been approved in Europe since 2014
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