27 research outputs found

    Formation and emission of reactive chlorine in indoor air

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    Chlorine atoms are powerful atmospheric oxidants known to degrade air quality. Despite much focus, a direct measurement technique does not exist. Instead, chlorine atom precursors are used as proxies to study chlorine atom chemistry. Reactions of precursors resulting in chlorine atoms studied in outdoor environments are also possible indoors. Daily household activities, especially those involving chlorinated cleaning products, are suspected to contribute to indoor chlorine atom chemistry. Indoor air studies are hindered by sampling techniques, as few appropriate instruments exist. A common atmospheric measurement technique was evaluated while monitoring gas and particulate phase species emitted during indoor bleach use. This instrument collects a non-selective gaseous and a particulate chloride sample. Recent advances in indoor instrumentation allow for selective measurement of chlorine atom precursor, hydrogen chloride (HCl), using a cavity-ring down spectroscopy instrument. Present ubiquitously outdoors, atmospheric HCl is a result of direct emission and secondary production. Previous measurements of HCl indoors are rare and have been limited to non-residential buildings using integrated sampling. This sampling strategy does not provide the source of HCl emissions. In order to better understand sources of HCl indoors, real-time gas-phase mixing ratios of HCl during typical household activities were monitored such as floor exposure to bleach, detergent use in household dishwashers, and cooking events. Based on calculated rates of chlorine atom precursors, both photolysis and direct emission could be contributing to elevated HCl levels indoors. This work presents insights regarding HCl production and the influence of household activities on indoor air quality

    Formation and emission of hydrogen chloride in indoor air

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    To improve our understanding of chlorine chemistry indoors, reactive chlorine species such as hydrogen chloride (HCl) must be analyzed using fast time-response measurement techniques. Although well studied outdoors, sources of HCl indoors are unknown. In this study, mixing ratios of gaseous HCl were measured at 0.5 Hz in the indoor environment using a cavity ring-down spectroscopy (CRDS) instrument. The CRDS measurement rate provides a major advance in observational capability compared to other established techniques. Measurements of HCl were performed during three types of household activities: (1) floor exposure to bleach, (2) chlorinated and non-chlorinated detergent use in household dishwashers, and (3) cooking events. Surface application of bleach resulted in a reproducible increase of 0.1 ppbv in the affected room. Emissions of HCl from automated dishwashers were observed only when chlorinated detergents were used, with additional HCl emitted during the drying cycle. Increased mixing ratios of HCl were also observed during meal preparation on an electric element stovetop. These observations of HCl derived from household activities indicate either direct emission or secondary production of HCl via chlorine atoms is possible. Calculations of photolysis rate constants of chlorine atom precursors provide evidence that photolysis may contribute to indoor HCl levels

    Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

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    Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

    Measurements of top-quark pair differential cross-sections in the eμe\mu channel in pppp collisions at s=13\sqrt{s} = 13 TeV using the ATLAS detector

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    Measurement of the W boson polarisation in ttˉt\bar{t} events from pp collisions at s\sqrt{s} = 8 TeV in the lepton + jets channel with ATLAS

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    Measurement of the charge asymmetry in top-quark pair production in the lepton-plus-jets final state in pp collision data at s=8TeV\sqrt{s}=8\,\mathrm TeV{} with the ATLAS detector

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    Search for single production of vector-like quarks decaying into Wb in pp collisions at s=8\sqrt{s} = 8 TeV with the ATLAS detector

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    Measurement of the bbb\overline{b} dijet cross section in pp collisions at s=7\sqrt{s} = 7 TeV with the ATLAS detector

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    Charged-particle distributions at low transverse momentum in s=13\sqrt{s} = 13 TeV pppp interactions measured with the ATLAS detector at the LHC

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    Search for dark matter in association with a Higgs boson decaying to bb-quarks in pppp collisions at s=13\sqrt s=13 TeV with the ATLAS detector

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