Caracterización molecular y biológica del virus de la rabia que circula en zorrillos de México enfocado a la variante del gen de la fosfoproteína (P)

The objective of this work was to characterize molecularly rabies viruses from Mexican skunks, by comparison of a portion of the viral P gene sequence with corresponding regions from other skunk-adapted rabies virus variants and with other genotype 1 rabies viruses that circulate in the Americas. Furthermore, incubation period and histopathologic lesions after virus inoculation by the intra-cerebral route in mice was characterized. According to the results of phylogenetic studies the Mexican skunk strains (Antigenic Variant (AV) 8 and AV10) are evolutionarily quite distinct. The AV10 isolate from South Baja California is quite closely related to the viruses that circulate in Californian skunks, while the AV8 isolate from San Luis Potosí was most closely related to the South central skunk strain that circulates in southern states such as Texas. These variations were reflected in some biological properties of both strains in mice.El objetivo de este estudio fue la caracterización molecular y biológica del virus de la rabia en zorrillos de México, comparando una porción de la secuencia viral del gen P, con regiones correspondientes de variantes de virus rábico adaptadas en zorrillos y pertenecientes al genotipo 1 (virus de la rabia "clásica"), que circulan en América. Como parte de la caracterización biológica se incluyó el periodo de incubación y las lesiones histopatológicas después de la inoculación del virus por ví­a intracerebral en ratones. De acuerdo a los resultados de estudios filogenéticos, las cepas de zorrillo mexicano (variante antigénica (AV8 y AV10) son muy distintas en cuanto a su evolución. El aislado AV10 de Baja California Sur está muy relacionado con los virus que circulan en zorrillos de California, mientras que el aislado AV8 de San Luis Potosí­ tuvo mayor relación con la cepa del zorrillo del Centro/Sur que circula en los estados del sur, como Texas. Estas variantes se reflejaron en algunas propiedades biológicas de ambas cepas en ratones

Teacher induction: personal intelligence and the mentoring relationship

This article is aimed at probationer teachers in Scotland, their induction supporters, and all those with a responsibility for their support and professional development. It argues that the induction process is not merely a mechanistic one, supported only by systems in schools, local authorities and the General Teaching Council for Scotland (GTCS), but a more complex process where the relationship between the new teacher and the supporter is central to its success. In particular, the characteristics and skills of the induction supporter in relation to giving feedback are influential. This applies to feedback in all its forms – formative and summative, formal and informal. The ability of the probationer to handle that feedback and to be proactive in the process is also important