Radiation produces differential changes in cytokine profiles in radiation lung fibrosis sensitive and resistant mice

<p>Abstract</p> <p>Background</p> <p>Recent research has supported that a variety of cytokines play important roles during radiation-induced lung toxicity. The present study is designed to investigate the differences in early cytokine induction after radiation in sensitive (C57BL/6) and resistant mice (C3H).</p> <p>Results</p> <p>Twenty-two cytokines in the lung tissue homogenates, bronchial lavage (BAL) fluids, and serum from 3, 6, 12, 24 hrs to 1 week after 12 Gy whole lung irradiation were profiled using a microsphere-based multiplexed cytokine assay. The majority of cytokines had similar baseline levels in C57BL/6 and C3H mice, but differed significantly after radiation. Many, including granulocyte colony-stimulating factor (G-CSF), interleukin-6 (IL-6), and keratinocyte-derived chemokine (KC) were elevated significantly in specimens from both strains. They usually peaked at about 3–6 hrs in C57BL/6 and 6–12 hrs in C3H. At 6 hrs in lung tissue, G-CSF, IL-6, and KC increased 6, 8, and 11 fold in C57BL/6 mice, 4, 3, and 3 fold in the C3H mice, respectively. IL-6 was 10-fold higher at 6 hrs in the C57BL/6 BAL fluid than the C3H BAL fluid. MCP-1, IP-10, and IL-1α also showed some differences between strains in the lung tissue and/or serum. For the same cytokine and within the same strain of mice, there were significant linear correlations between lung tissue and BAL fluid levels (R²ranged 0.46–0.99) and between serum and tissue (R²ranged 0.56–0.98).</p> <p>Conclusion</p> <p>Radiation induced earlier and greater temporal changes in multiple cytokines in the pulmonary fibrosis sensitive mice. Positive correlation between serum and tissue levels suggests that blood may be used as a surrogate marker for tissue.</p

Vortex Dynamics in Selfdual Maxwell-Higgs Systems with Uniform Background Electric Charge Density

We introduce selfdual Maxwell-Higgs systems with uniform background electric charge density and show that the selfdual equations satisfied by topological vortices can be reduced to the original Bogomol'nyi equations without any background. These vortices are shown to carry no spin but to feel the Magnus force due to the shielding charge carried by the Higgs field. We also study the dynamics of slowly moving vortices and show that the spin-statistics theorem holds to our vortices.Comment: 24 pages + 2 figures ( not included), Cu-TP-611, IASSNS-HEP-93/33, NSF-ITP-93-13

Geometric Laws of Vortex Quantum Tunneling

In the semiclassical domain the exponent of vortex quantum tunneling is dominated by a volume which is associated with the path the vortex line traces out during its escape from the metastable well. We explicitly show the influence of geometrical quantities on this volume by describing point vortex motion in the presence of an ellipse. It is argued that for the semiclassical description to hold the introduction of an additional geometric constraint, the distance of closest approach, is required. This constraint implies that the semiclassical description of vortex nucleation by tunneling at a boundary is in general not possible. Geometry dependence of the tunneling volume provides a means to verify experimental observation of vortex quantum tunneling in the superfluid Helium II.Comment: 4 pages, 2 figures, revised version to appear in Phys. Rev.

Boundary of two mixed Bose-Einstein condensates

The boundary of two mixed Bose-Einstein condensates interacting repulsively was considered in the case of spatial separation at zero temperature. Analytical expressions for density distribution of condensates were obtained by solving two coupled nonlinear Gross-Pitaevskii equations in cases corresponding weak and strong separation. These expressions allow to consider excitation spectrum of a particle confined in the vicinity of the boundary as well as surface waves associated with surface tension.Comment: 6 pages, 3 figures, submitted to Phys.Rev.

Quantum Nucleation of Vortex String Loops

We investigate quantum nucleation of vortex string loops in the relativistic quantum field theory of a complex scalar field by using the Euclidean path integral. Our initial metastable homogeneous field dominated by the $O(3)$ symmetric bounce solution. The nucleation rate and the critical vortex loop size are obtained approximately. Gradually the initial current will be reduced to zero as the induced current inside vortex loops is opposite to the initial current. We also discuss a similar process in Maxwell-Higgs systems and possible physical implications.Comment: phyzzx.tex, 13 pages: A correction to the final state of the nucleation of local vortex string

Spin domain formation in spinor Bose-Einstein condensation

The spatial structure of the spinor Bose-Einstein condensates with the spin degrees of freedom is analyzed based on the generalized Gross-Pitaevskii equation (GP) in the light of the present spin domain experiment on m_F=\pm 1, and 0 of the hyperfine state F=1 of ^{23}Na atom gases. The GP solutions in three- and one-spatial dimensional cases reproduce the observed spin domain structures, revealing the length scale associated with the existence of the weak interaction of the spin-spin channel, other than the ordinary coherence length related to the density-density channel. The obtained domain structure in GP is compared with the result in Thomas-Fermi approximation. The former solution is found to better describe the observed features than the latter.Comment: 9 pages, 14 figure

Zero-temperature phase diagram of binary boson-fermion mixtures

We calculate the phase diagram for dilute mixtures of bosons and fermions at zero temperature. The linear stability conditions are derived and related to the effective boson-induced interaction between the fermions. We show that in equilibrium there are three possibilities: a) a single uniform phase, b) a purely fermionic phase coexisting with a purely bosonic one and c) a purely fermionic phase coexisting with a mixed phase.Comment: 8 pages, revtex, 3 postscript figures; NORDITA-1999/71 C

Topological Landau-Ginzburg Theory for Vortices in Superfluid 4^4He

We propose a new Landau-Ginzburg theory for arbitrarily shaped vortex strings in superfluid $^4$He. The theory contains a topological term and directly describes vortex dynamics. We introduce gauge fields in order to remove singularities from the Landau-Ginzburg order parameter of the superfluid, so that two kinds of gauge symmetries appear, making the continuity equation and conservation of the total vorticity manifest. The topological term gives rise to the Berry phase term in the vortex mechanical actions.Comment: LATEX, 9 page

Phase separation and vortex states in binary mixture of Bose-Einstein condensates in the trapping potentials with displaced centers

The system of two simultaneously trapped codensates consisting of $^{87}Rb$ atoms in two different hyperfine states is investigated theoretically in the case when the minima of the trapping potentials are displaced with respect to each other. It is shown that the small shift of the minima of the trapping potentials leads to the considerable displacement of the centers of mass of the condensates, in agreement with the experiment. It is also shown that the critical angular velocities of the vortex states of the system drastically depend on the shift and the relative number of particles in the condensates, and there is a possibility to exchange the vortex states between condensates by shifting the centers of the trapping potentials.Comment: 4 pages, 2 figure

Demixing in mesoscopic boson-fermion clouds inside cylindrical harmonic traps: quantum phase diagram and role of temperature

We use a semiclassical three-fluid thermodynamic model to evaluate the phenomena of spatial demixing in mesoscopic clouds of fermionic and bosonic atoms at high dilution under harmonic confinement, assuming repulsive boson-boson and boson-fermion interactions and including account of a bosonic thermal cloud at finite temperature T. The finite system size allows three different regimes for the equilibrium density profiles at T=0: a fully mixed state, a partially mixed state in which the overlap between the boson and fermion clouds is decreasing, and a fully demixed state where the two clouds have zero overlap. We propose simple analytical rules for the two cross-overs between the three regimes as functions of the physical system parameters and support these rules by extensive numerical calculations. A universal ``phase diagram'' expressed in terms of simple scaling parameters is shown to be valid for the transition to the regime of full demixing, inside which we identify several exotic configurations for the two phase-separated clouds in addition to simple ones consisting of a core of bosons enveloped by fermions and "vice versa". With increasing temperature the main role of the growing thermal cloud of bosons is to transform some exotic configurations into more symmetric ones, until demixing is ultimately lost. For very high values of boson-fermion repulsive coupling we also report demixing between the fermions and the thermally excited bosons.Comment: 11 pages, 8 figure