51,325 research outputs found
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Rethinking the Origins of Transnational Humanitarian Organizations: The Curious Case of the International Shipwreck Society
By exploring the evolution of the International Shipwreck Society (ISS) â a previously neglected transnational humanitarian organization encompassing branches in every continent by the late 1830s â this article sheds new light on three key aspects of the development of global humanitarianism. First, through revealing how a secular humanitarian association with a global organizational structure was developed in the 1830s, the article challenges conventional assumptions with respect to when internationally organized humanitarian action became possible. Second, through exploring the influence of Chinese precedents in the ISS, the article reveals the importance in the development of transnational humanitarianism of previously neglected Eastern origins. Third, through evaluating the role of individuals in the evolution of the ISS, the article provides a more balanced perspective on the role of individual leadership in early transnational humanitarian organizations than has traditionally been put forward. In each of these aspects, the article provides a new perspective on the origins of global networks
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The Rise and Fall of Transnational Civil Society: The Evolution of International Non-Governmental Organisations since 1839
Skyrme-force time-dependent Hartree-Fock calculations with axial symmetry
We discuss axially symmetric time-dependent Hartree-Fock calculations using a finite-range modification of the Skyrme energy functional. The finite-difference forms of the coordinate-space time-dependent Hartree-Fock equations, the method of time evolution, and other numerical aspects are presented. Detailed results for (^84)Kr-induced deep-inelastic collisions with (^208)Pb at E_(lab) = 494 MeV and with (^209)Bi at E_(lab) = 600 MeV and 714 MeV are compared with experiment.
[NUCLEAR REACTIONS (^84)Kr + (^208)Pb at E_lab = 494 MeV and (^84)Kr + (^209)Bi at E_1ab=600 and 714 MeV, in the time-dependent Hartree-Fock approximation. Strongy
damped collisions. Details of Skyrme force calculations with axial symmetry.
Predicting the outer membrane proteome of Pasteurella multocida based on consensus prediction enhanced by results integration and manual confirmation
Background
Outer membrane proteins (OMPs) of Pasteurella multocida have various functions related to virulence and pathogenesis and represent important targets for vaccine development. Various bioinformatic algorithms can predict outer membrane localization and discriminate OMPs by structure or function. The designation of a confident prediction framework by integrating different predictors followed by consensus prediction, results integration and manual confirmation will improve the prediction of the outer membrane proteome.
Results
In the present study, we used 10 different predictors classified into three groups (subcellular localization, transmembrane β-barrel protein and lipoprotein predictors) to identify putative OMPs from two available P. multocida genomes: those of avian strain Pm70 and porcine non-toxigenic strain 3480. Predicted proteins in each group were filtered by optimized criteria for consensus prediction: at least two positive predictions for the subcellular localization predictors, three for the transmembrane β-barrel protein predictors and one for the lipoprotein predictors. The consensus predicted proteins were integrated from each group into a single list of proteins. We further incorporated a manual confirmation step including a public database search against PubMed and sequence analyses, e.g. sequence and structural homology, conserved motifs/domains, functional prediction, and protein-protein interactions to enhance the confidence of prediction. As a result, we were able to confidently predict 98 putative OMPs from the avian strain genome and 107 OMPs from the porcine strain genome with 83% overlap between the two genomes.
Conclusions
The bioinformatic framework developed in this study has increased the number of putative OMPs identified in P. multocida and allowed these OMPs to be identified with a higher degree of confidence. Our approach can be applied to investigate the outer membrane proteomes of other Gram-negative bacteria
Work minimization accounts for footfall phasing in slow quadrupedal gaits
Quadrupeds, like most bipeds, tend to walk with an even left/right footfall timing. However, the phasing between hind and forelimbs shows considerable variation. Here, we account for this variation by modeling and explaining the influence of hind-fore limb phasing on mechanical work requirements. These mechanics account for the different strategies used by: (1) slow animals (a group including crocodile, tortoise, hippopotamus and some babies); (2) normal medium to large mammals; and (3) (with an appropriate minus sign) sloths undertaking suspended locomotion across a range of speeds. While the unusual hind-fore phasing of primates does not match global work minimizing predictions, it does approach an only slightly more costly local minimum. Phases predicted to be particularly costly have not been reported in nature
New Cosmological Structures on Medium Angular Scales Detected with the Tenerife Experiments
We present observations at 10 and 15 GHz taken with the Tenerife experiments
in a band of the sky at Dec.=+35 degrees. These experiments are sensitive to
multipoles in the range l=10-30. The sensitivity per beam is 56 and 20 microK
for the 10 and the 15 GHz data, respectively. After subtraction of the
prediction of known radio-sources, the analysis of the data at 15 GHz at high
Galactic latitude shows the presence of a signal with amplitude Delta Trms ~ 32
microK. In the case of a Harrison-Zeldovich spectrum for the primordial
fluctuations, a likelihood analysis shows that this signal corresponds to a
quadrupole amplitude Q_rms-ps=20.1+7.1-5.4 microK, in agreement with our
previous results at Dec.+=40 degrees and with the results of the COBE DMR.
There is clear evidence for the presence of individual features in the RA range
190 degrees to 250 degrees with a peak to peak amplitude of ~110 microK. A
preliminary comparison between our results and COBE DMR predictions for the
Tenerife experiments clearly indicates the presence of individual features
common to both. The constancy in amplitude over such a large range in frequency
(10-90 GHz) is strongly indicative of an intrinsic cosmological origin for
these structures.Comment: ApJ Letters accepted, 13 pages Latex (uses AASTEX) and 4 encapsulated
postscript figures
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The Transformation of International NGOs and Their Impact on Development Aid
International non-governmental organisations (INGOs) are among the key actors in the transformation of development as a global public policy issue in the post-Cold War era. This chapter explores how in the past two decades INGOs concerned with development have transformed their structures and practices as well as development discourse. The author shows how development INGOs have globalised, in terms of both the formation of international confederations and the collaboration of multiple INGOs in global coalitions.
A key development has been the erosion of the apparent NorthâSouth divide among development INGOs, with INGOs that originated in donor countries reforming their structures to give a greater voice to their affiliates in recipient countries, and organisations that originated in developing countries forming affiliates in developed countries. The reorientation of INGO advocacy from states toward intergovernmental and corporate actors is also explored, as is the creation of new forms of partnerships with both governmental and private actors. The chapter addresses how development INGOs have attempted to respond to critiques of their accountability and legitimacy through reforms such as the International NGO Charter on Accountability, while the conclusion explores the limitations of the transformations of development INGOs, and the challenges that these new configurations pose
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Internationalism in a Divided World: The Experience of the International Federation of League of Nations Societies, 1919â1939
Despite the challenges of the geopolitical divisions of the interwar years, the International Federation of League of Nations Societies (IFLNS) brought together associations claiming to promote the ideals of the League of Nations in forty countries. It pioneered techniques for the lobbying of intergovernmental organizations that were so extensive that some considered it a âthird chamberâ of the League of Nations, and in areas such as its minorities work the Federationâs independent policy initiatives may be considered to be precursors to present-day âpolitics beyond the state.â Based largely on hitherto neglected publications and archives of the IFLNS, this is the first article to evaluate specifically the work of a body that at the time was often considered to be the leading international nongovernmental organization for the promotion of peace between the world wars. The article introduces the evolution of the IFLNS and explores its national and international work in turn
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