3,743 research outputs found
Heart failure nursing in Australia: Challenges, strengths, and opportunities
Australia has a land mass similar to the United States of America, supporting
a population of just over 20 million, which is distributed predominantly
across the coastal perimeter. The Australian society is rich in cultural diversity fostered by decades of migration. Both these factors present challenges for health care. First, because resources are scare in rural and remote regions, health outcomes are poorer in these regions, especially among indigenous populations. Second, the cultural diversity of Australians is a challenge to providing evidence-based treatment recommendations. In Australia, in parallel with international trends, there is a strong association between
socioeconomic status, chronic conditions, and health outcomes
The generalized Fenyes-Nelson model for free scalar field theory
The generalized Fenyes--Nelson model of quantum mechanics is applied to the
free scalar field. The resulting Markov field is equivalent to the Euclidean
Markov field with the times scaled by a common factor which depends on the
diffusion parameter. This result is consistent between Guerra's earlier work on
stochastic quantization of scalar fields. It suggests a deep connection between
Euclidean field theory and the stochastic interpretation of quantum mechanics.
The question of Lorentz covariance is also discussed.Comment: 6 page
Photofluid Instabilities of Hot Stellar Envelopes
Beginning from a relatively simple set of dynamical equations for a fluid
permeated by a radiative field strong enough to produce significant forces, we
find the structure of plane-parallel equilibria and study their stability to
small acoustic disturbances. In doing this, we neglect viscous effects and
complications of nongreyness. We find that acoutic instabilities occur over a
wide range of conditions below the Eddington limit. This result is in line with
findings reported twenty years ago but it contradicts some more recent reports
of the absence of instabilities. We briefly attempt to identify the causes of
the discrepancies and then close with a discussion of the possible
astrophysical interest of such instabilities.Comment: 10 pages, LaTeX, 5 postscript figures, to be published in Physics
Report
Differential coupling of G protein alpha subunits to seven-helix receptors expressed in Xenopus oocytes
Xenopus oocytes were used to examine the coupling of the serotonin 1c (5HT1c) and thyrotropin-releasing hormone (TRH) receptors to both endogenous and heterologously expressed G protein alpha subunits. Expression of either G protein-coupled receptor resulted in agonist- induced, Ca(2+)-activated Cl- currents that were measured using a two- electrode voltage clamp. 5HT-induced Cl- currents were reduced 80% by incubating the injected oocytes with pertussis toxin (PTX) and inhibited 50-65% by injection of antisense oligonucleotides to the PTX- sensitive Go alpha subunit. TRH-induced Cl- currents were reduced only 20% by PTX treatment but were inhibited 60% by injection of antisense oligonucleotides to the PTX-insensitive Gq alpha subunit. Injection of antisense oligonucleotides to a novel Xenopus phospholipase C-beta inhibited the 5HT1c (and Go)-induced Cl- current with little effect on the TRH (and Gq)-induced current. These results suggest that receptor- activated Go and Gq interact with different effectors, most likely different isoforms of phospholipase C-beta. Co-expression of each receptor with seven different mammalian G protein alpha subunit cRNAs (Goa, Gob, Gq, G11, Gs, Golf, and Gt) was also examined. Co-expression of either receptor with the first four of these G alpha subunits resulted in a maximum 4-6-fold increase in Cl- currents; the increase depended on the amount of G alpha subunit cRNA injected. This increase was blocked by PTX for G alpha oa and G alpha ob co-expression but not for G alpha q or G alpha 11 co-expression. Co-expression of either receptor with Gs, Golf, or Gt had no effect on Ca(2+)-activated Cl- currents; furthermore, co-expression with Gs or Golf also failed to reveal 5HT- or TRH-induced changes in adenylyl cyclase as assessed by activation of the cystic fibrosis transmembrane conductance regulator Cl- channel. These results indicate that in oocytes, the 5HT1c and TRH receptors do the following: 1) preferentially couple to PTX-sensitive (Go) and PTX-insensitive (Gq) G proteins and that these G proteins act on different effectors, 2) couple within the same cell type to several different heterologously expressed G protein alpha subunits to activate the oocyte's endogenous Cl- current, and 3) fail to couple to G protein alpha subunits that activate cAMP or phosphodiesterase
Limited effectiveness of high-dose liposomal amphotericin B (AmBisome) for treatment of visceral leishmaniasis in an Ethiopian population with high HIV prevalence.
Due to unacceptably high mortality with pentavalent antimonials, Médecins Sans Frontières in 2006 began using liposomal amphotericin B (AmBisome) for visceral leishmaniasis (VL) patients in Ethiopia who were severely ill or positive for human immunodeficiency virus (HIV)
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