Descriptive statistics for raw hippocampal, intracranial and total brain tissue volumes, grouped by genotype.

<p>Note. All volumes are in mm³, estimated marginal means adjusted for age and gender. ICV-corrected = additionally adjusted for intracranial volume, TBV-corrected = additionally adjusted for total brain tissue volume.</p

Translocase of outer membrane 40 (<i>TOMM40</i>) ‘<i>523</i>’ poly-T repeat genotype and hippocampal volumes.

<p>Note. Age at time of testing and gender statistically controlled. ICV-corrected = intracranial volume included as a covariate, TBV-corrected = total brain tissue volume included as a covariate.</p

Basic demographic and clinical data for the current sample.

<p>Note. SD = standard deviation, MMSE = Mini-Mental State Exam (maximum score of 30). These data are based on the sample of participants with successfully segmented hippocampal volumes, once those participants with reported dementia, or with MMSE scores ≤24 (or missing) around the time of MRI, were removed. </p

Summary of previous large cross-sectional studies (i.e. N > 135) examining <i>APOE</i> ε4 genotype and hippocampal volumes in non-demented, community dwelling older adults.

<p>Note. The age mean and standard deviation data provided above for Lemaitre et al., Den Heijer et al. and Hostage et al. are weighted estimates; see those reports for exact age data</p

Apolipoprotein-e (<i>APOE</i>) ε genotype and hippocampal volumes.

<p>Note. Age at time of testing and gender statistically controlled. ICV-corrected = intracranial volume included as a covariate, TBV-corrected = total brain tissue volume included as a covariate.</p